Results 41 to 50 of about 307,460 (239)

EDNRA Forms a Positive Feedback Loop with the Hippo/YAP Axis to Drive Triple‐Negative Breast Cancer Progression

Advanced Science, EarlyView.
Endothelin receptor type A (EDNRA) and the Hippo/YAP pathway form a self‐reinforcing loop that sustains triple‐negative breast cancer. EDNRA activates YAP through Gαq/11–Rho/ROCK–LATS signaling, while YAP/TEAD4 reciprocally drives EDNRA transcription.
Zehao Hong, Boyang Li, Jiahui Xu, Ruonan Lin, Jinghao Pan, Chenlu Fang, Boxiang Zhang, Lucy Yue Lau, Richard J. Aldridge, Elizabeth A. Whitmore, Yi Chen   +10 more
wiley   +1 more source

Availability, prices and affordability of essential medicines in Haiti [PDF]

Journal of Global Health, 2013
Haiti is the poorest country in the Western Hemisphere and faces numerous challenges, including inadequate medication access for its residents. The objective of this study was to determine the availability, prices, and affordability of essential ...
Harinder Singh Chahal , Nazaire St. Fort , Lisa Bero   +2 more
doaj  

Chromatin Packing Domain Engineering Through the Manipulation of Nuclear Cationic States

Advanced Science, EarlyView.
Manipulation of intranuclear divalent cation concentrations rapidly and reversibly remodels chromatin packing domains in living cells. Magnesium depletion disrupts domain compaction, heterochromatin organization, and transcriptional regulation, whereas magnesium loading promotes more compact and stable domains.
Cody L. Dunton, Carrillo Paola Gonzalez, Luay Almassalha, Wing Shun Li, Ruyi Gong, Nicolas Acosta, I Chae Ye, Jane Frederick, Christopher Hogg, Saira John, J. A. Gareth Williams, Rikkert J. Nap, Igal Szleifer, Vadim Backman   +13 more
wiley   +1 more source

Drop‐Location‐Insensitive Droplet‐Based Electricity Generator Using Polydimethylsiloxane Slippery Covalently Attached Liquid Coatings

Advanced Science, EarlyView.
Drop‐location sensitivity remains a key barrier to practical droplet‐based electricity generators (DEGs). Here, a polydimethylsiloxane slippery covalently attached liquid (PDMS‐SCAL)‐coated interface promotes droplet sliding instead of splitting or bouncing, allowing stable electricity generation from randomly falling raindrops. The resulting PDMS‐SCAL‐
Jung Bin Yang, Donghyeon Yoo, Hideaki Teshima, Donghan Lee, Dongwhi Choi, Dong Rip Kim, Nenad Miljkovic   +6 more
wiley   +1 more source

Giant Magnetic Purcell Effect Induced by High‐Order Mie Resonances

Advanced Science, EarlyView.
High‐order Mie resonances in dielectric spheres selectively amplify magnetic dipole emission from Eu3+ emitters, producing a giant magnetic Purcell effect. Localized emitters can efficiently access high‐order resonant modes, and the low‐loss TiO2 platform enables direct far‐field observation of the enhanced emission.
Haonan Shi, Ningning Song, Anjun Huang, Zhengwen Yang, Jingbo Sun, Yongzheng Wen, Ji Zhou   +6 more
wiley   +1 more source

Initial Development Through Serial Pilot Studies of the Pickleball Power and Placement Test

J
There are no widely used standardized tests of pickleball skill. The purpose of this research was to develop a test to represent general paddle-stroke ability via evaluation of the serve.
Eric A. Martin, Steven B. Kim, James J. Annesi, George K. Beckham   +3 more
doaj   +1 more source

Micropaisagem: os circuitos da Cal em José Luís Peixoto

Forma Breve, 2008
Recusando em Cal a homogeneidade genológica como princípio aglutinador dos textos que compõem o volume, José Luís Peixoto converte a óbvia pertença destes textos ao espaço físico-simbólico da cal numa espécie de arquitexto de substituição ou de ...
Isabel Cristina Rodrigues
doaj   +1 more source

Protease‐Triggered Chromogenic Release From Peptide‐Modified Calcium Carbonate Microspheres Enables Colorimetric Detection of Porphyromonas gingivalis Activity

Advanced Science, EarlyView.
We report a chromogenic release‐based assay system with protease‐cleavage peptide‐modified calcium carbonate microspheres for colorimetric detection of Porphyromonas (P.) gingivalis activity. In response to Arg‐specific gingipain secreted by P. gingivalis, the supernatant becomes colored, enabling colorimetric analysis and providing the monitoring of ...
Yuki Hiruta, Zhicheng Jin, Mari Adachi, Lubna Amer, Natalia O. Tjokro, Diego F. Trujillo, Jan Potempa, Anthony J. O'Donoghue, Casey Chen, Jesse V. Jokerst   +9 more
wiley   +1 more source

Canonical Antibodies Adopt Distinct Binding Modes to Recognize Viral Glycan Shields

Advanced Science, EarlyView.
Canonical Y‐shaped antibodies recognize viral glycan shields through adaptive Fab assembly states shaped by glycan organization and somatic hypermutation. Structural analyses ofbroadly neutralizing antibodies VRC35 and VRC36 across glycoproteins of HIV‐1, influenza, SARS‐CoV‐2, and Lassa viruses reveal distinct Fab assembly states, spanning monovalent,
Jiaxuan Cheng, Evan M. Cale, Amirabbas Maghsoudi, Matthew S. Sutton, Nancy S. Longo, Rebecca A. Gillespie, Lingshu Wang, Ivan Kosik, Sue Chong, Atsuhiro Yasuhara, Tatsiana Bylund, Arne Schön, Prabhanshu Tripathi, Yaroslav Tsybovsky, Haotian Lei, Nicholas C. Morano, Allison B. Lupatkin, Abraham J. Morton, Zabrina C. Lang, Jordan E. Becker, Isabella R. Frascilla, Myungjin Lee, Ning Li, Cuiping Liu, Ryan S. Roark, Chen‐Hsiang Shen, I‐Ting Teng, David J. Van Wazer, Danyi Wang, Lingyuan Wu, Goran Ahlsen, Mike Castro, Haijuan Du, Michael J. Ernandes, Tiansheng Li, Bob C. Lin, Mark K. Louder, Krisha McKee, Jonah S. Merriam, Sijy O'Dell, Li Ou, Sergei Pletnev, David Prikryl, Qi Qiu, Sarah Rubin, Mallika Sastry, Stephen D. Schmidt, Asif Shajahan, Andrea R. Shiakolas, Sanjay Srivatsan, Baoshan Zhang, Qiong Zhou, Mark Connors, Jason G. Gall, Yicheng Guo, Rick K. Huang, Yaoxing Huang, Richard A. Koup, Q. Paula Lei, John R. Mascola, Reda Rawi, Leonid Serebryannyy, Lawrence Shapiro, Zizhang Sheng, David D. Ho, Patrick C. Wilson, Jonathan W. Yewdell, Theodore C. Pierson, Masaru Kanekiyo, Nicole A. Doria‐Rose, Peter D. Kwong, Tongqing Zhou   +71 more
wiley   +1 more source

Comportamiento de una pista experimental de pavimento flexible con base estabilizada con cal Behavior of an experimental track of flexible pavement with lime stabilized base

Revista Ingenierías Universidad de Medellín, 2010
En este trabajo se presentan resultados de una investigación realizada para determinar las propiedades de deformabilidad de bases estabilizadas con cal a partir de ensayos de campo no destructivos. Se realizaron ensayos de placa estática y viga Benkelman
César Augusto Hidalgo Montoya, Carlos Arturo Pandales, Boris Andrés Pedroza Valdés, Mario Alberto Rodríguez Moreno   +3 more
doaj