Results 41 to 50 of about 162,116 (246)

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

Improvement of Coral Sand With MICP Using Various Calcium Sources in Sea Water Environment

open access: yesFrontiers in Physics, 2022
Microbial-induced calcium carbonate precipitation (MICP) is a promising technique for strengthening soil. The influences calcium sources (calcium chloride, calcium acetate, and calcium nitrate) and seawater/freshwater environment on the improvement of ...
Jie Peng   +4 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

open access: yesMolecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang   +9 more
wiley   +1 more source

A Study of Hot Rolling Oil with Calcium Carbonate for Stainless Steel Process

open access: yesTribology Online, 2010
Dispersion-type lubricants formulated with calcium carbonate were experimentally studied to achieve improved hot-rolling characteristics of stainless steel.
Naoshi Shimotomai   +2 more
doaj   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

open access: yesFEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho   +4 more
wiley   +1 more source

Modulating Redox Mechanism in Metal Chalcogenides by Precisely Controlling Phase Transition to Achieve Ultrafast and Ultra‐Stable Sodium‐Ion Batteries

open access: yesCarbon Energy
Metal chalcogenides represent promising anodes for sodium‐ion batteries due to their high theoretical capacities and low material costs. However, their practical applications are hampered by inherently sluggish ion diffusion kinetics and severe volume ...
Yishun Xie   +13 more
doaj   +1 more source

Discrete Element Study on Mechanical Properties of MICP-Treated Sand under Triaxial Compression

open access: yesJournal of Marine Science and Engineering
Microbial-induced calcium carbonate precipitation (MICP) has attracted much attention as a promising technology for soil improvement in the infrastructures of marine engineering.
Liquan Xie   +5 more
doaj   +1 more source

Dissolution Rates of Calcium Boluses and Their Effects on Serum Calcium in Dairy Cattle [Corrigendum]

open access: yesVeterinary Medicine: Research and Reports, 2021
Verhoef W, Zuidhof S, Ralston B, Ross JA, Olson M. Vet Med (Auckl). 2021;12:23– 32   Table 1 Composition of the Commercially Available Boluses Used in This Study   Page 24, Materials and Methods, In vivo Dissolution Rates of ...
Verhoef W   +4 more
doaj  

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

open access: yesFEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young   +7 more
wiley   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

open access: yesFEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento   +6 more
wiley   +1 more source

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