Results 91 to 100 of about 287,864 (261)

High-Risk Coronary Plaques and Carotid Duplex Findings in Asymptomatic Patients Undergoing Primary Prevention Assessment

Journal of Cardiovascular Development and Disease
Subclinical coronary atherosclerosis is common but its biological aggressiveness and interplay with extracoronary disease in asymptomatic individuals remain unclear.
Lucio Addeo, Pasquale Guarini, Carlo Tedeschi, Antonio Rapacciuolo, Salvatore Severino, Mario De Michele, Milena Sidiropulos, Mattia Silvestre, Carlo Liguori, Luigi Cocchiara, Stefano Nardi, Luigi Argenziano, Vittoria Marino, Pasquale Campana, Roberto Franco Enrico Pedretti, Maurizio Bussotti, Laura Adelaide Dalla Vecchia   +16 more
doaj   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Preliminary Exploration of Non-gated High-pitch Chest CT Combined with Artificial Intelligence in Assessing Coronary Artery Calcium Score

CT Lilun yu yingyong yanjiu
Objective: To investigate the feasibility of using non-gated high-pitch chest computed tomography (CT) combined with artificial intelligence (AI) technology to measure the coronary artery calcium score.
Dandan LIU, Wei LI, Yongxian ZHANG, Bo ZHAO, Ying CUI, Tianliang KANG, Zixuan MA, Yuhang LIU, Yantao NIU   +8 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Gender and age effects on coronary calcium index in patients with suspected CHD

Наука и инновации в медицине
Aim – to assess the influence of sex and age on the coronary artery calcium (CAC) score in patients with suspected coronary heart disease (CHD). Material and methods. A prospective, observational, single-center study was conducted.
P. R. Shatskaya, Olesya A. Rubanenko, Irina Zolotovskaya, Elena V. Adonina, Dmitry V. Duplyakov   +4 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Coronary Artery Calcium Scores II [PDF]

Mayo Clinic Proceedings, 2021
openaire   +2 more sources

Exploring the Complex Interplay: Fatty Liver Severity, Epicardial Fat Volume, and Coronary Artery Calcification [PDF]

پزشکی بالینی ابن سینا
Background and Objective: Cardiovascular diseases and nonalcoholic fatty liver disease are the most common non-communicable diseases in most developed countries, and due to lifestyle changes, their incidence is increasing day by day.
Seyed Kamaledin Hadei, Eghbal Abarvazn
doaj  

Computed Tomography in the Evaluation and Identification of Features of Coronary Atherosclerosis Between European and Asian Populations in Kazakhstan

Medicina
Background and Objectives: This study aimed to compare coronary plaque characteristics between Asian and European populations undergoing coronary CT angiography and to examine associations between cardiovascular risk factors and coronary artery ...
Tairkhan Dautov, Elmira Yelshibayeva, Makhabbat Tynybekova, Bakyt Duisenbayeva, Lazzat Bastarbekova, Tokhirzhan Tashpulatov, Kuralay Sharipova, Shokhrukh Akhnazarov, Daniyar Kudabayev, Kemelya Nigmetova, Nurly Kapashova   +10 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source