Results 121 to 130 of about 1,601,048 (308)
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Effect of RH Non-adding Ca Treatment on D and Ds Inclusion of SCM435 Cold Heading Steel
Teshugang, 2020 The production flow sheet of SCM435 steel is 80 t BOF-LF-RH-280 mm x 325 mm bloom casting. LF end refining slag composition is (/% ：) 45 〜55 CaO, 10 〜15SiO220 〜30 Al2O3∑(FeO + MnO) ≤ 1 % .
李永超, 吕皓杰, 李龙
doaj
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
A Kinetic Model for the Modification of Al2O3 Inclusions during Calcium Treatment in High-Carbon Hard Wire Steel. [PDF]
Materials (Basel), 2021 Xi Z, Li C, Wang L.
europepmc +1 more source
Improving the quality of various types of recycled aggregates by biodesposition [PDF]
, 2017 Demand for construction materials has been rising in recent decades in many countries around the world, placing a heavy burden on the environment in terms of both the natural resources consumed and the enormous flow of waste generated. In order to obtain
Boon, Nico +7 more
core +1 more source
Molecular Oncology, EarlyView.Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad +35 more
wiley +1 more source
Krónikus kalcium antagonista kezelés hatása a szívizomra = The effects of chronic calcium channel blocker treatment on heart [PDF]
, 2012 A project célja az volt, hogy megvizsgáljuk, milyen hatással van a kalcium antagonista krónikus adagolása a szívizom L-típusú kalcium-csatornáinak molekuláris biológiai és elektorfiziológiai sajátságaira.
Bányász, Tamás +7 more
core
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Effects of Calcium Nutrition on Soybean Growth and Symbiotic Nitrogen Fixation
AgronomyCalcium is essential for legume symbiotic nitrogen fixation, acting as both a nutrient and a signal. Yet, how varying calcium levels—from deficiency to toxicity—affect the soybean ‘root-nodule-stem’ balance has not been fully elucidated.
Sutong Zhao +5 more
doaj +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source