Results 91 to 100 of about 1,445,100 (299)

ROUTE SIMULATION TRANSPORTS POLYGONAL SECTION CANAL WITH COMPLEX PROGRAM

open access: yesВестник Дагестанского государственного технического университета: Технические науки, 2016
The paper considers the problem of modeling the optimal route of the canal conveying polygonal cross-sectional shape, which extends into the recess without artificially mount.
G. A. Alibekov
doaj   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

open access: yesFEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman   +2 more
wiley   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

Comparison of Calculation Methods for Local Scour in Bridge Pier Foundation of Piles-Cushion Cap

open access: yesZhongwai Gonglu
In order to analyze the calculation methods for local scour in bridge pier foundation of piles-cushion cap, this paper listed the six common Chinese and foreign calculation methods, described their calculation process and selection of calculation ...
LIU Hui, JIANG Yanhua, YAN Jiechao
doaj   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Development of Automatic Calculation Program for Passenger Flow Assignment in Urban Rail Transit Network Based on VISUM

open access: yesChengshi guidao jiaotong yanjiu
[Objective] In view of the much repetitive work in the calculation process of passenger flow assignment in urban rail transit network, an automatic calculation program is developed on the basis of the research on the passenger flow assignment process ...
Tianzhe ZANG, Baonan GU
doaj   +1 more source

The Variational Homotopy Perturbation Method for Solving ((n×n)+1) Dimensional Burgers’ Equations

open access: yesJournal of Applied Mathematics, 2016
The variational homotopy perturbation method VHPM is used for solving n-dimensional Burgers’ system. Some examples are examined to validate that the method reduced the calculation size, treating the difficulty of nonlinear term and the accuracy.
F. A. Hendi   +2 more
doaj   +1 more source

PICALM::MLLT10 translocated leukemia

open access: yesFEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen   +7 more
wiley   +1 more source

Transient heating of moving objects

open access: yesElectrical engineering & Electromechanics, 2014
A mathematical model of transient and quasistatic heating of moving objects by various heat sources is considered. The mathematical formulation of the problem is described, examples of thermal calculation given.
E.I. Baida
doaj  

Home - About - Disclaimer - Privacy