Results 141 to 150 of about 214,662 (263)

Revisiting symbolic addition: a step-by-step introduction to manual direct methods. [PDF]

Acta Crystallogr E Crystallogr Commun
Weirich TE.
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

A quantitative framework for subsurface uncertainty assessment using multidisciplinary geoscientific data. [PDF]

MethodsX
Chavanidis K, Abu-Mahfouz IS.
europepmc   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

A practical guide to RRKM theory, its simplified multi-well version AWATAR and master equation modelling of radiative processes.

Phys Chem Chem Phys
Salzburger M, Reimann M, Hartmann JC, Ončák M, Beyer MK.   +4 more
europepmc   +1 more source

<i>GenL</i>: an extensible fitting program for Laue oscillations and whole-pattern fitting. [PDF]

J Appl Crystallogr
Ravensburg AL, Bylin J, Kapaklis V, Pálsson GK.   +3 more
europepmc   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

A Homology-Based Application to Diagnose Colorectal Adenoma and Early-Stage Cancer. [PDF]

Pathol Int
Yokoyama Y, Kanayama K, Matsuda M, Hatori N, Asano T, Morii E, Yamamoto H, Nakane K.   +7 more
europepmc   +1 more source

Examples of Calculation of the flow in branch pipes

Transactions of the Japan Society of Mechanical Engineers, 1945
openaire   +2 more sources