Results 141 to 150 of about 147,549 (388)
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Dual energy CT for evaluation of patients with urinary stones
Zdravniški Vestnik, 2014 Size, location and estimation of composition of urinary stone dictate treatment decisions. Non-contrast low dose CT has replaced iv-urography for evaluation of size and position of stone.
Marija Šantl - Letonja, Tine Hajdinjak
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South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1974 The chemical composition of 256 urinary calculi on the Witwatersrand has been determined in 3 population groups. 'Calcium stones' comprised 53,1% of the total and most of the remainder were triple phosphate. The distribution of these stones in the different population groups was similar. Urinary calculi are rare in the Bantu.S. Afr. Med.
Pantanowitz, D +3 more
openaire +2 more sources
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
A theory of effects and resources: adjunction models and polarised calculi
ACM-SIGACT Symposium on Principles of Programming Languages, 2016 P. Curien +2 more
semanticscholar +1 more source
Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source
A Novel Technique for Treatment of Distal Ureteral Calculi: Early Results
Urology Journal, 2013 No ...
Turhan Caskurlu +2 more
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