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A freely mobile calcified or noncalcified nodule in the pleural cavity, known as thoracolithiasis, is quite rare. There are several reports of CT findings of thoracolithiasis, but there is no report of thoracolithiasis mistakenly considered as a pleural
Yoon Ki Cha+3 more
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The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp+5 more
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UDP‐glucuronic acid 4‐epimerase (UGAepi) catalyzes NAD+‐dependent interconversion of UDP‐glucuronic acid (UDP‐GlcA) and UDP‐galacturonic acid (UDP‐GalA) via C4‐oxidation, 4‐keto‐intermediate rotation, and C4‐reduction. Here, Borg et al. examined the role of the substrate's carboxylate group in the enzymic mechanism by analyzing NADH‐dependent reduction
Annika J. E. Borg+2 more
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A middle aged women with bilateral staghorn complete calculi
A 50-year-old woman presented with a 2-years history of chronic flanc and hematuria. Plain abdominal radiography was performed showing bilateral complete staghorn calculi.
Jihad El Anzaoui, Driss Touiti
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Pathogenesis and prevention of residual gall bladder: Report of three cases and review of literature
Cholecystectomy is a common surgery performed for uncomplicated symptomatic gall stones as a definitive procedure. For complicated cases, partial or modified subtotal cholecystectomy has been described as an easy, safe, and definitive option.
Usha Dalal+4 more
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Several case-control studies have been performed in different populations to uncover the association between interleukin-1 beta gene, interleukin-1 receptor antagonist gene polymorphisms and urolithiasis.
Jiaxuan Qin, Jinchun Xing, Zonglong Cai
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Glutaredoxin (Grx) 3 proteins contain a thioredoxin domain and one to three class II Grx domains. These proteins play a crucial role in iron homeostasis in eukaryotic cells. In human Grx3, at least one of the two Grx domains, together with the thioredoxin domain, is essential for its function in iron metabolism.
Laura Magdalena Jordt+4 more
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Dimeric pyruvate formate‐lyase cleaves pyruvate using a radical‐based mechanism. G734 serves as a radical storage location, and the radical is transferred to the catalytic C419 residue. Mutation of the C418‐C419 pair causes loss of enzyme activity, but does not impede radical introduction onto G734. Therefore, cis‐ but not trans‐radical transfer occurs
Michelle Kammel+2 more
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To explore the impact of the overexpression of the multidrug‐transporter P‐glycoprotein (ABCB1) on membrane fluidity, we compared the transversal gradient of mobility and microviscosity in plasma membranes of drug‐sensitive Chinese hamster ovary cells (AuxB1) and their multidrug‐resistant derivatives (B30) using the fluorescent n‐(9‐anthroyloxy) fatty ...
Roger Busche+2 more
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A vesicocutaneous fistula secondary to bladder calculi in a patient with spina bifida
We present a rare case of a vesicocutaneous fistula secondary to two large bladder calculi in a patient with spina bifida. A 62 year old lady presented with swelling of her right thigh and a calcified mass protruding through the subcutaneous tissues of ...
Jonathan D Horsnell, Richard B Kinder
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