Results 91 to 100 of about 765,231 (326)

Structural insights into lacto‐N‐biose I recognition by a family 32 carbohydrate‐binding module from Bifidobacterium bifidum

FEBS Letters, EarlyView.
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang, Naoki Sunagawa, Toma Kashima, Kiyohiko Igarashi, Akimasa Miyanaga, Shinya Fushinobu   +5 more
wiley   +1 more source

Two-scale mathematics and fractional calculus for thermodynamics

Thermal Science, 2019
A three dimensional problem can be approximated by either a two-dimensional or one-dimensional case, but some information will be lost. To reveal the lost information due to the lower dimensional approach, two-scale mathematics is needed.
Ji-Huan He, Feiyu Ji
semanticscholar   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Completeness of Flat Coalgebraic Fixpoint Logics

, 2010
Modal fixpoint logics traditionally play a central role in computer science, in particular in artificial intelligence and concurrency. The mu-calculus and its relatives are among the most expressive logics of this type.
Gastin, P., Laroussinie, F., Schröder, L., Venema, Y.   +3 more
core   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Software Support for the Higher Mathematics Course at the Technical University

Mìkrosistemi, Elektronìka ta Akustika
The paper addresses the challenges of training modern engineers in mathematical disciplines. It emphasizes the need for graduates to possess theoretical knowledge and be capable of using modern software solutions for efficient mathematical calculations ...
Oleksii Viktorovych Bogdanov, Yurii Pavlovych Butsenko, Olena Ivanivna Balina, Iryna Srhiivna Bezklubenko   +3 more
doaj   +1 more source

Metabolic investigation of patients with staghorn calculus: is it necessary?

International Brazilian Journal of Urology, 2009
Objective: To evaluate the prevalence of metabolic disorders in patients with staghorn calculi treated at the Regional Center of Lithiasis Metabolic Studies in central region of São Paulo State, Brazil.
Carmen R. P. Amaro, Jose Goldberg, Aparecido D. Agostinho, Patricia Damasio, Paulo R. Kawano, Oscar E. H. Fugita, Joao L. Amaro   +6 more
doaj   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Correctness of copy in calculi with letrec, case, constructors and por [PDF]

, 2007
This paper extends the internal frank report 28 as follows: It is shown that for a call-by-need lambda calculus LRCCP-Lambda extending the calculus LRCC-Lambda by por, i.e in a lambda-calculus with letrec, case, constructors, seq and por, copying can be ...
Schmidt-Schauß, Manfred
core