Results 171 to 180 of about 47,945 (344)

Auditory Hair Cell Mechanotransduction Channels Dynamically Shape the Mechanical Properties of Their Membrane Environment

Advanced Science, EarlyView.
This work shows, for the first time, that the stereocilia membrane in cochlear hair cells is dynamically regulated by the mechanotransduction channel to impact the membrane mechanical properties. This work provides direct evidence that the opening and closing associated with the MET channel is regulating the membrane viscosity suggesting that the MET ...
Shefin S. George, Anthony J. Ricci
wiley   +1 more source

Extracellular Vesicle‐Delivered tRF‐His‐GTG‐1 Reprograms Neutrophil Lipophagy and Triggers Inflammation in COVID‐19

Advanced Science, EarlyView.
This study identifies platelet‐derived extracellular vesicles as key immunometabolic regulators in COVID‐19. The delivery of tRF‐His‐GTG‐1 to neutrophils activates TLR8mTOR signaling, disrupts lipophagy, and amplifies NET‐mediated inflammation. Importantly, targeting this axis restores neutrophil homeostasis, offering a potential therapeutic strategy ...
Tsai‐Ling Liao, Po‐Yu Liu, Yi‐Ming Chen, Kuo‐Tung Tang, Hung‐Jen Liu, Der‐Yuan Chen   +5 more
wiley   +1 more source

DEL‐1 is an Endogenous Senolytic Protein that Inhibits Senescence‐Associated Bone Loss

Advanced Science, EarlyView.
Senescent bone marrow stromal cells accumulate in the aging bone microenvironment, promoting bone degeneration. DEL‐1, an endogenous secreted protein, acts as a natural senolytic that selectively eliminates these cells. By engaging a β3 integrin/CD73/adenosine/p38 MAPK/BCL‐2 pathway, DEL‐1 counters aging‐related bone loss, revealing promising ...
Jong‐Hyung Lim, Kridtapat Sirisereephap, Hui Wang, Giulia Trimaglio, Kyoung‐Jin Chung, Jonathan Korostoff, Tetsuhiro Kajikawa, Xiaofei Li, Meircurius D.C. Surboyo, Tomoki Maekawa, Triantafyllos Chavakis, George Hajishengallis   +11 more
wiley   +1 more source

Discovery of a Novel and Potent Kir4.1 Inhibitor as a Safe and Rapid‐Onset Antidepressant Agent in Mice

Advanced Science, EarlyView.
The preferred derivative JX3212 demonstrates strong inhibitory activity against Kir4.1 with favorable druggability and shows significant antidepressant efficacy in vivo. Abstract Major depressive disorder is a serious psychiatric disorder for which novel and fast‐acting antidepressants are required.
Sisi Wang, Xiaoyu Zhou, Mengdan Li, Chao Zhang, Haiyan Xu, Jingyi He, Li Zhan, Yueling Gu, Hao Gu, Tianyu Tu, Hanfang Liu, Taotao Lu, Yueming Zheng, Jian Li, Zhaobing Gao, Yixiang Xu   +15 more
wiley   +1 more source

Dental calculus removal [PDF]

British Dental Journal, 2009
openaire   +1 more source

Supplementary Tables 1-8 from Multi-omic detection of Mycobacterium leprae in archaeological human dental calculus

, 2020
Anna K. Fotakis, Sean Dexter Denham, Meaghan Mackie, Miren Iraeta-Orbegozo, Dorothea Mylopotamitaki, Shyam Gopalakrishnan, Thomas Sicheritz‐Pontén, Jesper V. Olsen, Enrico Cappellini, Guojie Zhang, Axel Christophersen, M. Thomas P. Gilbert, Åshild J. Vågene‬   +12 more
openalex   +1 more source

Functional diversity of microbial ecologies estimated from ancient human coprolites and dental calculus [PDF]

, 2020
David Jacobson, Tanvi P. Honap, Cara Monroe, Justin Lund, Brett A. Houk, Anna Novotny, Cynthia Robin, Elisabetta Marini, Cecil M. Lewis   +8 more
openalex   +1 more source

Single‐Field Evolution Rule Governs the Dynamics of Representational Drift in Mouse Hippocampal Dorsal CA1 Region

Advanced Science, EarlyView.
Long‐term hippocampal place‐code dynamics are investigated using calcium imaging across weeks of maze navigation. Analyses reveal a novelty‐irrelevant Single‐Field Evolution Rule (SFER), where active fields promote persistence and inactive fields decline.
Cong Chen, Shuyang Yao, Sihui Cheng, Jiayi Tian, Ang Li, Yusen Yan, Xiang Zhang, Yuanjing Liu, Yumeng Wang, Qichen Cao, Chenglin Miao   +10 more
wiley   +1 more source

Dental Calculus Deposition: Correlation With Salivary Statherin and Calcium Levels. [PDF]

Int J Dent
Hase P, Shah V, Gunjal S, Manjunatha BS, Pateel DGS.   +4 more
europepmc   +1 more source

A Case of Giant Dental Calculus [PDF]

TOSHIYUKI INOU, Keiichi Uchida, Tatsuo Takaya, Hiroyuki Kitamura, Yu Chi Hung, EMI OKI, Nina Wakimoto, Toshiaki Ara, Hiroshi Mori, Nanae Dewake, Nobuo Yoshinari   +10 more
openalex   +1 more source