Results 211 to 220 of about 773,041 (378)

Irisin‐Loaded Cerium‐Containing Mesoporous Bioactive Glass for Effective Immunomodulation and Odontogenesis of Dental Pulp Cells

open access: yesAdvanced Science, EarlyView.
The Irisin/Ce‐MBGNs delivery system can slowly release myokine Irisin for vital pulp therapy. Irisin/Ce‐MBGNs can enhance mitochondrial function and promote the differentiation of inflammatory macrophages toward M2‐Mφ, thereby regulating the immune response mechanism of inflamed dental pulp.
Mingxin Wang   +9 more
wiley   +1 more source

FLASH Irradiation Modulates Immune Responses and Accelerates Lung Recovery: A Single‐Cell Perspective

open access: yesAdvanced Science, EarlyView.
Single‐cell RNA sequencing reveals distinct immune responses to FLASH versus conventional dose rate irradiation in early radiation‐induced lung injury. FLASH irradiation reduces Ccrl2⁺ neutrophil infiltration, activates CD4⁺ CD40L⁺ Th cells, restrains pro‐inflammatory Mefv⁺ monocytes, and enhances epithelial repair via TGF‐β signaling, underscoring its
Hao Lu   +10 more
wiley   +1 more source

Monitoring the prevalence and predictors of dental diseases in dogs

open access: yesBulgarian Journal of Veterinary Medicine
The increase in the share of dogs with dental pathology against the background of the appearance of new probable risk factors (in particular, the introduction of new diets in feeding), determine the rele-vance of regular monitoring of the spread and ...
D. D. Bilyi, U. I. Voloboieva
doaj   +1 more source

Nephronectin (NPNT) is a Crucial Determinant of Idiopathic Pulmonary Fibrosis: Modulating Cellular Senescence via the ITGA3/YAP1 Signaling Axis

open access: yesAdvanced Science, EarlyView.
Through a comprehensive multi‐omics analysis, this study identifies a marked reduction in Nephronectin (NPNT) expression within fibrotic lung tissue. This reduction impairs the binding capability to the ITGA3 receptor, consequently causing YAP1 to persist in the cytoplasm, where it undergoes degradation.
Jiayu Guo   +20 more
wiley   +1 more source

Combined methodologies for gaining much information from ancient dental calculus: testing experimental strategies for simultaneously analysing DNA and food residues

open access: yesArchaeological and Anthropological Sciences, 2020
Alessandra Modi   +9 more
semanticscholar   +1 more source

Inhibiting FAT1 Blocks Metabolic Bypass to Enhance Antitumor Efficacy of TCA Cycle Inhibition through Suppressing CPT1A‐Dependent Fatty Acid Oxidation

open access: yesAdvanced Science, EarlyView.
This study demonstrates that mutant FAT1 promotes ASCL2‐driven, CPT1A‐dependent fatty acid oxidation, leading to resistance to CPI‐613‐mediated TCA cycle inhibition in head and neck cancer. In vivo gene depletion of mutant FAT1 with LNP‐sgFAT1 suppresses tumor growth and restores CPI‐613 sensitivity, revealing a targetable metabolic bypass with ...
Fanghui Chen   +11 more
wiley   +1 more source

Mechanical Stress Induced NOX2 Promotes Endothelial Dysfunction in Ventilator‐Induced Lung Injury: Potential Treatment with Quercetin

open access: yesAdvanced Science, EarlyView.
Abnormal mechanical stretch induced by mechanical ventilation (MV) disrupts endothelial junctions via the NOX2/ROS/CaMKII/ERK1/2 axis both in human aortic endothelial cells (HAECs) in vitro and in ventilator‐induced lung injury (VILI) in mice. Quercetin, an antioxidant predicted to bind to NOX2, can effectively prevent mechanical stretch‐induced ...
Tao Jiang   +8 more
wiley   +1 more source

Automated periodontal assessment in orthodontic patients: a dual CNN framework. [PDF]

open access: yesClin Oral Investig
Yurdakurban E   +6 more
europepmc   +1 more source

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