Results 211 to 220 of about 11,967 (299)

Exploring the co‐morbid relationship between Alzheimer's disease and lung cancer in the 5xFAD transgenic mouse model

open access: yesAnimal Models and Experimental Medicine, EarlyView.
Schematic diagram of inverse comorbidities of Alzheimer's disease and lung cancer. Abstract Background Alzheimer's disease (AD) and lung cancer are leading causes of mortality among the older population. Epidemiological evidence suggests an antagonistic relationship between them, whereby patients with AD exhibit a reduced risk of developing cancer and ...
Mingfeng Li   +11 more
wiley   +1 more source

In vivo toxic and lethal cardiorespiratory effects of a synthetic quaternary ammonium salt derivative of haloperidol in mice

open access: yesAnimal Models and Experimental Medicine, EarlyView.
Hematoxylin–eosin (H&E) stains of the heart, liver, lung, and kidney show acute toxicity. Abstract Background To investigate the toxicity of N‐n‐butyl haloperidol iodide (F2), a quaternary ammonium salt derivative of haloperidol, in mice for potential therapeutic purposes. Methods The acute median lethal dose (LD50) of F2 was determined using the Bliss
Jilin Liao   +6 more
wiley   +1 more source

Clusters explaining the relation between menopause and self-reported periodontal disease: a cross-sectional study. [PDF]

open access: yesPeerJ
Fadel HT   +7 more
europepmc   +1 more source

Use of laryngeal muscle evoked potential recording for experimental vagus nerve stimulation

open access: yesAnimal Models and Experimental Medicine, EarlyView.
Laryngeal muscle evoked potentials (LMEPs) reflect the activation of laryngeal muscles induced by vagus nerve stimulation (VNS) via vagal Aα‐motor fibers. LMEP recordings are minimally invasive and provide a feasible, reliable method for assessing the integrity of the electrode‐nerve interface during experimental VNS in rodents.
Helen Bachmann   +3 more
wiley   +1 more source

Alterations in gut microbiota and metabolites contribute to postoperative sleep disturbances

open access: yesAnimal Models and Experimental Medicine, EarlyView.
In this study, we classified postoperative patients into poor sleepers (PS) and good sleepers (GS) based on the bispectral index (BIS), and transplanted their fecal microbiota to pseudo‐germ‐free rats to analyze the sleep changes in rats and the potential mechanism.
Hui Zhong   +7 more
wiley   +1 more source

An optimized perfusate for enhanced rat ex vivo lung perfusion and lung transplant models

open access: yesAnimal Models and Experimental Medicine, EarlyView.
We explored a low‐cost and efficient perfusate composition for use in rat ex vivo lung perfusion (EVLP) and lung transplant models. This perfusate demonstrates better biocompatibility, likely due to a reduction in immune responses associated with high doses of xenogenic proteins, resulting in less lung injury posttransplantation.
Jie Zhang, Xuanlin Zhang, Jianxing He
wiley   +1 more source

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