Results 61 to 70 of about 47,945 (344)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Oral screening of dental calculus, gingivitis and dental caries through segmentation on intraoral photographic images using deep learning

BMC Oral Health
Objective Intraoral photographic images are instrumental in the early screening and clinical diagnosis of oral diseases. In addition, people have been trying to apply artificial intelligence to these images.
Yi Liu, Yuxi Cheng, Yang Song, Daoheng Cai, Niankun Zhang   +4 more
doaj   +1 more source

Establishment of a coculture system for Porphyromonas gingivalis and head and neck squamous cell carcinoma using spheroid culture and LATS inhibition

FEBS Open Bio, EarlyView.
We established a spheroid coculture system enabling viable Porphyromonas gingivalis–HNSCC interactions under normoxic conditions. Inhibition of LATS1/2 maintains tumor cells in an undifferentiated state, which may promote spheroid growth and create a more permissive environment for bacterial persistence.
Yurika Nakajima, Shogo Okazaki, Muneaki Tamura, Shuichi Sato, Kenichi Imai   +4 more
wiley   +1 more source

Periodontal status among 12-year-old schoolchildren: a population-based cross-sectional study in Quito, Ecuador

Brazilian Oral Research
This study aimed to estimate the prevalence and extent of bleeding on probing and calculus in 12-year-old schoolchildren of Quito, Ecuador, and evaluate the associated factors.
Marco MEDINA-VEGA, Mariela Cumandá Balseca IBARRA, Maritza Del Carmen QUEZADA-CONDE, Isabella Neme Ribeiro dos REIS, Antonio Carlos FRIAS, Daniela Prócida RAGGIO, Edgard MICHEL-CROSATO, Fausto Medeiros MENDES, Claudio Mendes PANNUTI, Giuseppe Alexandre ROMITO   +9 more
doaj   +1 more source

Relapsing–Remitting Multiple Sclerosis Is Associated With a Dysbiotic Oral Microbiome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Multiple sclerosis (MS) is a chronic autoimmune disorder characterized by inflammation, demyelination, and neurological impairment. While the gut microbiota's role in MS is extensively studied, the association between the oral microbiota and MS remains underexplored, particularly in North American cohorts.
Sukirth M. Ganesan, Meeta Yadav, Sudeep Ghimire, Peter C. Lehman, Apurva J. Patel, Sydney Woods, Heena Olalde, Jemmie Hoang, Mishelle Paullus, Catherine Cherwin, Christine Gill, Tracey Cho, Ashutosh K. Mangalam   +12 more
wiley   +1 more source

Assessment of Dental Calculus, Plaque and GingivalInflammation in Patients with Urinary Stone

Journal of Baghdad College of Dentistry, 2019
Background: Dental calculus is mineralized dental plaque formed on teeth and dental prosthesis surfaces in the oral cavity. Urinary stone is a crystal aggregation formed in urinary system due to minerals saturation present in urine.
Maher B Mohammed, Maha Sh. Mahmood
doaj   +1 more source

Metagenomic analysis of ancient dental calculus reveals unexplored diversity of oral archaeal Methanobrevibacter

Microbiome, 2021
Background Dental calculus (mineralised dental plaque) preserves many types of microfossils and biomolecules, including microbial and host DNA, and ancient calculus are thus an important source of information regarding our ancestral human oral microbiome.
Lena Granehäll, Kun D. Huang, Adrian Tett, Paolo Manghi, Alice Paladin, Niall O’Sullivan, Omar Rota-Stabelli, Nicola Segata, Albert Zink, Frank Maixner   +9 more
doaj   +1 more source

Biocultural Implications from Scanning Electron Microscopy of Prehistoric Human Dental Calculus, Ohio [PDF]

, 2008
Poster: 3rd Place (The Ohio State University Edward F. Hayes Graduate Research Forum)Dental calculus, though it provides a unique calcium reservoir of bacteria and dietary debris seldom preserved elsewhere in the archaeological record, is an overlooked ...
Blatt, Samantha
core  

Microremains from El Mirón Cave human dental calculus suggest a mixed plant/animal subsistence economy during the Magdalenian in Northern Iberia [PDF]

, 2015
Despite more than a century of detailed investigation of the Magdalenian period in Northern Iberia, our understanding of the diets during this period is limited.
González Morales, Manuel R., Henry, Amanda G., Power, Robert C., Salazar García, Domingo Carlos, Straus, Lawrence Guy   +4 more
core   +2 more sources

Monocyte LOXHD1 and RHOB Expression Predictive of Progressive Systemic Sclerosis–Associated Interstitial Lung Disease

Arthritis Care &Research, EarlyView.
Objective A leading cause of death among patients with scleroderma (SSc), interstitial lung disease (ILD) remains challenging to prognosticate. The discovery of biomarkers that accurately determine which patients would benefit from close monitoring and aggressive therapy would be an essential clinical tool.
Cristina M. Padilla, Robert Lafyatis, Kevin F. Gibson, Christina Morse, Eleanor Valenzi, Xiaoping Chen, Xiaoyun Li, Yanwu Zhao, Yongseok Park, Dana Ascherman, Jonathan Minden, Robyn Domsic, Yingze Zhang, Daniel J. Kass   +13 more
wiley   +1 more source