Results 181 to 190 of about 20,465 (306)

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Stone composition in patients undergoing surgical treatment for kidney stones: a cross-sectional study at a tertiary hospital in Vietnam. [PDF]

BMC Urol
Nguyen XC, Do AT, Ho HL, Nguyen VH.
europepmc   +1 more source

Necessary p-th order optimality conditions for irregular Lagrange problem in calculus of variations

, 2014
The paper is devoted to singular calculus of variations problems with constraints which are not regular mappings at the solution point, e.i. its derivatives are not surjective.
Prusińska, Agnieszka, Tret'yakov, Alexey, Agnieszka Prusińska, Alexey Tret\u27yakov   +3 more
core  

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Health and lifestyle in the Iron Age Italian community of Pontecagnano (Campania, Italy, 7th-6th century BCE). [PDF]

PLoS One
Germano R, Higgins OA, Cristiani E, Galbusera A, Esposito C, Neves D, Pellegrino C, Sperduti A, Manzi G, Bondioli L, Nava A.   +10 more
europepmc   +1 more source

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source

Red Blood Cell Membrane Mechanics Using Discrete Exterior Calculus (DEC) and Optimization. [PDF]

Int J Numer Method Biomed Eng
Afas KC, Goldman D.
europepmc   +1 more source

Calculus of variations and optimal control theory

, 1970
Processes and applications of calculus of variations in optimal control ...
Sagan, H.
core  

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

FEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes, Maria X. Isaksen, Frida Julbø, Manohar Pradhan, Andreas Kleppe, Sepp De Raedt, Ole‐Johan Skrede, Turid Torheim, John Arne Nesheim, Hans Martin Mohn, Hanne A. Askautrud, Karolina Cyll, Wanja Kildal, Emma Rewcastle, Melinda Lillesand, Vebjørn Kvikstad, Emiel Janssen, Robert Jones, Odd Terje Brustugun, Bjørn Brennhovd, Erik Skaaheim Haug, Lill‐Tove Rasmussen Busund, Elin Richardsen, Sigve Andersen, Tom Dønnem, Kristina Lindemann, Gunnar Kristensen, Neil A. Shepherd, Marco Novelli, Knut Liestøl, David Kerr, Håvard E. Danielsen, Tarjei S. Hveem   +32 more
wiley   +1 more source

Dental Calculus Deposition: Correlation With Salivary Statherin and Calcium Levels. [PDF]

Int J Dent
Hase P, Shah V, Gunjal S, Manjunatha BS, Pateel DGS.   +4 more
europepmc   +1 more source