Viscosity of concentrated mRNA solutions: Implications for downstream processing
Abstract Messenger RNA (mRNA) therapeutics can be used to protect against infectious disease and for the treatment of cancers and genetic disorders. In order to obtain the desired therapeutic dosage, it is necessary to concentrate the mRNA to levels where the viscosity of the mRNA solutions can become significant.
Amin Javidanbardan +3 more
wiley +1 more source
Developing a Decision-Support Tool to Improve the Performance and Sustainability of Cow-Calf Grazing Systems Using Satellite Remote Sensing and Mechanistic Nutrition Models. [PDF]
Fernandes MHMR +3 more
europepmc +1 more source
5‐Substituted 2‐(naphthalen‐2‐yl)‐4H‐chromen‐4‐ones are reported as a novel class of highly potent and selective triplex DNA ligands. These ligands induce triplex formation at submicromolar concentrations and inhibit enzymatic activity via ligand‐mediated triplex formation.
Nghia Tran +4 more
wiley +1 more source
Necropsy-Based Analysis of Causes of Neonatal Mortality in Dairy Calves in Poland. [PDF]
Bednarski M, Kupczynski R.
europepmc +1 more source
Dynamic Control of Nucleic Acids Self‐Assembly and Expression Using Photoswitches
We review here the recent progress made in the design of molecular photoswitches, and highlight their implementation for the dynamic control over nucleic acids self‐assembly and expression. ABSTRACT Synthetic nucleic acids have become readily available and now constitute versatile building blocks in materials science—where they can be used to engineer ...
Noemí Nogal +4 more
wiley +1 more source
Helminths, Ticks, and Calf Mortality in Ethiopia: A Prospective Cohort Study. [PDF]
Amenta MW.
europepmc +1 more source
Abstract This work presents a simplified extended‐batch adsorber analogue model (e‐BAAM) to quantify key performance metrics such as purity, recovery, and energy trends for various pressure swing adsorption (PSA) process cycles for CO2$$ {\mathrm{CO}}_2 $$ capture.
Gwyneth Liske, Arvind Rajendran
wiley +1 more source
Accuracy of sarcopenia screening tools among older adults with stroke undergoing inpatient rehabilitation. [PDF]
Supasirimontri K +2 more
europepmc +1 more source
ABSTRACT Bispecific T cell engagers bring together T cells with malignant B cell targets to enable synapse formation and disease eradication of hematological malignancies. The proportion of T cells and their ability to bind to their targets varies between patients and may be a biomarker of response.
Joanne E. Davis +5 more
wiley +1 more source
Associations of antimicrobial and multidrug resistance in <i>Escherichia coli</i> from the fecal flora and housing environment of calves on dairy farms with atmospheric variables. [PDF]
Bernier Gosselin V +4 more
europepmc +1 more source

