Results 191 to 200 of about 6,503,587 (307)

Cationic‐Hydrophilic Di‐Block Copolymers: Surface‐Shielded Vectors for Gene Delivery

open access: yesJournal of Polymer Science, Volume 63, Issue 6, Page 1419-1432, 15 March 2025.
This study develops synthetic polycationic di‐block carriers for nucleic acid (NA) delivery in gene therapy. Consisting of a cationic block and a hydrophilic block, these carriers efficiently form complexes with NAs and shield them with a protective bioinert layer, enhancing stability during circulation in the bloodstream while reducing undesirable ...
Eliška Hrdá   +4 more
wiley   +1 more source

Transcriptome Inference and Systematic Approaches to Investigate TCM Compounds With Beneficial Metabolic Effects

open access: yesPhytotherapy Research, EarlyView.
ABSTRACT Obesity is a major risk factor for type 2 diabetes. Some traditional Chinese medicine (TCM) compounds can improve obesity by increasing energy consumption. This study aimed to identify and verify TCM compounds that promote adipose thermogenesis to alleviate obesity via transcriptomic analysis, molecular docking, network pharmacology, and ...
Jing Li   +6 more
wiley   +1 more source

Few Annotations, High Accuracy: Transfer Learning and Data Augmentation Improve Passive Acoustic Monitoring of the Vulnerable African Manatee

open access: yesRemote Sensing in Ecology and Conservation, EarlyView.
Can deep learning reliably detect a threatened species in passive acoustic monitoring with few annotations? Across 52 sites and 600 recording days, we compared two deep learning recognizers with the traditional machine learning Kaleidoscope for detecting African manatee vocalizations.
Lucas Dubus   +7 more
wiley   +1 more source

Camels as a Climate‐Resilient Linchpin for Sustainable Development in Global Drylands

open access: yesSustainable Development, EarlyView.
ABSTRACT Camels represent a significant, yet underutilized, asset for advancing integrated sustainable development in the world's expanding drylands. Previous reviews have examined camels' physiology, milk composition, or pastoral systems in isolation; this review examines their potential as a climate‐resilient linchpin for food systems by synthesizing
Ayana Angassa   +2 more
wiley   +1 more source

Surface‐Functionalized Poly(2‐Oxazoline)‐Based Grids Produced by Two‐Photon Polymerization as 3D‐Structured Hydrogels Promoting Cell Adhesion

open access: yesSmall, EarlyView.
Sidechain‐functionalized poly(2‐oxazoline) cross‐linkers were utilized to print grids with varying mesh sizes by two‐photon polymerization (2PP grids). The amino‐functionalized hydrogels were subsequently used to covalently couple the RGD‐containing peptide sequence GCWRGDSP (RGD) to the amino groups in the side chains. In cell adhesion tests with L929
Tim Hoffmann   +11 more
wiley   +1 more source

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