Results 161 to 170 of about 1,301,452 (266)

Threonine 348 regulates the subcellular localization of PTEN

FEBS Open Bio, EarlyView.
Thr348 in the C2 domain is a key contributor to PTEN subcellular localization. The PTEN350 fragment and PTENA4 accumulated in the nucleus, whereas PTENK13R,A4 predominantly localized to the plasma membrane. In contrast, substitution of Thr348 with Asp (T348D) disrupted these characteristic localization patterns, resulting in predominant cytoplasmic ...
Takashi Kato, Suzu Tanaka, Miyu Ohashi
wiley   +1 more source

Associations of PM_2.5 exposure with diabetes-related mortality for California residents. [PDF]

Front Public Health
Zheng R, Su JG, Shahriary E, Al-Kindi S, Jerrett M, Brown TT, McConnell R, Balmes J.   +7 more
europepmc   +1 more source

Salmonella enterica serovar typhi limits the potency of typhoid toxin and ADP‐ribosylating toxin AB to establish a persistent infection

FEBS Open Bio, EarlyView.
The two catalytic subunits of typhoid toxin dissociate from the holotoxin in the ER of an intoxicated cell, but only CdtB exits the ER to generate immunosuppressive effects. PltA is retained in the ER and sequestered from its cytosolic target, thus allowing the anti‐inflammatory effects of CdtB to promote intestinal colonization.
Maria C. Zabala‐Rodriguez, Juliette K. Tinker, Teresa Frisan, Taj Azarian, Ken Teter   +4 more
wiley   +1 more source

Noninvasive Speech Restoration After Total Laryngectomy Using Surface Electromyography: Pilot Study. [PDF]

Laryngoscope Investig Otolaryngol
Kaushal NK, Comstock DC, Belafsky PC, Ramirez-Aristizabal A, Miller LM.   +4 more
europepmc   +1 more source

A minimal cellulosome‐like system in Cellulosilyticum lentocellum

FEBS Open Bio, EarlyView.
Cellulose‐degrading bacteria typically use cellulosomes, large multi‐enzyme complexes on a scaffold protein. In Cellulosilyticum lentocellum, we characterise a far smaller arrangement, a single scaffold bound to one cellulase through a single cohesin‐dockerin interaction.
John Allan, Amias Alstrom‐Moore, Gary W Black   +2 more
wiley   +1 more source

FAP-Directed CAR-NKT Cells for Multi-Target Suppression of Atherosclerotic Progression. [PDF]

Circ Res
Zhu E, Li YR, Cho JM, Kropp R, Zhang Y, Sanaiha Y, Kwon OJ, Zhu Y, Park SK, Arianpour B, Justo M, Zhao P, Wang S, Gu M, Benharash P, Yang L, Hsiai TK.   +16 more
europepmc   +1 more source

Cell surface CD11c as a neutrophil aging marker molecule

FEBS Open Bio, EarlyView.
Cell surface CD11chi neutrophils were more aged and had better phagocytic function than CD11c−/lo neutrophils. Transcriptomic analysis of CD11chi neutrophils and CD11c−/lo neutrophils in pediatric population showed that the most difference was seen in infants.
Sophia Koutsogiannaki, Fahd Alhamdan, Erik Malm, Marie Bermudez, Samuel Y. Kim, Koichi Yuki   +5 more
wiley   +1 more source

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

Prenatal exposure to wildfire fine particulate matter and fetal growth outcomes in the United States: Findings from the ECHO Cohort. [PDF]

Environ Epidemiol
Sherris AR, Dearborn LC, Goin DE, Loftus CT, Szpiro AA, Casey JA, Ilango SD, Angal J, Bennett DH, Buxton MA, Camargo CA, Carroll KN, Childs ML, Cioffi C, Croen LA, Dabelea D, Eick SM, Farzan SF, Ferrara A, Garcia E, Gemmill A, Gilliland F, Habre R, Hertz-Picciotto I, Hipwell AE, Hirtz D, Karagas MR, Koinis-Mitchell D, Kress AM, Leve LD, Liang D, Lyall K, McCormack LA, McEvoy CT, Mirzakhani H, Morello-Frosch R, Niu Z, O'Connor TG, Peterson AK, Schmidt RJ, Karr CJ, Padula AM.   +41 more
europepmc   +1 more source