Results 221 to 230 of about 293,289 (282)

Relative density effects on the bearing capacity of unsaturated sand [PDF]

, 2019
Imam, Reza, Maghvan, Sajjad Vaseghi, McCartney, John S   +2 more
core  

l‑Boronophenylalanine (l-BPA) Dipeptide Prodrugs Enhance Boron Delivery to Tumors, Facilitate Tumor Eradication and Induce Tumor Vaccine Effect in Mice Following Neutron Irradiation. [PDF]

ACS Pharmacol Transl Sci
Torgov M, Raitano A, Quintana JC, Martin T, Kulenovic L, Dlamini S, Zhang C, Malinao MC, Ikeura M, Capo L, Morrison K, Matsumoto K, Komatsu A, Higashi Y, Takushi T, Sakurai Y, Dorn R, Suzuki M, Tamanoi F, Morrison K.   +19 more
europepmc   +1 more source

Delivery of Pleckstrin‐Homology Domains Suppresses PI3K/Akt Signaling and Breast Cancer Metastasis

Advanced Science, EarlyView.
Current therapies curb tumor growth but not metastasis. Obscurin, a giant metastasis suppressor lost in breast cancer, restrains PI3K/Akt signaling but is impractical to restore. We deploy a mini‐obscurin, comprising the obscurin‐PH‐domain, which sequesters PI3K‐p85, potently suppressing invasion and metastasis.
Matthew Eason, Anindya Sen, Suhan Cho, Se Jong Lee, Keyata Thompson, Md Musavvir Mahmud, Poornima Dubey, Talia Guardia, Anthony Kim, Stuart Martin, Nathan Wright, Konstantinos Konstantopoulos, Aikaterini Kontrogianni‐Konstantopoulos   +12 more
wiley   +1 more source

Photodriven Sm-Catalyzed Asymmetric Ketyl-Olefin Coupling. [PDF]

J Am Chem Soc
Chen LM, Tarnopol DE, Reisman SE, Peters JC.   +3 more
europepmc   +1 more source

A Dual‐Responsive Versatile Nanohybrid Orchestrating Tumor Elimination and Tumor‐Associated Osteolysis Restoration via Sequential Release

Advanced Science, EarlyView.
The versatile CaO2@CuMOF@HAP nanohybrid demonstrates an outstanding MMP9/pH‐triggered release performance for sequential release of osteogenic growth peptide into deep‐seated tumor‐infiltrated bone destruction areas and dual ions into tumor cells, enabling efficient tumor‐associated osteolysis restoration and tumor elimination for more comprehensive ...
Lan Liu, Han‐Zhe Liu, Zhe‐Nan Liu, Tong Wang, Li‐Li Yu, Qiu‐Jing Li, Zi‐Yi Chen, Guo‐Feng Luo, Zheng‐Jun Shang   +8 more
wiley   +1 more source

Toward the simultaneous detection of multiple diseases with a highly cost-effective cell-free DNA methylome test. [PDF]

Proc Natl Acad Sci U S A
Zeng W, Liu CC, Li S, Zhou Y, Stackpole ML, Xiao Y, Hu R, Tang C, Liu Q, Zeng W, Yeh A, Melehy A, Tran B, Noor Z, Yokomizo M, Amara D, Gumate S, Ahuja P, Li DY, Zhao J, Rose I, Walker C, Malik S, Zhu Y, Tseng HR, Garon EB, French SW, Magyar CE, Dry SM, Lajonchere CM, Geschwind D, Choi G, Saab S, Shetty A, Wong CR, King KG, Lu DS, Raman SS, Xiang X, Shetty K, Mishra L, Memarzadeh S, Liu Y, Alber F, Hsu W, Krysan K, Dubinett SM, Aberle DR, Agopian V, Han SB, Wong WH, Ni X, Li W, Zhou XJ.   +53 more
europepmc   +1 more source

Tetrastigma Hemsleyanum Polysaccharide Suppresses Triple‐Negative Breast Cancer by Disrupting the Hippo‐YAP/TEAD4‐PDIA4 Axis and Endoplasmic Reticulum Stress Adaptation

Advanced Science, EarlyView.
ABSTRACT Triple‐negative breast cancer (TNBC) exhibits addiction to chronic endoplasmic reticulum (ER) stress, which sustains an aggressive metastatic phenotype through activation of the unfolded protein response (UPR). Here, we identify a previously unrecognized “ER‐stress addiction” axis in which the Hippo pathway effector TEAD4 directly ...
Yini Shang, Wentao Si, Youxue Zhang, Jialin Liu, Huaixi Zhang, Yafei Li, Hongmeng Su, Wei Jiang, Zhishan Ding, Lihong Wang   +9 more
wiley   +1 more source

Taxonomic revision of two dominant <i>Munidopsis</i> species (Decapoda, Anomura, Munidopsidae) from the cold seeps in the northern South China Sea: new records and complementary descriptions. [PDF]

Zookeys
Dong D, Seid CA, Li X, Rouse GW.
europepmc   +1 more source

Dual‐Responsive Dynamic Covalent Bond‐Based Assembly of Lipid‐Nanozyme Systems via Multi‐Target Synergy and Efficient Target Enrichment for Ischemic Stroke Therapy

Advanced Science, EarlyView.
This system adopts a biomimetic phospholipid structure, covalently binding iNOS inhibitors, neuroprotective agent PCA and vitamin E derivatives through pH/ROS dual‐responsive bonds, and assembles them with Prussian blue nanozyme to form PBB@AHA. It can efficiently penetrate the blood‐brain barrier and simultaneously release multiple active components ...
Mengcheng Guo, Qingran Guan, Guanyu Qiao, Lixue Zhang, Man Liu, Zhen Li, Qingbiao Yang, Meili Shen, Linlin Liu, Yapeng Li   +9 more
wiley   +1 more source

Decoupling Cyanide Activation from C-C Bond Formation in Ni-Catalyzed Cyanation of Strained Ketones Using Benzonitriles. [PDF]

J Am Chem Soc
Coddington NJ, Bradley RD, Luna YA, Loper MD, Saucedo PJ, Ouyang R, Lo WL, Carta V, Bahamonde A.   +8 more
europepmc   +1 more source