Results 21 to 30 of about 15,204 (245)

Synaptic Dysfunction in the Anterior Cingulate Cortex Underlies Pain‐Anxiety Comorbidity in a Mandibular Asymmetry Mouse Model

Advanced Science, EarlyView.
This study establishes a mandibular asymmetry (MA) mouse model that recapitulates chronic orofacial pain and anxiety comorbidity. Anterior cingulate cortex (ACC) hyperactivation and synaptic dysfunction are identified as central neural mechanisms underlying these pathologies, with chemogenetic inhibition of ACC CaMKII+ neurons effectively reversing ...
Zhaoyichun Zhang, Yanran Zhang, Jialin Si, Honghui Mao, Feng He, Jin Ning, Guaiguai Ma, Xiaohua Chen, Haoxiang Xiao, Yuanyuan Zhu, Haifeng Zhang, Yifan Lu, Qian Liu, Meng Nian, Shiquan Sun, Shibin Yu, Shengxi Wu, Ze Fan, Zuolin Jin, Jing Huang   +19 more
wiley   +1 more source

Stress‐Induced Activation of Prolactin‐NR4A1‐Midkine Axis Exacerbates Skin Inflammation

Advanced Science, EarlyView.
Chronic psychological stress activates prolactin signaling to reprogram dermal fibroblasts into APCDD1+ inflammatory effectors via NR4A1, driving midkine secretion. This paracrine hub amplifies keratinocyte proliferation and immune recruitment, thus exacerbating skin inflammation.
Zhiguo Li, Huiyi Quan, Wanting Liu, Jiaoling Chen, Mengyang Chu, Xin Tang, Ke Xue, Xuan Liu, Jingyi Ma, Yaxing Bai, Ruina Dong, Bing Li, Junfeng Hao, Wei Guo, Qingyang Li, Erle Dang, Johann E Gudjonsson, Gang Wang, Shuai Shao   +18 more
wiley   +1 more source

Using community‐based system dynamics to understand connections between housing and education: A case study with implications for homelessness prevention school‐housing partnership

American Journal of Community Psychology, EarlyView.
Abstract In some communities, schools and housing agencies are innovatively partnering to prevent family homelessness and protect students from the negative outcomes associated with housing hardship. While there is increasing interest in expanding the array of housing solutions via school‐housing partnership, more research is needed to understand the ...
Jessica K. McCabe Johnson, Kelsey Werner, Sarah Bartley, Ellen Dickenson, Alicia Woodsby, Eva Rachel Tine, Gautam N. Yadama   +6 more
wiley   +1 more source

A Systematic Review of Adverse Childhood Experiences and Epigenetic Age Acceleration in Later Adult Life Measured With Second and Third‐Generation Epigenetic Clocks

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.
ABSTRACT We examined the relationship between adverse childhood experiences (ACEs) and epigenetic age acceleration (EAA) in adulthood as measured by second and third generation epigenetic clocks by performing a systematic review of the literature. The electronic databases MEDLINE and EMBASE were searched on 17 July 2023.
Matthew Green, Laura Horsfall, Azam Saied   +2 more
wiley   +1 more source

Task Force on Climate‐Related Financial Disclosures: A Systematic Literature Review and Future Research Agenda

Business Strategy and the Environment, EarlyView.
ABSTRACT We conduct a timely comprehensive review of the existing literature on Task Force on Climate‐Related Financial Disclosures (TCFD). Our aim is to provide a synthesis and extension of the current literature as follows: (i) review theoretical (i.e., socio‐political, economic‐based and market‐based) perspectives employed by existing studies, (ii ...
Yunice Karina Tumewang, Collins G. Ntim, Faizul Haque   +2 more
wiley   +1 more source

Two Views of Invalid Response Set and Malingering Attributions in Forensic Assessment: Credibility and Non‐Credibility

Behavioral Sciences &the Law, EarlyView.
ABSTRACT This article reviews two major sets of six articles on malingering and invalid response set, which have diametrically opposite conclusions on the value of performance and symptom validity tests (PVTs and SVTs) in forensic and related disability assessments (FDRA). First, we review the six‐article series by the Leonhards, which takes the stance
Gerald Young, Laszlo A. Erdodi, Luciano Giromini   +2 more
wiley   +1 more source

Modelling the Incremental Value of Personality Facets: The Domains‐Incremental Facets‐Acquiescence Bifactor Model

European Journal of Personality, EarlyView., 2020
Abstract Personality can be described at different levels of abstraction. Whereas the Big Five domains are the dominant level of analysis, several researchers have called for more fine‐grained approaches, such as facet‐level analysis. Personality facets allow more comprehensive descriptions, more accurate predictions of outcomes, and a better ...
Daniel Danner, Clemens M. Lechner, Christopher J. Soto, Oliver P. John, René Mõttus   +4 more
wiley   +1 more source

Framing Modern Slavery: Do Stakeholders Talk Past Each Other?

Canadian Journal of Administrative Sciences / Revue Canadienne des Sciences de l'Administration, EarlyView.
ABSTRACT Modern slavery literature has thus far mostly adopted a downstream perspective, in the sense that researchers investigated corporate actors' responses after the enactment of transparency legislation. The common finding is that corporate disclosure is poor and ineffective, contributing to a failure to eradicate modern slavery.
Sylvain Durocher, Darlene Himick, Leigh Ellen Walsh   +2 more
wiley   +1 more source

Clinical Trials With Pragmatic Elements: A Review of Use Cases and Real‐World Data Utilization

Clinical Pharmacology &Therapeutics, EarlyView.
Clinical trials with pragmatic elements can capture diverse patient populations, enable efficient follow‐up, and reflect routine clinical practices; yet there is limited understanding of their design features, characteristics, and use of real‐world data (RWD). Based on a targeted search of PubMed/EMBASE (Jan‐2016 to Jul‐2024), a review was conducted to
Le Su, Lei Chen, Seema Betigeri, Nancy Dreyer, Helga Gardarsdottir, Rachele Hendricks‐Sturrup, Mehmet Burcu   +6 more
wiley   +1 more source

Self‐Serving CEO Activism? How the Business‐Relatedness of CEO Activism and CEO Morality Interact and Spill Over to CSR Motives

Corporate Social Responsibility and Environmental Management, EarlyView.
ABSTRACT Chief Executive Officer (CEO) activism, defined as chief executive officers publicly engaging with contentious sociopolitical issues, can evoke mixed stakeholder reactions and even harm a corporate reputation. Although the business‐relatedness of CEO activism has been highlighted as important, evidence of its impact on stakeholders remains ...
Kihyon Kim, Seon Min Lee
wiley   +1 more source