Results 91 to 100 of about 76,600 (323)

Dendrimer Conjugates with PD‐L1‐Binding Peptides Enhance In Vivo Antitumor Immune Response

Advanced Healthcare Materials, EarlyView.
In this paper, a novel nanoparticle scaffold composed of dendrimers conjugated with peptide‐based immune checkpoint inhibitors, enhancing drug delivery efficacy is introduced. By conjugating PD‐L1‐binding peptides to dendrimers, multivalent binding effects are harnessed, resulting in enhanced binding affinity, prolonged half‐life, and improved ...
DaWon Kim, Jin Woong Lee, Piper A. Rawding, Mari Iida, Carter Kim, Kourtney L. Kostecki, Michael J. Poellmann, Bridget Crossman, Ashley S. Liu, YoungSoo Kim, Deric L. Wheeler, Seungpyo Hong   +11 more
wiley   +1 more source

Modeling the Error of Caliper Measurements in Animal Experiments

IEEE Access
Cancer prevention and treatment is one of the most significant public health challenges of the 21st century. Cancer is a serious health problem, and it is the second leading cause of death following cardiovascular diseases.
Melania Puskas, Daniel Andras Drexler
doaj   +1 more source

Incremental and Decremental Maintenance of Planar Width

, 2000
We present an algorithm for maintaining the width of a planar point set dynamically, as points are inserted or deleted. Our algorithm takes time O(kn^epsilon) per update, where k is the amount of change the update causes in the convex hull, n is the ...
Agarwal, Agarwal, Agarwal, Agarwal, Chan, Chazelle, David Eppstein, Eppstein, Eppstein, Houle, Janardan, Nievergelt, Overmars, Preparata, Rote, Schwarz, Toussaint   +16 more
core   +1 more source

Concurrent Biocompatibility and Antimicrobial Functionality of Soft Diamond‐Like Carbon Coating for Healthcare Applications

Advanced Healthcare Materials, EarlyView.
Designing an engineering material that simultaneously promotes the growth of beneficial biological cells while eliminating harmful bacteria is often challenging. However, this study presents a unique carbon coating by manufacturing design capable of achieving both functions, demonstrating strong potential for various applications, including medical ...
Abdul Wasy Zia, Alberto Tuñón‐Molina, Ioannis Anestopoulos, Miguel Martí, Iraklis‐Stavros Panagiotidis, Anam Ijaz, Ángel Serrano‐Aroca, Mihalis I. Panayiotidis, Martin Birkett   +8 more
wiley   +1 more source

Immunosuppressive Cytokine‐Tethered Hydrogel for Treating Rheumatoid Arthritis

Advanced Healthcare Materials, EarlyView.
An injectable hydrogel is developed by chemically tethering IL‐4, an immunosuppressive cytokine, to a hyaluronic acid‐based backbone. The hydrogel reduces joint friction and exerts immunomodulatory effects. In a rheumatoid arthritis (RA) mouse model, it reduced inflammation, preserved cartilage, and promoted anti‐inflammatory immune responses.
Woojin Back, Moonkyoung Jeong, Huyen‐Thao Le, Ji‐Ho Park   +3 more
wiley   +1 more source

Imiquimod‐Loaded Phospholipid‐Free Small Unilamellar Vesicles Activate the Tumor Immune Microenvironment to Treat Liver Cancer and Liver Metastases

Advanced Healthcare Materials, EarlyView.
Imiquimod‐loaded nanoparticles (PFSUV‐IMQ) are found to decrease liver metastasis and liver tumor burden when administered intravenously. Flow cytometry, RNA‐seq and various experiments show that the anti‐tumor response is immune‐mediated by activating dendritic cells resulting in increased CD8 T cell infiltration and activity.
Vanessa Chan, Hsin‐Mei Lee, Haruka Takata, Sheng‐Liang Cheng, Yu‐Ting Yen, Lisa Pfeifer, Luke Rushton, Po‐Han Chao, Feng Zhao, Chun Yat Ong, Nojoud Al‐Fayez, Tatsuhiro Ishida, Yunching Chen, Shyh‐Dar Li   +13 more
wiley   +1 more source

Beyond the Bubble: Technology and the Future of Student Assessment [PDF]

, 2009
Provides an overview of information technology's potential to enable better assessments of student achievement. Outlines promising models for testing complex skills, cognition, and learning and for utilizing such assessments to improve ...
Bill Tucker
core  

DNA Barcoding‐Enabled Tracking of Lipid Nanoparticles: Drug‐Loading‐Dependent Biodistribution and Tumor Microenvironment Targeting

Advanced Healthcare Materials, EarlyView.
In this study, lipid nanoparticles are tracked in vivo using DNA barcodes to determine how varying drug loadings affect their delivery behaviors in mice. A cost‐effective strategy is developed for simultaneously monitoring the biodistribution of a library of lipid nanoparticles (LNPs).
Letao Xu, Rui Chen, Xing Wang, Dawei Liu, Yun liu, Chun‐Xia Zhao   +5 more
wiley   +1 more source

Ultrasound Imaging of Testes and Epididymides of Normal and Infertile Breeding Bulls [PDF]

Pakistan Veterinary Journal, 2011
Echotexture of testes and epididymides from 10 slaughtered male buffaloes was studied. Diameter of testis and mediastinum testis was measured by ultrasound and compared with respective values taken by calipers.
Khalid Mahmood Ali, Nazir Ahmad*, Nafees Akhtar, Shujait Ali, Maqbool Ahmad and Muhammad Younis1
doaj  

Nonlinear Conductive Graphene Composites for Pressure Sensing with a Linear Response and Voltage‐Driven Thermal Correction

Advanced Materials, EarlyView.
A nonlinear conductive graphene composite (NcGc) layer, incorporating a conductive laser‐reduced graphene oxide layer, is assembled into flexible pressure sensors without microstructural designs, achieving high sensitivity (742.3 kPa−1) and a wide linear sensing range (>800 kPa).
Feng Luo, Artur Ciesielski, Paolo Samorì   +2 more
wiley   +1 more source