Results 151 to 160 of about 76,600 (323)

TESTICULAR BIOMETRIC CHARACTERISTICS IN SANTA INÊS SHEEP SUBMITTED TO PROTEIN SUPPLEMENTATION AND ANTI-HELMINTH TREATMENTS CARACTERÍSTICAS BIOMÉTRICAS TESTICULARES EM CARNEIROS SANTA INÊS SUBMETIDOS A DIFERENTES REGIMES DE SUPLEMENTAÇÃO PROTÉICA E TRATAMENTOS ANTI-HELMÍNTICOS

open access: yesCiência Animal Brasileira, 2008
<span><p align="justify">Biometric testicular traits were evaluated on 24 entire male Santa Inês lambs, with mean initial weight of 24.5 kg ± 2.88.
Helder Louvandini   +4 more
doaj  

PTf‐SRiApt Targeting SCAF4‐POLR2A Interaction Suppresses Tumor Growth and Promotes Antitumor Immunity in Triple‐Negative Breast Cancer

open access: yesAdvanced Science, EarlyView.
A phosphorothioate‐modified aptamer PTf‐SRiApt capable of disrupting “undruggable” transcription factor SCAF4‐POLR2A interaction with high inhibitory activity and biological stability is presented here. Through this inhibition, PTf‐SRiApt successfully arrested cell cycle progression, induced cell death, and elevated immune recruitment in SCAF4‐POLR2A ...
Liyan Fei   +13 more
wiley   +1 more source

A Dual Approach with Organoid and CRISPR Screening Reveals ERCC6 as a Determinant of Cisplatin Resistance in Osteosarcoma

open access: yesAdvanced Science, EarlyView.
This study utilizes patient‐derived osteosarcoma organoids and CRISPR screening to identify ERCC6 and HNRNPM as key mediators of cisplatin resistance via the PI3K/AKT pathway and BAX alternative splicing. These findings provide novel insights and potential therapeutic targets for overcoming chemoresistance in osteosarcoma.
Ruiling Xu   +11 more
wiley   +1 more source

Gradient Solvent Replacement‐Mediated Formation of High‐Strength Hydrogel‐Forming Microneedle for Long‐Term Drug Delivery

open access: yesAdvanced Science, EarlyView.
A high‐strength pH‐responsive hydrogel‐forming microneedle integrates gradient solvent replacement to enhance the mechanical properties of the acrylonitrile‐acrylic acid copolymer network, ensuring robust transdermal penetration and long‐term drug release.
Hui Li   +12 more
wiley   +1 more source

Use of Tethered Spectroscopic Probes as Chemical Calipers to Measure Molecular Distances [PDF]

open access: bronze, 2011
Brian W. Jarecki   +5 more
openalex   +1 more source

NDRG1‐Driven Lactate Accumulation Promotes Lung Adenocarcinoma Progression Through the Induction of an Immunosuppressive Microenvironment

open access: yesAdvanced Science, EarlyView.
NDRG1 drives lactate accumulation and histone lactylation in lung adenocarcinoma, promoting immunosuppression via M2 macrophage polarization and CD8⁺ T cell inhibition. High NDRG1 expression correlates with poor prognosis, an immunosuppressive microenvironment, and immunotherapy resistance.
Gujie Wu   +14 more
wiley   +1 more source

Flexible Regulation of Optical Properties Based on Structure Size‐Driven Intermolecular Interactions for Phototherapy

open access: yesAdvanced Science, EarlyView.
Herein, ACQ@AIE bimolecular systems are developed by noncovalently combining an aggregated‐caused quenching (ACQ) molecule with three aggregated‐induced emission (AIE) molecules. Differentials in structural size drive different patterns of intermolecular interactions, leading to distinct and tunable optical properties.
Zhichao Gong   +8 more
wiley   +1 more source

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