Results 161 to 170 of about 76,600 (323)
CLINICAL USE OF METAL AND PLASTIC CALIPERS FOR NUTRITIONAL ASSESSMENT OF PATIENTS UNDER LONG-TERM ENTERAL FEEDING THROUGH ENDOSCOPIC GASTROSTOMY. [PDF]
Ana Teresa Barata+3 more
openalex +1 more source
The DNA demethylase TET3 drives lipid metabolic reprogramming in pancreatic ductal adenocarcinoma via a non‐catalytic mechanism. TET3 recruits histone deacetylases to repress GATA6, sustaining lipogenic enzyme expression and ferroptosis resistance.
Shuai Liu+8 more
wiley +1 more source
Structural analysis reveals a “molecular calipers” mechanism for a LATERAL ORGAN BOUNDARIES DOMAIN transcription factor protein from wheat [PDF]
Wei-Fei Chen+6 more
openalex +1 more source
Novel ATR/PARP1 dual inhibitors are developed for the first time. Advanced lead B8 effectively reduces cell viability in vitro and suppresses tumor growth in vivo, with better potency than ATRi and PARPi alone or in combination. Mechanistically, B8 induces apoptosis, arrests the cell cycle, and inhibits cancer cells colony formation, migration, and ...
Yuan Gao+13 more
wiley +1 more source
A novel artemisinin derivative dimer has been synthesized, and its significant potential as an anti‐cancer agent. The study indicated that ZQJ29 effectively inhibited the proliferation of pancreatic cancer cells in vitro and in vivo. Additionally, these investigations have unveiled ZQJ29 as a new potent PARP1 inhibitor, with the capability to induce ...
Jianping Chen+9 more
wiley +1 more source
Volumetric measurement techniques for assessment of cutaneous neurofibromas: A review
Cutaneous neurofibroma (cNF) is a prevalent clinical manifestation of neurofibromatosis type 1, significantly affecting the well-being and quality of life of the affected individuals.
Xinyu Wang+4 more
doaj
Issues in QT interval measurement
The QT interval, apart from clinical implications is crucial for safety assessment of new drugs under development. A QTc prolongation of even 10 msec in a study group is a warning signal for a new drug.
Pallavi Lanjewar+2 more
doaj
Cosmic Calipers: Precise and Accurate Neutron Star Radius Measurements with Next-Generation Gravitational Wave Detectors [PDF]
Sanika Khadkikar+5 more
openalex +1 more source
Potent Cross‐neutralizing Antibodies Reveal Vulnerabilities of Henipavirus Fusion Glycoprotein
Hendra and Nipah viruses (HNVs) pose significant threats to global health. This work reports potent cross‐neutralizing antibodies targeting the fusion glycoprotein (F) and reveals shared features of these antibodies and vulnerabilities of F, thereby guiding the rational design of countermeasures against HNVs and similar pathogens.
Yi Ren+19 more
wiley +1 more source
Compared with the non‐risk G allele of rs9606, the risk T allele of rs9606 decreases the binding affinity of NUDT21 for LYRM4, triggering 3'UTR shortening that stabilizes LYRM4 mRNA and elevates its expression. Increased LYRM4 expression promoted malignant phenotypes of non‐small cell lung cancer (NSCLC) cells through modulating ferroptosis, supporting
Meng Jin+11 more
wiley +1 more source