Results 101 to 110 of about 1,956,863 (329)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Normalized, Segmented or Called aCGH Data?

Cancer Informatics, 2007
Array comparative genomic hybridization (aCGH) is a high-throughput lab technique to measure genome-wide chromosomal copy numbers. Data from aCGH experiments require extensive pre-processing, which consists of three steps: normalization, segmentation and
Bauke Ylstra, Mark A. van de Wiel, Wessel N. van Wieringen   +2 more
doaj  

Identity work of public hospital nurses during the COVID-19 pandemic in South Africa

Curationis
Background: Nurses play a remarkable role in our healthcare system and contribute to the wellbeing of communities at large. During the coronavirus disease 2019 (COVID-19) pandemic, nurses faced various challenges to provide adequate patient healthcare ...
Nosipho M. Maseko, Roslyn T. De Braine
doaj   +1 more source

Deserts of Development: How God Shapes Leaders in the Wilderness [PDF]

, 2010
A wilderness experience in the life of a believer is often a tool used by God to shape him for some leadership position or specific calling. While the desert one is thrust into may be physical in nature or purely psychological, wilderness experiences ...
Dickson, Jeffrey R
core   +1 more source

A comparative analysis of the statistical properties of large mobile phone calling networks

, 2014
Mobile phone calling is one of the most widely used communication methods in modern society. The records of calls among mobile phone users provide us a valuable proxy for the understanding of human communication patterns embedded in social networks ...
Jiang, Zhi-Qiang, Li, Ming-Xia, Mantegna, Rosario N., Miccichè, Salvatore, Tumminello, Michele, Xie, Wen-Jie, Zhou, Wei-Xing   +6 more
core   +2 more sources

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Florian Bieber: The Rise of Authoritarianism in the Western Balkans

Comparative Southeast European Studies, 2021
Mujanović Jasmin
doaj   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Intersecting Pathways: Exploring the Mediating Role of Calling and Affective Commitment Through Self-Compassion in Job Satisfaction Enhancement

Administrative Sciences
This study aims to reveal the significance of self-compassion, job satisfaction, calling, and affective commitment in the context of safety workers. The sample of the study consists of security personnel working in the public sector.
Hasan Huseyin Uzunbacak, Tahsin Akçakanat, Tugba Erhan, Erhan Aydin, Serkan Türkmen   +4 more
doaj   +1 more source