Results 91 to 100 of about 12,005,683 (347)
A method to reduce ancestry related germline false positives in tumor only somatic variant calling
BMC Medical Genomics, 2017 Significant clinical and research applications are driving large scale adoption of individualized tumor sequencing in cancer in order to identify tumors-specific mutations.
Rebecca F. Halperin +17 more
semanticscholar +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Accurate and scalable variant calling from single cell DNA sequencing data with ProSolo
Nature Communications, 2021 Obtaining accurate variant calls from multiple displacement amplified single cell DNA sequencing data needs dedicated models that account for amplification bias and copy errors.
David Lähnemann +5 more
doaj +1 more source
FEBS Letters, EarlyView.Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley +1 more source
Optimal sequencing depth design for whole genome re-sequencing in pigs
BMC Bioinformatics, 2019 Background As whole-genome sequencing is becoming a routine technique, it is important to identify a cost-effective depth of sequencing for such studies.
Yifan Jiang +4 more
doaj +1 more source
Scientific Reports, 2017 Complementary to reference-based variant detection, recent studies revealed that many novel variants could be detected with de novo assembled genomes.
Leihong Wu +4 more
semanticscholar +1 more source
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Australian telephone network subscription and calling demands: evidence from a stated-preference experiment [PDF]
This paper examines the impact of the subscription-calling rate structure on the demand for residential telephone network subscription and calling. Stated-preference experimental data are used to estimate demand equations.
Bloch, Harry +2 more
core +1 more source
Sprinklers: A Randomized Variable-Size Striping Approach to Reordering-Free Load-Balanced Switching [PDF]
, 2014 Internet traffic continues to grow exponentially, calling for switches that can scale well in both size and speed. While load-balanced switches can achieve such scalability, they suffer from a fundamental packet reordering problem.
Dai, Jim +4 more
core
Muver, a computational framework for accurately calling accumulated mutations
BMC Genomics, 2018 Identification of mutations from next-generation sequencing data typically requires a balance between sensitivity and accuracy. This is particularly true of DNA insertions and deletions (indels), that can impart significant phenotypic consequences on ...
Adam B. Burkholder +5 more
semanticscholar +1 more source