Results 131 to 140 of about 12,005,683 (347)
A SINDA '85 nodal heat transfer rate calculation user subroutine [PDF]
This paper describes a subroutine, GETQ, which was developed to compute the heat transfer rates through all conductors attached to a node within a SINDA '85 thermal submodel. The subroutine was written for version 2.3 of SINDA '85. Upon calling GETQ, the
Cheston, Derrick J.
core +1 more source
Molecular Oncology, EarlyView.Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard +12 more
wiley +1 more source
SMaSH: A Benchmarking Toolkit for Human Genome Variant Calling
, 2014 Motivation: Computational methods are essential to extract actionable information from raw sequencing data, and to thus fulfill the promise of next-generation sequencing technology. Unfortunately, computational tools developed to call variants from human
Bresler, Ma'ayan +9 more
core +1 more source
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Condition-dependent signaling affects male sexual attractiveness in field crickets, Gryllus campestris [PDF]
, 2017 The condition dependence of sexually selected traits is an important assumption of sexual selection theory. Several laboratory studies have documented a positive relationship between food availability, body condition, and sexual display.
Brinkhof, Martin W.G. +2 more
core
Does Pulsar B1757--24 Have a Fallback Disk?
, 2000 Radio pulsars are thought to spin-down primarily due to torque from magnetic dipole radiation (MDR) emitted by the time-varying stellar magnetic field as the star rotates.
Caswell J. L. +9 more
core +1 more source
Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
Irrationality rings! - Experimental evidence on mobile tariff choices [PDF]
This paper investigates why consumers choose calling plans that are not always cost-minimizing. Our approach is twofold: we account for general difficulties facing a tariff choice, as well as for biased preferences. We provide evidence from an experiment
Barth, Anne-Kathrin, Graf, Julia
core
Using GWAS Data to Identify Copy Number Variants Contributing to Common Complex Diseases
, 2010 Copy number variants (CNVs) account for more polymorphic base pairs in the human genome than do single nucleotide polymorphisms (SNPs). CNVs encompass genes as well as noncoding DNA, making these polymorphisms good candidates for functional variation ...
Teslovich, Tanya M., Zöllner, Sebastian
core +1 more source
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source