Results 31 to 40 of about 153,169 (263)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Competition-induced stress does not explain deceptive alarm calling in tufted capuchin monkeys [PDF]

, 2014
Tactical deception has long attracted interest because it is often assumed to entail complex cognitive mechanisms. However, systematic evidence of tactical deception is rare and no study has attempted to determine whether such behaviours may be ...
Heistermann, Michael, Wheeler, Brandon C., Michael Heistermann, Tiddi, Barbara, Brandon C. Wheeler, Wheeler, Brandon C, Barbara Tiddi   +6 more
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

(Orthoptera: Gryllotalpidae) Range Expansion and Calling Song in California [PDF]

, 2014
Invasive mole cricket species in the genus Scapteriscus have become significant agricultural pests and are continuing to expand their range in North America.
Dillman, Adler R., Gray, David A, David A. Gray, Paul W. Sternberg, Cronin, Christopher J., Dillman, Adler R, Joseph Tang, Tang, Joseph, Sternberg, Paul W, Sternberg, Paul W., Cronin, Christopher J, Christopher J. Cronin, Adler R. Dillman, Gray, David A.   +13 more
core   +1 more source

The Laws of Motion of the Broker Call Rate in the United States [PDF]

International Journal of Financial Studies, 2019
In this paper, which is the third installment of the author’s trilogy on margin loan pricing, we analyze 1367 monthly observations of the U.S. broker call money rate, e.g., the interest rate at which stockbrokers can borrow to fund their margin loans to retail clients.
openaire   +4 more sources

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Expanding Predictive Assessment of Northern Bobwhite Covey Calling Rates to Incorporate Regional Effects

, 2017
Many surveys based on discrete vocalizations make the invalid assumption that individuals present in the survey area are always available for detection (e.g., calling) during the survey period.
Burger, L. Wes, Jr., Seiler, Ted P., Palmer, William E., Evans, Kristine O., Wellendorf, Shane D., Dailey, Thomas V., Emmerich, Beth A.   +6 more
core   +1 more source

Calling Behavior and Sex Pheromone Release and Storage in the Moth Chloridea virescens

, 2020
This is the post-print version of the following article: "Calling Behavior and Sex Pheromone Release and Storage in the Moth Chloridea virescens", which has been published in final form at https://link.springer.com/article/10.1007/s10886-019-01133-w#auth-
Foster, Stephen, P, Anderson, Karin, G, Casas, Jérome   +2 more
core   +1 more source