Results 231 to 240 of about 3,748,769 (312)

A Skull Bone Marrow‐to‐Brain Axis Links Osteoblastic Activity to Myeloid Cell Trafficking, Cerebral Blood Flow, and Cognition in Alzheimer's Progression

Advanced Science, EarlyView.
This study reveals that Alzheimer's disease–linked APP expression in bone‐forming cells drives skull bone marrow remodeling and alters its vascular connections to the brain. These changes disrupt immune cell trafficking, cerebral blood flow, and cognition. Targeting bone marrow macrophages restores brain function, highlighting a previously unrecognized
Lei Xiong, Dong Sun, Hao‐Han Guo, Daehoon Lee, Zhipeng Liu, Lin Mei, Wen‐Cheng Xiong   +6 more
wiley   +1 more source

Erratum: Coastline changes: A reconsideration of the prevalence of recession on sandy shorelines - CORRIGENDUM. [PDF]

Camb Prism Coast Futur
Woodroffe CD, Evelpidou N, Delgado-Fernandez I, Green D, Sengupta D, Karkani A, Ciavola P.   +6 more
europepmc   +1 more source

Reverse Weak Polarity‐Induced Ordered Layer Control for Enhanced Second‐Harmonic Generation in Ultraviolet Nonlinear Optical Crystals

Advanced Science, EarlyView.
Reverse Weak Polarity‐Induced Ordered Layer Control strategy, optimizing the design of layered structures, has been successfully designed. By leveraging inhomogeneous field of units to replace isotropic fields of metal cations, polar layers realize controllable layer stacking via a “layer→linker→layer” polarity transfer.
Lingli Wu, Chensheng Lin, Bing‐Xuan Li, Huixin Fan, Lingfei Lv, Shunda Yang, Tao Yan, Min Luo   +7 more
wiley   +1 more source

Genomic and spatial analysis of local recurrences following risk-adapted breast radiotherapy in the IMPORT trials. [PDF]

Breast Cancer Res
Lightowlers SV, Roman-Escorza M, Welsh C, Bliss JM, Carroll JS, Chan HYC, Harrison K, Haviland JS, Healy N, Jefford ML, Jena R, Kirby AM, Kirwan CC, Provenzano E, Sydenham MA, Syndikus I, Tanner J, Woitek R, Coles CE, Sawyer EJ.   +19 more
europepmc   +1 more source

Mixed‐Coordination Electrolytes With Molecular Additives for Robust Interphases in High‐Voltage Rechargeable Magnesium Batteries

Advanced Science, EarlyView.
A mixed‐coordination electrolyte (MCE) combined with a molecular additive (MCE‐MA) promotes pseudo ion pair (pIP) formation within a solvent‐separated ion pair (SSIP)–rich environment, enabling a robust interphase that significantly improves the cycle performance of high‐voltage rechargeable magnesium batteries (RMBs).
Dedy Setiawan, Toshihiko Mandai
wiley   +1 more source

Targeting ANGPTL3 and IL‐33/ST2 Ameliorates Diabetic Kidney Disease by Reducing Lipotoxicity, Alleviating Inflammation and Inhibiting Fibrosis

Advanced Science, EarlyView.
Dual targeting of ANGPTL3 and IL‐33/ST2 attenuates diabetic kidney disease by reprogramming lipid–inflammatory crosstalk. This strategy reduces renal lipotoxicity, suppresses inflammatory activation, and limits fibrotic remodeling, thereby preserving kidney structure and function and highlighting a mechanism‐guided therapeutic approach for metabolic ...
Zhuojin Li, Zhonglian Cao, Rongrui Zhou, Xu Cheng, Xiaozhi Hu, Shuwen Xu, Zihan Dou, Ling Du, Dianwen Ju   +8 more
wiley   +1 more source

Maternal cardiometabolic dysfunction and fetal sex-specific alterations to uterine vascular reactivity in an ovine model of obesity during pregnancy. [PDF]

J Physiol
Crew RC, Cochrane ALK, Niu Y, Ford SG, Cahen CLR, Davison SH, Murphy MP, Ozanne SE, Giussani DA.   +8 more
europepmc   +1 more source

A Non‐Canonical Core Transcriptional Regulatory Circuit Orchestrates Chromatin Reprogramming to Drive Osimertinib Resistance in Non‐Small Cell Lung Cancer

Advanced Science, EarlyView.
A non‐canonical core transcriptional regulatory circuit, composed of ID3, SMAD3, and NR2F2, drives Osimertinib resistance in non‐small cell lung cancer through super‐enhancer‐mediated activation of EPAS1, which couples neuroendocrine differentiation with ferroptosis evasion.
Aochu Liu, Zhenguo Liu, Lizhen Jiang, Andong Huang, Xinqing Lin, Xinyue Li, Bingyuan Liu, Shiwen Hu, Qiang Pan, Junjun Huang, Liyuan Yin, Liling Jiang, Wei Yi, Wenjun Mao, Yueyuan Zheng, Xianping Shi   +15 more
wiley   +1 more source

Correction: A bis-macrocyclic peptide ligand mimicking the β-sandwich active site of multicopper oxidases.

Dalton Trans
Dang VT, Drena A, Telser J, Wofford L, Nguyen AI.   +4 more
europepmc   +1 more source

Publisher Correction: Mutant p53 protein accumulation is selectively targetable by proximity-inducing drugs. [PDF]

Nat Chem Biol
Sadagopan A, Carson M, Zamurs EJ, Garaffo N, Chang HJ, Schreiber SL, Meyerson M, Gibson WJ.   +7 more
europepmc   +1 more source