Results 121 to 130 of about 579,058 (319)

The Chirality Chain in Valine: How the Configuration at the Cα Position through the OcisC′CαN Torsional System Leads to Distortion of the Planar Group CαC′(Ocis)Otrans to a Flat Tetrahedron

ChemistryOpen, 2018
Solid‐state structures, based on a Cambridge Structural Database (CSD) search, show that there is a CαN/C′Ocis attraction in the torsional system OcisC′CαN of valine, causing a chirality chain.
Prof. Dr. Henri Brunner, Prof. Dr. Takashi Tsuno   +1 more
doaj   +1 more source

Hepatocyte BDNF Acts as a Novel Immune Checkpoint to Restrain TLR4‐Mediated Acute Hepatitis

Advanced Science, EarlyView.
This study identifies hepatocyte‐derived BDNF as an endogenous TLR4 antagonist that alleviates acute hepatitis. BDNF is downregulated in hepatocytes via REST‐mediated transcriptional repression during ALI/ALF. Mechanistically, BDNF binds to TLR4 on macrophages to suppress inflammation.
Weiwei Zhu, Yaqian Cui, Yongqiang Zhou, Yihui Zheng, Lijiang Huang, Leiming Jin, Qianhui Zhang, Pan Chen, Mengsha Lin, Jiaxi Ye, Yongqiang Xiong, Joo Young Huh, Xiang Hu, Xiaokun Li, Wu Luo, Guang Liang   +15 more
wiley   +1 more source

Virtual screening of n-type organic semiconductors using exhaustive band structure calculations

Science and Technology of Advanced Materials: Methods
We performed a virtual screening of high-mobility n-type organic semiconductor materials using the Cambridge Structural Database (CSD) and large-scale band structure calculations.
Tomoharu Okada, Wataru Fujiwara, Hiroshi Katagiri, Hiroyuki Matsui   +3 more
doaj   +1 more source

1-Methyl-6-nitro-1H-benzimidazole

Acta Crystallographica Section E, 2008
The title compound, C8H7N3O2, a potential antitumour drug and an antioxidant agent, was studied in order to give more insight into structure–function relationships.
Svetozar Katuščák, Tomáš Solčan, Viktor Kettmann, Jan Lokaj   +3 more
doaj   +1 more source

A novel hybrid architecture for agriculture and land use in an integrated modeling framework : MATISSE (Methods and Tools for Integrated Sustainability Assesment) [PDF]

, 2008
As part of a cluster workshop on sustainability of hydrogen transport technologies held in Frankfurt on 21st February 2006, MATISSE researchers conducted break-out discussion groups with, and distributed self-completion questionnaires to, stakeholders in
Cassen, Christophe, Crassous, Renaud, Dorin, Bruno, Gitz, Vincent, Hourcade, Jean-Charles   +4 more
core  

Phosphatidic Acid‐TRIM59‐Olig2 Signaling Couples Metabolic Dysfunction to Myelination Failure in PWMI

Advanced Science, EarlyView.
PA accumulates after hypoxic‐ischemic injury and stabilizes the E3 ligase TRIM59 in OPCs. Stabilized TRIM59 enhances ubiquitination and degradation of Olig2, blocking differentiation and causing hypomyelination in PWMI. Modulating PA synthesis restores Olig2 levels, improves myelination, and ameliorates behavioral deficits, defining a metabolically ...
Xinyu Li, Yanan Liu, Meng Zhang, Yiwei Liu, Meiting Liu, Kaishen Zhu, Zhian Liu, Chao Ren, Ruiqin Yao   +8 more
wiley   +1 more source

Analysis of COF-300 synthesis: probing degradation processes and 3D electron diffraction structure

IUCrJ
Although COF-300 is often used as an example to study the synthesis and structure of (3D) covalent organic frameworks (COFs), knowledge of the underlying synthetic processes is still fragmented.
Laurens Bourda, Subhrajyoti Bhandary, Sho Ito, Christian R. Göb, Pascal Van Der Voort, Kristof Van Hecke   +5 more
doaj   +1 more source

Tetrel Bonding Interactions in Perchlorinated Cyclopenta- and Cyclohexatetrelanes: A Combined DFT and CSD Study

Molecules, 2018
In this manuscript, we combined DFT calculations (PBE0-D3/def2-TZVP level of theory) and a Cambridge Structural Database (CSD) survey to evaluate the ability of perchlorinated cyclopenta- and cyclohexatetrelanes in establishing tetrel bonding ...
Antonio Bauzá, Antonio Frontera
doaj   +1 more source

Identifying porous cage subsets in the Cambridge Structural Database using topological data analysis. [PDF]

Chem Sci, 2022
Li A, Bueno-Perez R, Fairen-Jimenez D.
europepmc   +1 more source

Repeated Disuse Atrophy Imprints a Molecular Memory in Skeletal Muscle: Transcriptional Resilience in Young Adults and Susceptibility in Aged Muscle

Advanced Science, EarlyView.
Repeated disuse imprints a molecular memory in skeletal muscle, conferring transcriptional resilience in young adults but exaggerated susceptibility in aged muscle, driven by epigenetic regulation of aerobic metabolism, mitochondrial and NAD+ pathways.
Daniel C. Turner, Truls Raastad, Max Ullrich, Stian F. Christiansen, Hazel Sutherland, James Boot, Eva Wozniak, Charles Mein, Emilie Dalbram, Jonas T. Treebak, Daniel J. Owens, David C. Hughes, Sue C. Bodine, Jonathan C. Jarvis, Adam P. Sharples   +14 more
wiley   +1 more source