Results 221 to 230 of about 579,058 (319)

The glioblastoma GBMdrug1000 dataset resource provides directions for future small molecule drug discovery. [PDF]

Neurooncol Adv
Pruteanu LL, Béquignon OJM, Broersma Y, Bender A, Ibrahim SM, Bailey DS, Westerman BA.   +6 more
europepmc   +1 more source

A dialogic theoretical foundation for integrating generative AI into pedagogical design

British Journal of Educational Technology, EarlyView.
Generative AI presents a profound challenge to the existing structures and purposes of education. It forces us to reconsider not only how we teach and learn but also, more fundamentally, what education is for. This conceptual paper argues that, in order to integrate AI into education in a way that can meet the major challenges facing humanity, ranging ...
Rupert Wegerif, Imogen Casebourne
wiley   +1 more source

The Spatial Distribution of Local Mobility in Folded Proteins. [PDF]

J Phys Chem B
Rackovsky S.
europepmc   +1 more source

Artificial intelligence chatbots mimic human collective behaviour

British Journal of Psychology, EarlyView.
Abstract Artificial Intelligence (AI) chatbots, such as ChatGPT, have been shown to mimic individual human behaviour in a wide range of psychological and economic tasks. Do groups of AI chatbots also mimic collective behaviour? If so, artificial societies of AI chatbots may aid social scientific research by simulating human collectives.
James K. He, Felix P. S. Wallis, Andrés Gvirtz, Steve Rathje   +3 more
wiley   +1 more source

Decoding the unseen: unsupervised anomaly detection in metal-organic frameworks for discovery beyond the norm. [PDF]

Chem Sci
Alimardani H, Abaei S, Asgari M.
europepmc   +1 more source

Preclinical models for evaluating psychedelics in the treatment of major depressive disorder

British Journal of Pharmacology, EarlyView.
Psychedelic drugs have seen a resurgence in interest as a next generation of psychiatric medicines with potential as rapid‐acting antidepressants (RAADs). Despite promising early clinical trials, the mechanisms which underlie the effects of psychedelics are poorly understood.
Laith Alexander, Dasha Anderson, Luke Baxter, Matthew Claydon, James Rucker, Emma S. J. Robinson   +5 more
wiley   +1 more source

Comparative Assessment of Statistical and Thermodynamic Prediction Methods for Solvate Formation: A Case Study with Curcumin and Its Derivatives. [PDF]

Cryst Growth Des
Ticona-Chambi J, Choquesillo-Lazarte D, Cuffini SL, Infantes L.   +3 more
europepmc   +1 more source

Targeting the noradrenergic‐metabolic axis: A new strategy for sugar‐induced depression subtypes

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Lifestyle is closely related to major depressive disorder (MDD). Given the growing focus on the impact of diet on mental health, this study examined how dietary habits affect the pathophysiology of MDD. Experimental Approach Health check‐up data were analysed. Mice received sucrose under chronic unpredictable mild stress
Takatoshi Sakata, Kazuo Kunisawa, Masaya Hasegawa, Yumiko Seto, Aoi Ogawa, Hitomi Kurahashi, Yasuko Yamamoto, Masao Takemura, Hidetoshi Matunami, Tomoya Sugai, Noriki Kutsumura, Kuniaki Saito, Toshitaka Nabeshima, Akihiro Mouri   +13 more
wiley   +1 more source

TRPtracker: a community database for monitoring praziquantel sensitivity at TRPM_PZQ variants. [PDF]

Int J Parasitol Drugs Drug Resist
Rohr CM, Park SK, Aguiar-Martins K, Anderson TJC, Berger DJ, Berriman M, Buddenborg SK, Bustinduy AL, Chevalier FD, Cotton JA, Crellen T, Doyle SR, Emery AM, Kincaid Smith J, Kinung'hi S, Lamberton PHL, Le Clec'h W, Ndombi E, Pennance T, Rowel C, Summers SS, Tushabe JV, Walker M, Webster BL, Webster JP, Wilson S, Marchant JS.   +26 more
europepmc   +1 more source

Pharmacological inhibition of hydroxysteroid 11‐beta dehydrogenase type 1 (11‐βHSD1) after myocardial infarction preserves cardiac function in a translational mini‐pig model

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Plasma glucocorticoids increase acutely after MI, thereafter tissue levels are amplified selectively within cells expressing 11‐ßhydroxysteroid dehydrogenase type 1 (11‐ßHSD1) that regenerates active glucocorticoids from circulating metabolites.
Sara Al Disi, Raimondo Ascione, Shazia Khan, Thomas Johnson, Eva Sammut, Vito Domenico Bruno, Daniel Baz Lopez, Carol‐Anne James, Joanna Simpson, Natalie Z. Homer, Michael Millar, Trisha Singh, Alex von Kreigsheim, Nick L. Mills, Brian R. Walker, Ruth Andrew, Scott P. Webster, Andrew Whittaker, Adrian Freeman, Gillian A. Gray   +19 more
wiley   +1 more source