Results 231 to 240 of about 579,058 (319)

Deep learning for RNA secondary structure determination: gauging generalizability and broadening the scope of traditional methods. [PDF]

RNA
Szikszai M, Wang TY, Krueger R, Mathews DH, Ward M, Aviran S.   +5 more
europepmc   +1 more source

Fenofibrate potentiates the therapeutic efficacy of EZH2 inhibitors on melanoma via TRIM21‐ and OTUD4‐mediated EZH2 ubiquitination

British Journal of Pharmacology, EarlyView.
Background and Purpose EZH2 (enhancer of zeste homologue 2) inhibitors are an emerging class of drugs that target epigenetic regulation. However, their efficacy in solid tumours has been limited, partly due to drug‐induced upregulation of fatty acid synthesis.
Rui Cheng, Yuanjun Tang, Xuedi Cao, Xiaotong Yu, Zhanya Huang, Yunyun Guo, Renjing Jin, Yan Wang, Yang Liu, Lixiang Xue, Yuqing Wang   +10 more
wiley   +1 more source

Open Molecular Crystals 2025 (OMC25) dataset and models. [PDF]

Sci Data
Gharakhanyan V, Barroso-Luque L, Yang Y, Shuaibi M, Michel K, Levine DS, Dzamba M, Fu X, Gao M, Liu X, Ni H, Noori K, Wood BM, Uyttendaele M, Boromand A, Zitnick CL, Marom N, Ulissi ZW, Sriram A.   +18 more
europepmc   +1 more source

Second‐generation prokineticin PKR1 receptor agonists: Advancing cardioprotection against chemotherapy‐induced toxicity

British Journal of Pharmacology, EarlyView.
IS39, a novel non‐peptide PKR1 agonist, confers cardioprotection against doxorubicin‐induced toxicity. IS39 activates PKR1‐mediated pro‐survival signalling in cardiomyocytes, reducing reactive oxygen species (ROS), DNA damage and fibrosis markers. In vivo, IS39 preserves cardiac geometry and function in mice exposed to chronic doxorubicin challenge ...
Anais Audebrand, Simone Brogi, Mustafa Tezeren, Andrea Tafi, Omer H. Ocak, Hasan Koyuncu, Igor Tetko, Laurent Désaubry, Canan G. Nebigil   +8 more
wiley   +1 more source

Integrative analysis reveals SRD5A2 as a central mediator in PPCPs induced modulation of the prostate cancer immune microenvironment. [PDF]

Discov Oncol
Zhou T, Li Y, Ji P, Meng C, Liu Z, Zeng Z, Yang Y, Li T.   +7 more
europepmc   +1 more source

Global overview of progress in respecting the contributions of traditional knowledge in biodiversity governance

Conservation Biology, EarlyView.
Abstract Recognition and engagement of Indigenous Peoples and local communities (IP&LCs) and other traditional knowledge (TK) holders in formal biodiversity governance remain limited, despite their significant contribution to the conservation and sustainable use of biodiversity through their knowledge, innovations, practices, and land stewardship.
Kinga Öllerer, Pernilla Malmer, Marianna Biró, Noor Noor, Polina Shulbaeva, Maurizio Farhan Ferrari, Suneetha M. Subramanian, András Báldi, Zsolt Molnár   +8 more
wiley   +1 more source

Molecular architecture and diversity of StopGo/2A translational recoding. [PDF]

Proc Natl Acad Sci U S A
Li X, Zuber PK, Loughran G, Bhatt PR, Alquraish F, Ramakrishnan V, Firth AE, Atkins JF.   +7 more
europepmc   +1 more source

Sex‐specific differences in the prevalence of intermediate hyperglycaemia states: A systematic review and meta‐analysis

Diabetic Medicine, EarlyView.
There are sex‐specific disparities in the prevalence of different isolated intermediate hyperglycaemic states, which, in the context of clinical guidance to use FPG or HbA1c for identification, may contribute to underdiagnosis and undertreatment in primary care and introduce ascertainment bias into research and policy. Abstract Aims To evaluate the sex‐
Louise Cooper, Ian Porter, Claire Meek, Simon J. Griffin, Amy Ahern   +4 more
wiley   +1 more source

The cost of the consumer revolution: Prices, material living standards, and real inequality in Amsterdam (1630‒1805)

The Economic History Review, EarlyView.
Abstract This article measures the cost of the early modern consumer revolution through a quantitative analysis of product and process innovations in Amsterdam and examines their variegated social impact in two distinct datasets of probate inventories.
Bas Spliet, Anne E. C. McCants
wiley   +1 more source

70 years of Scottish National Accounts: 1948–2018

The Economic History Review, EarlyView.
Abstract This paper provides a comprehensive time series of historical National Accounts for Scotland (onshore and offshore) from 1948 to 2018. It includes a detailed breakdown by income component and industrial sector using methods that are forward and backward compatible.
Graeme Roy, Niall G. MacKenzie, Sandy Stewart   +2 more
wiley   +1 more source