Results 61 to 70 of about 579,058 (319)

Redetermination of cytosinium hydrogen maleate–cytosine (1/1) from the original data

Acta Crystallographica Section E: Crystallographic Communications, 2016
The title salt, C4H6N3O+·C4H3O4−·C4H5N3O, has been redetermined from the data published by Benali-Cherif, Falek & Direm [Acta Cryst. (2009), E65, o3058–o3059].
Jan Fábry
doaj   +1 more source

Testing a global city hypothesis : an assessment of polarization across US cities [PDF]

, 2012
Social polarization is perhaps most evident within the world's large cities where we can easily observe stark contrasts between wealth and poverty. A world city theoretical perspective has emerged that associates large cities importance in a global ...
Derudder, Ben, Ma, Xiulian, Sanderson, Matthew R, Timberlake, Michael, Winitzky, Jessica, Witlox, Frank   +5 more
core   +2 more sources

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Prediction of Hydrate and Solvate Formation Using Statistical Models [PDF]

, 2016
Novel, knowledge based models for the prediction of hydrate and solvate formation are introduced, which require only the molecular formula as input.
Khaled Takieddin, Krilavičius T., Liaw A., Lowry R., László Fábián, Peterson M. L., R Core Team, Randić M., Stone M., Todeschini R., Yaroslav Z. Khimyak   +10 more
core   +2 more sources

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Halide Ion Embraces in Tris(2,2′-bipyridine)metal Complexes

Crystals, 2020
An analysis of the [M(bpy)3]n+ (bpy = 2,2′-bipyridine) complexes with halide counterions in the Cambridge Structural Database reveals a common structural motif in two thirds of the compounds.
Edwin C. Constable, Catherine E. Housecroft   +1 more
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Who Watches the Watchmen? An Appraisal of Benchmarks for Multiple Sequence Alignment [PDF]

, 2012
Multiple sequence alignment (MSA) is a fundamental and ubiquitous technique in bioinformatics used to infer related residues among biological sequences. Thus alignment accuracy is crucial to a vast range of analyses, often in ways difficult to assess in ...
A Löytynoja, A Löytynoja, B Sipos, BG Hall, BG Hall, BP Blackburne, C Chothia, C Dessimoz, C Kemena, C Kemena, C Notredame, CB Do, CL Strope, DA Dalquen, DA Morrison, DH Mathews, ER Mardis, G Blackshields, G Jordan, G Landan, GP Raghava, I Walle Van, J Kim, J Stoye, JD Thompson, JD Thompson, JD Thompson, JD Thompson, JD Thompson, JD Thompson, JH Havgaard, JP Huelsenbeck, K Mizuguchi, LA Stebbings, M Anisimova, M Pop, MR Aniba, P Gardner, RA Cartwright, RB Russell, RC Edgar, RC Edgar, SA Berger, SF Altschul, T Golubchik, T Koestler, T Lassmann, T Lassmann, T Lassmann, W Fletcher   +49 more
core   +2 more sources

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Details Matter in Structure-based Drug Design

CHIMIA, 2023
Successful structure-based drug design (SBDD) requires the optimization of interactions with the target protein and the minimization of ligand strain. Both factors are often modulated by small changes in the chemical structure which can lead to profound
Bernd Kuhn, Jens-Uwe Peters, Markus G. Rudolph, Peter Mohr, Martin Stahl, Andreas Tosstorff   +5 more
doaj   +1 more source