Results 251 to 260 of about 1,484,707 (375)
Hijacking the Host Clock: A Nematode Effector Antagonizes Soybean Circadian Defense and Translation Control
Advanced Science, EarlyView.Soybean employs its circadian clock, governed by GmCCA1, to rhythmically defend against soybean cyst nematodes. The pathogen retaliates by secreting the effector Hg4E02, which hijacks the clock to suppress defense and co‐opt the host's translation machinery for nutrient acquisition.Xingwei Wang, Yufeng Xu, Yanfei Hu, Lijun Cao, Ru Jiang, Changtian Chen, Rick Masonbrink, Thomas Maier, Yuchen Tu, Yabo Shi, Enhui Liu, Lingan Kong, Chan Guo, Wei Zhao, Peng Shi, Wenzhen Du, Andrew Severin, Thomas Baum, Deliang Peng, Huan Peng, Mian Zhou, Wei Wang +21 morewiley +1 more sourceLarge-scale and long-term wildlife research and monitoring using camera traps: a continental synthesis. [PDF]
Biol Rev Camb Philos SocBruce T, Amir Z, Allen BL, Alting BF, Amos M, Augusteyn J, Ballard GA, Behrendorff LM, Bell K, Bengsen AJ, Bennett A, Benshemesh JS, Bentley J, Blackmore CJ, Boscarino-Gaetano R, Bourke LA, Brewster R, Brook BW, Broughton C, Buettel JC, Carter A, Chiu-Werner A, Claridge AW, Comer S, Comte S, Connolly RM, Cowan MA, Cross SL, Cunningham CX, Dalziell AH, Davies HF, Davis J, Dawson SJ, Di Stefano J, Dickman CR, Dillon ML, Doherty TS, Driessen MM, Driscoll DA, Dundas SJ, Eichholtzer AC, Elliott TF, Elsworth P, Fancourt BA, Fardell LL, Faris J, Fawcett A, Fisher DO, Fleming PJS, Forsyth DM, Garza-Garcia AD, Geary WL, Gillespie G, Giumelli PJ, Gracanin A, Grantham HS, Greenville AC, Griffiths SR, Groffen H, Hamilton DG, Harriott L, Hayward MW, Heard G, Heiniger J, Helgen KM, Henderson TJ, Hernandez-Santin L, Herrera C, Hirsch BT, Hohnen R, Hollings TA, Hoskin CJ, Hradsky BA, Humphrey JE, Jennings PR, Jones ME, Jordan NR, Kelly CL, Kennedy MS, Knipler ML, Kreplins TL, L'Herpiniere KL, Laurance WF, Lavery TH, Le Pla M, Leahy L, Leedman A, Legge S, Leitão AV, Letnic M, Liddell MJ, Lieb ZE, Linley GD, Lisle AT, Lohr CA, Maitz N, Marshall KD, Mason RT, Matheus-Holland DF, McComb LB, McDonald PJ, McGregor H, McKnight DT, Meek PD, Menon V, Michael DR, Mills CH, Miritis V, Moore HA, Morgan HR, Murphy BP, Murray AJ, Natusch DJD, Neilly H, Nevill P, Newman P, Newsome TM, Nimmo DG, Nordberg EJ, O'Dwyer TW, O'Neill S, Old JM, Oxenham K, Pauza MD, Pestell AJL, Pitcher BJ, Pocknee CA, Possingham HP, Raiter KG, Rand JS, Rees MW, Rendall AR, Renwick J, Reside A, Rew-Duffy M, Ritchie EG, Roach CP, Robley A, Rog SM, Rout TM, Schlacher TA, Scomparin CR, Sitters H, Smith DA, Somaweera R, Spencer EE, Spindler RE, Stobo-Wilson AM, Stokeld D, Streeting LM, Sutherland DR, Taggart PL, Teixeira D, Thompson GG, Thompson SA, Thorpe MO, Todd SJ, Towerton AL, Vernes K, Waller G, Wardle GM, Watchorn DJ, Watson AWT, Welbergen JA, Weston MA, Wijas BJ, Williams SE, Woodford LP, Wooster EIF, Znidersic E, Luskin MS. +170 moreeuropepmc +1 more sourceEndoplasmic Reticulum Geometry Dictates Neuronal Bursting via Calcium Store Refill Rates and Exposes Selective Neuronal Vulnerability
Advanced Science, EarlyView.The ER's continuous tubular network is maintained by ER‐shaping proteins whose mutation or dysregulation contributes to neurodegenerative diseases. Here, we show that ER morphology sets the speed of Ca2+ store replenishment between firing events. Disrupting ER continuity slows intra‐ER Ca2+ redistribution from extracellular refill (SOCE) sites, driving Valentina Davi, Pierre Parutto, Yuyi Zhang, Tasuku Konno, Cecile Crapart, Raquel Pereira, John P. Franklin, Mosab Ali Awadelkareem, Daniel C Maddison, Michael J. Devine, Edgar R. Gomes, Joseph Chambers, Elena Koslover, Edward Avezov +13 morewiley +1 more sourceVorinostat Potentiates Chemoimmunotherapy in Immune‐Enriched Pancreatic Cancer
Advanced Science, EarlyView.Immune‐enriched pancreatic cancer does not confer a significant survival advantage. SAHA sensitizes these “hot” tumors to chemoimmunotherapy by disrupting a FASN/PARP9‐driven “metabolic trap” and enhancing CD8+ T cell function. A CD8high/FASNhigh/PARP9high signature identifies patients who are most likely to benefit from the “gemcitabine‐nivolumab‐SAHA”Chen Chen, Dingru Li, Yingna Liao, Zehua Wang, Chunbin Zhu, Zifeng Zhang, Liquan Jin, Yueyue Chen, Jiaoshun Chen, Junyi Xu, Miaoyan Wei, Rong Tang, Xianjun Yu, Si Shi +13 morewiley +1 more source