Results 51 to 60 of about 713,161 (302)

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Density of fishers and the efficacy of relative abundance indices and small‐scale occupancy estimation to detect a population decline on the Hoopa Valley Indian Reservation, California

Wildlife Society Bulletin, 2011
We used a mark–resight design to calculate density estimates of fisher (Martes pennanti), a candidate for listing under the United States Endangered Species Act, on the Hoopa Valley Indian Reservation in northwestern California, USA in order to determine
Sean M. Matthews, J. Mark Higley, J. Scott Yaeger, Todd K. Fuller   +3 more
doaj   +1 more source

Systems Engineering Baseline Concept of a Multispectral Drone Detection Solution for Airports

IEEE Access, 2017
The baseline concept for a multispectral drone detection (MSDD) system for use in airports is generated. The baseline development process is based on a modified system of systems architecting with ilities (SAI) method.
Rick L. Sturdivant, Edwin K. P. Chong
doaj   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

A High-Speed, Multi-Channel Lossless Compression Algorithm for High-Resolution Video on FPGA

IEEE Access
With the increasing image resolution, data bit depth, and frame rate of industrial cameras, the signal output speed needs to be improved to keep pace with the rapidly developing image sensor technologies.
Xingkai Du, Longhua Xie, Hongchuan Huang, Huawei Chen, Xiaolong Guo, Tingyu Zhao   +5 more
doaj   +1 more source

Spherical Robots for Special Purposes: A Review on Current Possibilities

Sensors, 2022
The review discusses the possibilities of different driving mechanisms and sensors of spherical robots, and a special kind of mobile robots is introduced and discussed.
Marek Bujňák, Rastislav Pirník, Karol Rástočný, Aleš Janota, Dušan Nemec, Pavol Kuchár, Tomáš Tichý, Zbigniew Łukasik   +7 more
doaj   +1 more source

General Dynamic Scene Reconstruction from Multiple View Video [PDF]

, 2015
This paper introduces a general approach to dynamic scene reconstruction from multiple moving cameras without prior knowledge or limiting constraints on the scene structure, appearance, or illumination.
Guillemaut, Jean-Yves, Hilton, Adrian, Kim, Hansung, Mustafa, Armin   +3 more
core   +2 more sources

Anchorage‐independent and faster growth in clonal population from UV‐irradiated NER‐deficient cells

FEBS Open Bio, EarlyView.
UV‐irradiated cells expressing a DDB2 mutant protein unable to interact with PCNA (DDB2PCNA‐) form clones able to grow without anchorage. Different experimental approaches reveal heterogeneity in cell cycle regulation and drug response within these clones, emphasizing the crucial role of the DDB2‐PCNA interaction in preventing cellular transformation ...
Paola Perucca, Anna Tricarico, Martina Furfaro, Priyam Ghosh, Ennio Prosperi, Lucia Anna Stivala, Ornella Cazzalini   +6 more
wiley   +1 more source

IoT climate resilience in Central Asia: understanding perceived risks through a user survey analysis applied to Kazakhstan

Frontiers in Sustainable Cities
Climate change poses significant risks to the resilience of Internet of Things (IoT) infrastructure, especially in regions with extreme and variable climates such as Central Asia.
Dinara Zhunissova, David Topping, James Evans   +2 more
doaj   +1 more source