Results 231 to 240 of about 51,149 (268)

Empagliflozin Improves Cardiomyocyte Function in Phospholamban-R14del Cardiomyopathy by Regulating Calcium/Calmodulin-Stimulated Protein Kinase II Activity and Apoptosis. [PDF]

J Am Heart Assoc
Hnatiuk AP, Li AW, Vecci BE, Staudt DW, Serrano R, Gao X, Tran PPQ, Mercola M.   +7 more
europepmc   +1 more source

Synaptic memory and CaMKII

Physiological Reviews, 2023
Ca2+/calmodulin-dependent protein kinase II (CaMKII) and long-term potentiation (LTP) were discovered within a decade of each other and have been inextricably intertwined ever since. However, like many marriages, it has had its up and downs. Based on the unique biochemical properties of CaMKII, it was proposed as a memory molecule before any ...
Roger A Nicoll, Howard Schulman
exaly   +3 more sources

Physiological and unappreciated roles of CaMKII in the heart [PDF]

Basic Research in Cardiology, 2018
In the cardiomyocyte, CaMKII has been identified as a nodal influencer of excitation-contraction and also excitation-transcription coupling. Its activity can be regulated in response to changes in intracellular calcium content as well as after several post-translational modifications.
Maarten M G Van Den Hoogenhof, Johannes Backs   +1 more
exaly   +4 more sources

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CaMKII as a target for arrhythmia suppression

Pharmacology & Therapeutics, 2017
Calcium/calmodulin-dependent protein kinase II (CaMKII) has emerged as key enzyme in many cardiac pathologies, especially heart failure (HF), myocardial infarction and cardiomyopathies, thus leading to contractile dysfunction and malignant arrhythmias.
Julian, Mustroph, Stefan, Neef, Lars S, Maier   +2 more
openaire   +2 more sources

Binding of CaMKII to the giant muscle protein projectin: stimulation of CaMKII activity by projectin

Biochimica et Biophysica Acta (BBA) - General Subjects, 2002
Projectin is an integral high molecular mass protein of insect flight muscle binding to myosin and paramyosin. Yet, the role of projectin in insect flight muscle is not well understood. In this study we provide evidence for the interaction of projectin with the calcium sensor Ca(2+)/calmodulin-dependent protein kinase II (CaMKII).
Michael, Fährmann, Martin, Erfmann, Gernot, Beinbrech   +2 more
openaire   +2 more sources

Analysis of pThr286-CaMKII and CaMKII immunohistochemistry in the hippocampus of patients with temporal lobe epilepsy

Epilepsy Research, 2005
Ca2+/calmodulin-dependent protein kinase II (CaMKII) phosphorylates a variety of neuronal proteins, thereby, coordinating responses to changes of intracellular Ca2+ concentrations. Autophosphorylation at threonine286 generates an autonomously active form of CaMKII (pThr286-CaMKII), thus prolonging responses to transient increases in Ca2+.
Ailing A, Lie, Britta, Sommersberg, Christian E, Elger   +2 more
openaire   +2 more sources

Characterization of a selective CaMKII peptide inhibitor

European Journal of Medicinal Chemistry, 2013
Analogs of potent CaMKinase II inhibitor, CaM-KNtide, were prepared to explore new structural requirements for the inhibitory activity. The full potency of CaMKII inhibition by CaM-KIINα is contained within a minimal region of 19 amino acids. Here, analysis of the homologous CaM-KIINβ showed that a 17 mer peptide (CN17β) was the shortest sequence that ...
GOMEZ MONTERREY, ISABEL MARIA, Sala M., Rusciano M. R., Monaco S., Maione A. S., Iaccarino G., Tortorella P., D'Ursi A. M., Scrima M., CAROTENUTO, ALFONSO, DE ROSA, GIUSEPPE, Bertamino A., Vernieri E., GRIECO, PAOLO, NOVELLINO, ETTORE, ILLARIO, MADDALENA, Campiglia P.   +16 more
openaire   +4 more sources

Sequestration of CaMKII in dendritic spines in silico

Journal of Computational Neuroscience, 2011
Calcium calmodulin dependent kinase II (CaMKII) is sequestered in dendritic spines within seconds upon synaptic stimulation. The program Smoldyn was used to develop scenarios of single molecule CaMKII diffusion and binding in virtual dendritic spines. We first validated simulation of diffusion as a function of spine morphology.
Shahid Khan 0005, Yixiao Zou, Asma Amjad, Ailia Gardezi, Carolyn L. Smith, Christine Winters, Thomas S. Reese   +6 more
openaire   +2 more sources

Camguk Regulation of CaMKII

Science's STKE, 2004
Lu et al. investigated the interaction of calcium/calmodulin-dependent protein kinase II (CaMKII) with Camguk (Cmg), a Drosophila membrane-associated guanylate kinase, and discovered that Cmg participated not only in CaMKII localization but also in regulating its sensitivity to calcium-CaM ...
openaire   +1 more source

Aβ impairs the LTP-related movement of endogenous CaMKII but not of exogenous GFP-CaMKII

Molecular Biology of the Cell
Amyloid β (Aβ) inhibits hippocampal long-term potentiation (LTP; a form of synaptic plasticity thought to underly learning and memory) by inhibiting the stimulation-induced synaptic accumulation of the Ca2+/calmodulin (CaM)-dependent protein kinase II (CaMKII).
Carolyn Nicole, Brown, Fan-Yi, Chao, Daphne, Quang, Nicole L, Rumian, Mason S, Kleinjan, Steven J, Coultrap, K Ulrich, Bayer   +6 more
openaire   +2 more sources