Results 121 to 130 of about 1,724,681 (307)
Ronald Reagan, Jesse Unruh and the California Gubernatorial Race, 1970 [PDF]
, 2018 This essay examines the 1970 gubernatorial race in California between incumbent Ronald Reagan and powerful California legislator Jesse Unruh. Most of the scholarship on this particular subject tends to revolve around Reagan\u27s first campaign for ...
Alvarado, Alice L
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Cortical Somatostatin Neurons Regulate Seizure Susceptibility via MINAR1/Gαs–cAMP Signaling
Advanced Science, EarlyView.Our study identifies MINAR1 as a novel regulator of cortical interneuron excitability and seizure susceptibility. MINAR1 is preferentially expressed in SST+ interneurons. Genetic ablation of MINAR1 leads to seizure hypersensitivity, reduced SST+ neuron excitability, and impaired Gαs–cAMP signaling, disrupting the E/I balance.
Wei‐Tang Liu +20 more
wiley +1 more source
Calcium-independent contraction in lysed cell models of teleost retinal cones: activation by unregulated myosin light chain kinase or high magnesium and loss of cAMP inhibition. [PDF]
, 1987 The retinal cones of teleost fish contract at dawn and elongate at dusk. We have previously reported that we can selectively induce detergent-lysed models of cones to undergo either reactivated contraction or reactivated elongation, with rates and ...
Ackland, N, Burnside, B
core
Advanced Science, EarlyView.Impaired endometrial receptivity contributes to the poor pregnancy outcomes in women with PCOS. The authors found that decreased endometrial IL‐22 levels and disrupted STAT3‐IGFBP5 signaling pathway contributed to impaired endometrial receptivity. Supplementation with IL‐22 or IGFBP5 exerts a protective effect on implantation failure in PCOS‐like mice,
Baoying Liao +13 more
wiley +1 more source
Syn-ThèsesTransgressing the boundaries of fiction and the real world, satire opens a dialogue between the aesthetic and political stakes of a work of art. A comparative analysis of “Springtime for Hitler” and “If You Could See Her”, comic songs from the 20th ...
Maya Mehr Haidar
doaj +1 more source
A predictive computational model reveals that GIV/girdin serves as a tunable valve for EGFR-stimulated cyclic AMP signals. [PDF]
, 2019 Cellular levels of the versatile second messenger cyclic (c)AMP are regulated by the antagonistic actions of the canonical G protein → adenylyl cyclase pathway that is initiated by G-protein-coupled receptors (GPCRs) and attenuated by phosphodiesterases (
Getz, Michael +4 more
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Systematically Engineering for Efficient Production of 3‐Methyl‐1‐Butanol in Escherichia coli
Advanced Science, EarlyView.An integrated metabolic engineering strategy was established for high‐level 3‐methyl‐1‐butanol biosynthesis in Escherichia coli. Molecular dynamics‐guided semi‐rational engineering of dihydroxyacid dehydratase uncovered and relieved key catalytic bottlenecks, while adaptive laboratory evolution enhanced strain robustness.
Nanfei Geng +6 more
wiley +1 more source
Advanced Science, EarlyView.Paraventricular CRF neurons in the hypothalamus project to glutamatergic neurons of the spinal trigeminal caudal nucleus, enhancing neuronal activation and CRFR2 signaling. This pathway increases CRF release and excitatory drive, promoting central sensitization and migraine‐related behaviors. Targeting the PVN–SP5C circuit provides a potential strategy
Jiang Bian +13 more
wiley +1 more source
Scientific ReportsWe demonstrate the feasibility of machine-learning aided UV absorbance spectroscopy for in-process microbial contamination detection during cell therapy product (CTP) manufacturing.
Shruthi Pandi Chelvam +8 more
doaj +1 more source
Microbial CellWe recently characterized the competitive inhibition of cyclic AMP (cAMP) on three periplasmic acid phosphatases, AphAHi, NadNHi, and eP4 (HelHi), in Haemophilus influenzae Rd KW20. This inhibitory effect is vital for orchestrating the nutritional growth
Kristina Kronborg, Yong Everett Zhang
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