Ruxolitinib pharmacokinetics (PK) has been characterized in clinical trials but remains poorly documented in real‐world practice. This project aimed to investigate ruxolitinib PK in routine clinical practice, identify factors driving its variability, and explore exposure–response relationships to assess the potential role of therapeutic drug monitoring.
Jérémie Tachet +11 more
wiley +1 more source
Increasing Respiration Weakens the Carbon Sink Over Two Decades in a Temperate Deciduous Forest
Using a 20‐year eddy covariance record from a temperate deciduous forest, we show that net carbon uptake declined over two decades. Both the trend and interannual variability in net carbon exchange were respiration driven, with warming winters and increasing late‐summer diffuse light driving the trend in respiration.
Darby D. Bergl +8 more
wiley +1 more source
Pseudonyms, Propaganda, and Prints: The Life and Political Caricatures of William Dent, 1782–931
Abstract ‘Dent was probably an amateur and nothing is known of his life’, state Bryant and Heneage. Despite contributing to caricature's ‘golden age’, William Dent remains overlooked compared to contemporaries like James Gillray. Dent's extensive portfolio (1782–93) and rumoured role as a Pittite propagandist have not secured his place in the canon of ...
Callum D. Smith
wiley +1 more source
After the Hype: Resilience Seeking in Emerging Technology Ecosystems
ABSTRACT Academic Summary Hype often helps emerging technology ecosystems gain early support for their innovative value propositions, but the initial excitement around the technology typically vanishes at some point. This decrease in excitement and support may lead some ecosystems to fail while others are resilient and recover.
Fiona Schweitzer +2 more
wiley +1 more source
Developing a macroecology for human‐altered ecosystems
Although anthropogenically‐induced ecological disruptions are fundamentally important in defining ecosystem properties, they are largely overlooked by macroecological theory. Anthropogenic disruptions and their effects are generally not comparable to one another, nor to disturbances that are part of natural disturbance regimes.
Erica A. Newman +7 more
wiley +1 more source
From community care to corporate category: Platforms' discourse on digital trans‐affirming practices
Abstract Trans‐affirming community movements have interfaced with tech platforms in recent decades, leading to innovations in pronoun‐sharing online. As (mostly US‐based) platforms created online “pronouns fields,” they released supportive statements and help pages about the feature. However, with the recent roll‐back of LGBTQ+ support, such support is
Cedar Brown
wiley +1 more source
Welcome back Kotter-Developing a National Allergy strategy for Australia. [PDF]
Vale SL +4 more
europepmc +1 more source
GIPR/GLP-1R dual agonist therapies for diabetes and weight loss-chemistry, physiology, and clinical applications. [PDF]
Campbell JE +5 more
europepmc +1 more source
Big food and drink sponsorship of conferences and speakers: a case study of one multinational company's influence over knowledge dissemination and professional engagement. [PDF]
Atli Gunnarsson J +3 more
europepmc +1 more source

