Results 201 to 210 of about 824,161 (234)

Thinking Outside the Binding Site: A Self‐Encapsulating Kinase Inhibitor Remodels Its Pocket to Achieve Selectivity

Angewandte Chemie International Edition, EarlyView.
To make exceptionally effective drugs, thinking “outside the binding site” is required. This work reveals that counterintuitive targeting of a kinase‐conserved region can lead to highly selective binding. Inhibitor discovery coupled to x‐ray crystallography shows that a network of noncanonical interactions and long‐range effects of distant unique amino
Nico J. Seidler, Monica R. MacDonald, Athina A. Moschopoulou, Sahba Cunningham, Tess M. Weber, Nader N. Nasief, Lorenz Mayer, Frederik W. Hacker, Ekaterina Hermann, Mareike B. Möllers, Yuliia Skliarenko, Tahereh Damghani, Abid N. Manzar, Kaly S. Lin, Ramona Rudalska, Marcia I. Goettert, Lars Zender, Daniel Dauch, Michael Forster, Stefan A. Laufer, David E. Heppner   +20 more
wiley   +1 more source

Evaluating the implementation of the 'Patient Safety Caravan' for patient engagement in Riyadh, Saudi Arabia. [PDF]

BMC Health Serv Res
AlKhalil R, Aldalbahi F, Al-Wathnani A, Majrashi M, Alshabib T, AlFayyad I.   +5 more
europepmc   +1 more source

A framework policy analysis of single-dose HPV vaccination adoption in East Africa: a rapid review. [PDF]

BMC Health Serv Res
Umutesi G, Weiner BJ, Jewell T, Kapiga S, Lane J, Mugo NR, Barnabas RV.   +6 more
europepmc   +1 more source

Adding employment status in the medical record demonstrates its importance as a social determinant of health. [PDF]

JAMIA Open
Breeher LE, Westphal S, Green T, Abbas A, Cowl CT.   +4 more
europepmc   +1 more source

Profiling zero-dose measles-rubella children in Zambia: Insights from the 2024 post-campaign coverage survey. [PDF]

PLOS Glob Public Health
Mwale M, Phiri G, Mwansa FD, Chipimo PJ, Masumbu P, Matanda K, Kayeye P, Mwangilwa K, Nakazwe C, Namukoko H, Mutembo S, Masaninga F, Sakala J, Lugala PC.   +13 more
europepmc   +1 more source

Community engagement approaches and influencing factors in Aedes mosquito management: a case study from North Queensland, Australia. [PDF]

BMC Public Health
Allen T, Crouch A, Russell TL, Topp SM.
europepmc   +1 more source

Synthesis of Aminocyclopropanes by Redox‐Neutral Aminoalkylation

Angewandte Chemie International Edition, EarlyView.
Aminocyclopropane synthesis by hydroaminoalkylation utilizing cheap, readily available starting materials is presented, offering orthogonality to commonly used methods and allowing broad functional‐group tolerance. Solvent‐mediated conditions enable the reaction of a pre‐formed hemiaminal with alkenes and alkynes.
Gwyndaf A. Oliver, Konstantin Günther, Chiara Sebastianelli‐Schoditsch, Sophie Woolford, Iina Ludwig, Harald H. Sitte, Nuno Maulide   +6 more
wiley   +1 more source

Health Communication Campaign Performance During the HEALing Communities Study: Cross-Sectional Examination of Digital Advertising Methods. [PDF]

J Med Internet Res
Lewis N, Reynolds J, Krause D, Reeves PM, Luster J, Stein MD, Walsh SL, Farmer A, Lofwall MR, Roberts MF, Surratt HL, Crockett BN, Stephens K, Bursey K, Mattson K, Slater MD.   +15 more
europepmc   +1 more source

Good Arts, Good Mental Health^®: the effectiveness of an Australian health promotion media campaign in promoting community mental wellbeing via the arts. [PDF]

Front Public Health
Davies CR, Pescud MT, Clifford R, McGrath R, Thomson A, Jeffrey M, Stoneham M, Pikora T, Wright P, Girdler S, Baldassar L, Clift S.   +11 more
europepmc   +1 more source