Results 141 to 150 of about 276,254 (364)

Esketamine/Ketamine: Dual‐Action Mechanisms and Clinical Prospects beyond Anesthesia in Psychiatry, Immunology, and Oncology

open access: yesAdvanced Science, EarlyView.
Esketamine and ketamine are widely used for perioperative analgesia and anesthesia. Despite their established roles in analgesia, sedation, and anesthesia, as well as emerging antidepressant, anti‐tumor, and anti‐inflammatory effects, their clinical use is limited due to side effects and addiction potential.
Yinxin Wang   +7 more
wiley   +1 more source

An investigation into the concept of and factors leading to impact creep and its management [PDF]

open access: yes, 2006
This study defines and explores the nature of impact creep within the context of two contrasting case studies. The methods applied in undertaking this study consisted of a literature review and development and distribution of questionnaires to visitors ...
Newsome, D., Smith, A.J.
core   +1 more source

F‐Box and Leucine‐Rich Repeat Protein 4 (FBXL4) Maintains Sarcomere Integrity and Cardiac Function by Enhancing K48‐Linked Ubiquitinated Degradation of Profilin‐1 (PFN1)

open access: yesAdvanced Science, EarlyView.
Schematic diagram depicting the proposed signaling mechanisms underlying the effects of FBXL4 in the setting of cardiac hypertrophy. Under hypertrophic stimulation, cardiomyocytes‐specific overexpression FBXL4 maintains sarcomere integrity and cardiac function by enhancing K48‐linked ubiquitinated degradation of PFN1 at the K70 site.
Xingda Li   +11 more
wiley   +1 more source

Tourist Carrying Capacity for Sustainable Development of Gunung Gede Pangrango National Park Ecotourism

open access: yesTourism and Hospitality
This study presents a comprehensive carrying capacity assessment for Gunung Gede Pangrango National Park (GGPNP), a key biodiversity hotspot in Java, Indonesia, integrating Physical Carrying Capacity (PCC), Real Carrying Capacity (RCC), and social ...
Sebastien M. R. Dente   +3 more
doaj   +1 more source

DIFFICULTIES IN ENGLISH TEACHING-LEARNING ACTIVITY FOR 8th GRADE JUNIOR HIGH SCHOOL IN SMP NEGERI 4 KARANGANOM, KLATEN [PDF]

open access: yes, 2011
AULIA FILIQ ASMARANI, 2011, DIFFICULTIES IN ENGLISH TEACHING-LEARNING ACTIVITY FOR 8th GRADE JUNIOR HIGH SCHOOL IN SMP NEGERI 4 KARANGANOM, English Diploma Program, Faculty of Letters and Fine Arts, Sebelas Maret University.
Filiq Asmarani, Aulia
core  

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

open access: yesAdvanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu   +11 more
wiley   +1 more source

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