Results 151 to 160 of about 276,254 (364)

A Simplified Three‐Tailed N‐Alkyl Phosphoramidate Lipid Platform Enables Inguinal Adipose‐Accumulated mRNA Delivery for Anti‐Obesity Therapy

Advanced Science, EarlyView.
This study develops an mRNA therapy encoding a long‐acting GLP‐1/FGF21 fusion protein. A three‐tailed ionizable lipid engineered three‐component lipid nanoparticle delivers the mRNA to inguinal adipose tissue. In obese mice, this targeted, dual‐hormone treatment potently reduces body weight, fat mass, presenting a localized strategy for metabolic ...
Bin Ma, Yunxuan Liu, Huijuan Zhang, Yian Fang, Yizhe Xue, Junsheng Xue, Ziqiong Jiang, Tianyan Zhou, Yanyun Hao, Fei Xie, Lei Miao   +10 more
wiley   +1 more source

ATP-citrate lyase. Structure of a tryptic peptide containing the phosphorylation site directed by glucagon and the cAMP-dependent protein kinase.

, 1981
Mark Pierce, J L Palmer, Henry T. Keutmann, Joseph Avruch   +3 more
openalex   +1 more source

Massive ovarian cystic teratomas diagnosed at a rural Nepal camp [PDF]

, 2012
Alan L. Williams
openalex   +1 more source

Naked‐Eye Visual Warning of ppmv‐Level Fault‐Free Humidity Upper Limit

Advanced Science, EarlyView.
In this study, based on the urgent need in many critical fields for ppmv‐level fault‐free humidity upper limit (ppmv‐FFHUL) monitoring, an innovative threshold gated humidity sensing technology was developed. It exhibits superior portability (as thin and light as paper) and highly economic feature (without auxiliary instruments at all), and can achieve
Xiaoyan Wei, Tianyou Qin, Siyu Wang, Sean Xiao‐An Zhang, Lan Sheng   +4 more
wiley   +1 more source

Potential Improvements to National Park Service Visitor Surveys and Money Generation Modeling in Alaska [PDF]

, 2013
This study presents options for improving the use of the Money Generation Model in National Park Service (NPS) land units in Alaska. The Money Generation Model (MGM) is used nationwide to model economic impacts of visitation to public lands, including ...
Colt, Steve, Fay, Ginny, Hanna, Virgene
core  

A Biomimetic Norepinephrine‐Loaded Aligned Mineralized Collagen Scaffold for Coordinated Neurovascular, Osteogenic, and Immunomodulatory Repair of Critical‐Sized Bone Defects

Advanced Science, EarlyView.
Inspired by the composition and structure of native bone tissue and its complex interplay of biological signals, a norepinephrine‐loaded biomimetic mineralized electrocompacted collagen scaffold (NE‐MEC) is developed capable of simultaneously supporting osteogenesis, neural repair, angiogenesis, and immune modulation.
Zhengyun Ren, Zhaojun Wu, Anhang Wu, Hui Zhang, Jiachen Lu, Jiahao Zhang, Jie Weng, Jinhua Zhang, Song Chen, Huan Tan, Tailin Guo   +10 more
wiley   +1 more source

Influencing factors of tourist loyalty in China camping destinations based on Expectation Confirmation Theory: the mediating role of satisfaction and well-being

Humanities & Social Sciences Communications
This study explores the influence of relaxation, novelty seeking, and destination image on the satisfaction and well-being of camping tourists, and how these factors contribute to tourist loyalty within the framework of Expectation Confirmation Theory ...
Cao Chaoyi, Liu Huijuan, Wang Zhenbin
doaj   +1 more source

Camp Concern [PDF]

Public Health Reports (1896-1970), 1969
J, Gordon, J, Redfern, J W, Smith
openaire   +2 more sources

Reviewer #3 (Public Review): A simple mechanism for integration of quorum sensing and cAMP signalling in V. cholerae

, 2023

openalex   +1 more source

Traceless Regulation of Genetic Circuitry

Advanced Science, EarlyView.
Energy‐based, as opposed to molecular, control offers unprecedented improvements in key circuit parameters. This review summarizes the fundamentals of such traceless switches, categorizes them by trigger modalities, and compares and contrasts distinct advantages as well as shortcomings of each kind.
Gokberk Unal, Martin Fussenegger
wiley   +1 more source