Results 181 to 190 of about 201,283 (312)

Inosine‐Triphosphate‐Pyrophosphatase Activity as a Potential Predictor of Methotrexate Remission in Juvenile Idiopathic Arthritis

Arthritis &Rheumatology, EarlyView.
Objective Methotrexate (MTX) is the first‐line therapy for juvenile idiopathic arthritis (JIA), but up to 40% of patients do not respond to it. Low inosine triphosphate pyrophosphatase (ITPA) activity has been associated with reduced clinical remission. We investigated the role and underlying mechanisms of ITPA in vitro. Methods ITPA enzymatic activity
Sofia Sindici Forgiarini, Marianna Lucafò, Debora Curci, Davide Selvestrel, Valentina Moressa, Sofia Pagarin, Barbara Bellich, Martina Franzin, Alberto Tommasini, Mara L. Becker, Laura B. Ramsey, Susan D. Thompson, Carl D. Langefeld, Federica Corba, Edoardo Marrani, Gabriele Simonini, Gabriele Stocco, Giuliana Decorti, Andrea Taddio, Serena Pastore   +19 more
wiley   +1 more source

Impact of habitat associations on saproxylic beetle assemblages and their damage severity. [PDF]

Sci Rep
Batchudur BA, Tsagaantsooj N, Ganbat D, Boldgiv B.   +3 more
europepmc   +1 more source

CD14 Plays a Critical Role in Pain and Inflammation Across Multiple Models of Post‐traumatic Osteoarthritis

Arthritis &Rheumatology, EarlyView.
Objective We employed global genetic deletion of CD14 and intra‐articular CD14 blockade across multiple murine osteoarthritis (OA) models that vary in severity of pathology and rate of progression to test the hypothesis that CD14 inhibition attenuates synovial inflammation and associated pain during disease progression.
Kevin G. Burt, Sanique M. South, Natalie S. Adamczyk, Vu Nguyen, Shingo Ishihara, Cheng Zhou, Kate L. Sharp, Sung Y. Kim, Anna E. Rapp, Baofeng Hu, Lance A. Murphy, Li‐Yin Hung, De'Broski Herbert, Joshua F. Baker, Robert L. Mauck, Timothy M. Griffin, Anne‐Marie Malfait, Rachel E. Miller, Carla R. Scanzello   +18 more
wiley   +1 more source

Effect of hyperbaric oxygen therapy on early features of carbon monoxide poisoning focusing on neurological symptoms. [PDF]

Int J Emerg Med
Shin S, Woo J.
europepmc   +1 more source

Arthroscopic Lateral Collateral Ligament Reconstruction With Tendon Graft in High‐Grade Atraumatic Posterolateral Rotatory Instability in Elbows

Arthroscopy Techniques, EarlyView.
Abstract Lateral collateral ligament imbrication has been reported to yield good results in patients with atraumatic posterolateral rotatory instability who do not respond to conservative treatment. In cases of high‐grade instability, however, achieving adequate ligament tension can be difficult, and excessive tightening often contributes to ...
Cholawish Chanlalit, Chidchanok Sakdapanichkul, Nattakorn Mahasupachai   +2 more
wiley   +1 more source

Snow droughts, deluge, and reservation systems interact to drive recreation access at Yosemite National Park. [PDF]

Sci Rep
Jenkins JS, Marshall AM, Shiflett SA, Mattos RF, Sanchez IT, Athearn ND.   +5 more
europepmc   +1 more source

Colaizzi’s descriptive phenomenological method [PDF]

, 2015
King, Nigel, Morrow, Rosie, Rodriguez, Alison   +2 more
core  

The Role of Microbiota Metabolites Propionic Acid, p‐Cresol, and 4‐Ethylphenyl Sulfate in Autism Susceptibility: A Systematic Review

Autism Research, EarlyView.
ABSTRACT The etiopathogenesis of Autism Spectrum Disorder (ASD) encompasses complex interactions between genetic and environmental risk factors. The high prevalence of gastrointestinal disorders in autistic individuals has propelled a growing interest in the possible involvement of gut dysbiosis in ASD pathogenesis.
Laura Sandoni, Lisa Asta, Nicole Giompaolo, Rinvil Renaldi, Alberto Amaretti, Maddalena Rossi, Antonio M. Persico   +6 more
wiley   +1 more source

Distal phalanx of the hand's digit as unusual autologous biological tissue acting as a contaminating foreign body in a combat patient with ballistic pelvic injury: a case report from war in Ukraine. [PDF]

Int J Emerg Med
Lurin I, Khoroshun E, Nehoduiko V, Shypilov S, Gorobeiko M, Dinets A.   +5 more
europepmc   +1 more source

Pentoxifylline dose finding trial in preterm neonates with suspected late onset sepsis (PTX‐trial)

British Journal of Clinical Pharmacology, EarlyView.
Aim The aim of this study (PTX‐trial) is to determine the optimal dose of pentoxifylline (PTX) in preterm neonates (gestational age < 30 weeks) with (suspected) late onset sepsis (LONS). Methods The PTX‐trial is a prospective multicentre open‐label sequential dose‐optimization study with an adapted continual reassessment method.
Serife Kurul, H. Rob Taal, Jan Mazela, Ryszard Lauterbach, Irwin K. M. Reiss, Karel Allegaert, Robert B. Flint, Sinno H. P. Simons   +7 more
wiley   +1 more source