Results 201 to 210 of about 77,374,412 (333)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

The virus lesson: Teaching viral structure and quasi-symmetry in mixed reality. [PDF]

Protein Sci
Gardner A, Cannac F, Tallon Q, Olson A, Autin L.   +4 more
europepmc   +1 more source

A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD.

Neuron, 2011
A. Renton, E. Majounie, A. Waite, J. Simón-Sánchez, S. Rollinson, J. R. Gibbs, Jennifer Schymick, Hannu Laaksovirta, J. Swieten, L. Myllykangas, H. Kalimo, A. Paetau, Yevgeniya A. Abramzon, A. Remes, Alice Kaganovich, Sonja W. Scholz, J. Duckworth, Jinhui Ding, D. Harmer, D. Hernandez, Janel O. Johnson, K. Mok, M. Ryten, D. Trabzuni, R. Guerreiro, R. Orrell, J. Neal, A. Murray, J. Pearson, I. Jansen, David Sondervan, H. Seelaar, D. Blake, Kate Young, Nicola A. Halliwell, J. Callister, G. Toulson, A. Richardson, A. Gerhard, J. Snowden, D. Mann, D. Neary, M. Nalls, T. Peuralinna, Lilja Jansson, V. Isoviita, Anna-Lotta Kaivorinne, M. Hölttä-Vuori, E. Ikonen, R. Sulkava, M. Benatar, J. Wuu, A. Chiò, G. Restagno, G. Borghero, M. Sabatelli, D. Heckerman, E. Rogaeva, L. Zinman, J. Rothstein, M. Sendtner, C. Drepper, E. Eichler, C. Alkan, Z. Abdullaev, S. Pack, A. Dutra, E. Pak, J. Hardy, A. Singleton, N. Williams, P. Heutink, S. Pickering-Brown, H. Morris, P. Tienari, B. Traynor   +75 more
semanticscholar   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Lack of confirmatory data following Article 12 MRL reviews for dicloran, fenazaquin and tebufenozide. [PDF]

EFSA J
European Food Safety Authority (EFSA).
europepmc   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

A Draft Sequence of the Neandertal Genome

Science, 2010
R. Green, J. Krause, Adrian W. Briggs, T. Maricic, U. Stenzel, Martin Kircher, N. Patterson, Heng Li, W. Zhai, Markus Hsi-Yang Fritz, Nancy F. Hansen, E. Durand, Anna-Sapfo Malaspinas, J. Jensen, Tomàs Marquès-Bonet, C. Alkan, Kay Prüfer, M. Meyer, H. Burbano, J. Good, R. Schultz, Ayinuer Aximu-Petri, Anne Butthof, Barbara Höber, Barbara Höffner, M. Siegemund, A. Weihmann, C. Nusbaum, E. Lander, C. Russ, Nathaniel Novod, J. Affourtit, M. Egholm, C. Verna, P. Rudan, D. Brajković, Ž. Kućan, I. Gusic, V. Doronichev, L. Golovanova, C. Lalueza-Fox, M. de la Rasilla, Javier Fortea, A. Rosas, R. Schmitz, Philip L. F. Johnson, E. Eichler, D. Falush, E. Birney, J. Mullikin, M. Slatkin, R. Nielsen, J. Kelso, M. Lachmann, D. Reich, S. Pääbo   +55 more
semanticscholar   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Thinking Critically About Algorithms for Automated Detection of Behavior: 11 Guidelines for Social and Behavioral Scientists. [PDF]

Dev Sci
de Barbaro K, Madden-Rusnak A, Timmons A.   +2 more
europepmc   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source