Results 21 to 30 of about 811 (136)
Clinical multiplexed exome sequencing distinguishes adult oligodendroglial neoplasms from astrocytic and mixed lineage gliomas [PDF]
, 2014 Classifying adult gliomas remains largely a histologic diagnosis based on morphology; however astrocytic, oligodendroglial and mixed lineage tumors can display overlapping histologic features.Abedalthagafi, Malak, Alexander, Brian M., Beroukhim, Rameen, Bi, Wenya Linda, Brown, Loreal, Cryan, Jane B., Dunn, Ian F., Folkerth, Rebecca D., Haidar, Sam, Hornick, Jason L., Knoff, David S., Ligon, Azra H., Ligon, Keith L., Lindeman, Neal I., Ramkissoon, Lori A., Ramkissoon, Shakti H., Reardon, David A., Santagata, Sandro, Schultz, Nikolaus, Wen, Patrick Y. +19 morecore +1 more sourceMicrovascular Pathology and Morphometrics of Sporadic and Hereditary Small Vessel Diseases of the Brain [PDF]
, 2014 Small vessel diseases (SVDs) of the brain are likely to become increasingly common in tandem with the rise in the aging population. In recent years, neuroimaging and pathological studies have informed on the pathogenesis of sporadic SVD and several ...Adler, Alafuzoff, Arvanitakis, Bailey, Baker, Bell, Brown, Brown, Brown, Brown, Brown, Brulin-Fardoux, Brun, Burke, Carare, Caronti, Chabriat, Colmant, Craggs, Craggs, Cumurciuc, Dalkara, Debette, Deramecourt, Ding, Dubois, Dubois, Dziewulska, Emre, Esiri, Fazekas, Fernando, Ferrer, Foster, Furuta, Furuyama, Gamble, Giwa, Gold, Gould, Gould, Grand, Grinberg, Hachinski, Hagel, Hara, Haritoglou, Hassan, Hawkes, Hirabayashi, Ho, Hoffmann, Huang, Ihara, Janaway, Jellinger, Jen, Jouvent, Jouvent, Kalaria, Kalaria, Kalaria, Kalimo, Kalimo, Kinoshita, Kovari, Kovari, Kuo, Lammie, Lammie, Lanfranconi, Lesnik Oberstein, Liem, Liu, Low, McKeith, Miao, Miao, Miao, Moody, Neuropathology Group, Nichtweiss, O'Sullivan, Okamoto, Okamoto, Okeda, Okeda, Okeda, Ophoff, Pantoni, Patankar, Plaisier, Polvikoski, Roman, Ruchoux, Savva, Schmidt, Schmidt, Sibon, Simpson, Simpson, Smallwood, Soontornniyomkij, Sorbi, Sourander, Suter, Swieten, Tanoi, Terwindt, Vahedi, Vahedi, Van der Flier, Verreault, Viswanathan, Viswanathan, Volonghi, Wardlaw, Wardlaw, Wardlaw, Winkler, Yamamoto, Yamamoto, Yamamoto, Yanagawa, Yao, Yao, Yemisci, Zhang, Zhu +128 morecore +1 more sourceNeurologic phenotype of Schimke immuno-osseous dysplasia and neurodevelopmental expression of SMARCAL1
, 2008 Schimke immuno-osseous dysplasia (OMIM 242900) is an uncommon autosomal-recessive multisystem disease caused by mutations in SMARCAL1 (swi/snf-related, matrix-associated, actin-dependent regulator of chromatin, subfamily a-like 1), a gene encoding a ...Armstrong, D.L., Boerkoel, C.F., Choi, K., Clewing, J.M., Deguchi, K., Elizondo, L.I., Fujita, Y., Hirano, R., Huang, C., Inoue, K., Kanemura, Y., Lou, S., Lucke, T., Marwedel, K.M., Northrop, J., Okano, H., Powell, R., SantaCruz, K., Sloan, E.A., van der Kooy, D., Willaime-Morawek, S. +20 morecore +1 more sourceIdentification of Small Molecule Inhibitors of Tau Aggregation by Targeting Monomeric Tau As a Potential Therapeutic Approach for Tauopathies. [PDF]
, 2015 A potential strategy to alleviate the aggregation of intrinsically disordered proteins (IDPs) is to maintain the native functional state of the protein by small molecule binding.Callaway, Kari, Dobson, Christopher M, Mandelkow, Eckhard, Mandelkow, Eva M, McConlogue, Lisa, Neumann, Thomas, Pickhardt, Marcus, Schenk, Dale, Schwizer, Daniel, St George-Hyslop, Peter, Tóth, Gergely, Vendruscolo, Michele +11 morecore +1 more sourceFully Humanized Bispecific T Cell Engager Shows Potent Activity in Central Nervous System and Peripheral Tumors
Advanced Science, EarlyView.This study reports the development of a fully humanized bispecific T cell engager targeting IL13RA2, a tumor‐associated antigen enriched in glioblastoma. This off‐the‐shelf immunotherapy drives potent, antigen‐dependent T cell activation and tumor killing, and prolongs survival in experimental GBM and other solid tumors models without detectable off ...Joseph T. Duffy, Angela Martin‐Regalado, Benedikt E. Haupt, Jacob R. Pogue, Aditi Thakur, Manuel Fierro Cota, Markella Zannikou, Sol Misener, Vera P. Krymskaya, Kathleen McCortney, Jason Miska, Craig Horbinski, Dmitri Simberg, Maciej S. Lesniak, Charles D. James, Roger Stupp, Irina V. Balyasnikova +16 morewiley +1 more sourceDiabetes Is Associated with Cerebrovascular but not Alzheimer\u27s Disease Neuropathology [PDF]
, 2016 INTRODUCTION: The relationship of diabetes to specific neuropathologic causes of dementia is incompletely understood.
METHODS: We used logistic regression to evaluate the association between diabetes and infarcts, Braak neurofibrillary tangle stage, and ...Abner, Ahtiluoto, Air, Akomolafe, Almdal, Arvanitakis, Arvanitakis, Beeri, Bennett, Bennett, Berg, Bonfim, Braak, Brundel, Chengjie Xiong, Cholerton, Crane, David A. Bennett, David W. Fardo, Erin L. Abner, Erten-Lyons, Folsom, Folstein, Frederick A. Schmitt, Gelber, Green, Heitner, Hiroko H. Dodge, Irie, Janson, Julie A. Schneider, Kamal Masaki, Kaye, Lei Yu, Luchsinger, MacKnight, Mast, Matsuzaki, Mirra, Monte, Montine, Nelson, Nigel J. Cairns, Peila, Peter T. Nelson, Randall L. Woltjer, Rastas, Reiman, Richard J. Kryscio, Rosen, Schmitt, Schneider, Schütt, Sonnen, Starks, Suzanne L. Tyas, Talbot, Thambisetty, Vandal, Willette, Wolf, Yarchoan, Zoe Arvanitakis +62 morecore +2 more sourcesMolecular and clinical features of a Japanese medulloblastoma cohort: Subgroup‐specific prognostic stratification using economical/accessible diagnostic methods
Brain Pathology, EarlyView.This study characterizes the molecular subgroup–specific features of a nationwide Japanese cohort comprising 242 medulloblastomas (MBs). Furthermore, we introduce SEE‐6‐CNA, a simple, cost‐effective, and FFPE‐compatible molecular test that is applicable to routine pathology samples and serves as a surrogate for risk stratification in non‐WNT/non‐SHH ...Kohichi Go, Asako Katsuma, Ema Yoshioka, Tomoko Shofuda, Kohei Fukuoka, Koichi Ichimura, Yuko Matsushita, Yohei Mineharu, Yasuhide Makino, Takeshi Kawauchi, Atsushi Sasaki, Junko Hirato, Takeshi Inoue, Yoshinori Kodama, Masayuki Mano, Daisuke Kanematsu, Noriyuki Kijima, Naoki Kagawa, Dai Keino, Akitake Mukasa, Tomonari Suzuki, Koji Yoshimoto, Daisuke Kuga, Keishi Horiguchi, Shigeru Yamaguchi, Masayuki Kanamori, Kai Yamasaki, Kenichi Ishibashi, Takuya Akai, Masayoshi Yamaoka, Ryuji Ishizaki, Atsufumi Kawamura, Shigeo Ohba, Joji Ishida, Ryo Ando, Junya Fukai, Tomoru Miwa, Masazumi Fujii, Ai Muroi, Kuniaki Saito, Atsuko Harada, Yasuhiko Hayashi, Masahiro Nonaka, Young‐Soo Park, Yusuke Kobayashi, Tadashi Higuchi, Yosuke Miyairi, Kazuhisa Yoshifuji, Noriyoshi Takebe, Soichi Oya, Kosuke Nakajo, Mitsutoshi Nakada, Yoshiteru Nakano, Mizuki Kambara, Koji Adachi, Kazuhiro Tanaka, Hideo Nakamura, Yukihiko Sonoda, Ryuta Saito, Takafumi Wataya, Kazuhiko Kurozumi, Michael D. Taylor, Yoshitaka Narita, Soichiro Shibui, Hajime Arai, Hiroaki Sakamoto, Isao Date, Motoo Nagane, Ryo Nishikawa, Yoshiki Arakawa, Yonehiro Kanemura +70 morewiley +1 more sourceA Nationwide Central Diagnosis for Pediatric CNS Tumors in Japan: The JCCG Brain Tumor and Pathology Committees
Cancer Science, EarlyView.In this report, we present the results of a nationwide initiative launched by the Japan Children's Cancer Group to provide integrated diagnoses for pediatric central nervous system (CNS) tumors, incorporating central pathological review and molecular profiling.Yoshiko Nakano, Junko Hirato, Takako Yoshioka, Tetsuya Takimoto, Sumihito Nobusawa, Kaishi Satomi, Ran Tomomasa, Seiji Yamada, Taku Homma, Shoh Sasaki, Ayako Yamazaki, Maki Sakaguchi, Yasuhide Takeuchi, Nei Fukazawa, Kai Yamasaki, Kohei Fukuoka, Yui Shinohara Kimura, Yuki Nagayama, Yohei Inoue, Akira Miyahira, Ema Yoshioka, Asako Katsuma, Hayato Fukusumi, Tomoko Shofuda, Yuko Hibiya, Yuko Matsushita, Mai Honda Kitahara, Yuki Yomoda, Miho Kato, Michael D. Taylor, Yasuhito Arai, Tatsuhiro Shibata, Hiroaki Sakamoto, Keita Terashima, Yoshiki Arakawa, Toshihiro Kumabe, Ryo Nishikawa, Junichi Hara, Yonehiro Kanemura, Koichi Ichimura +39 morewiley +1 more sourceIncreased mRNA expression of CDKN2A is a transcriptomic marker of clinically aggressive meningiomas [PDF]
, 2023 Homozygous deletion of CDKN2A/B was recently incorporated into the World Health Organization classification for grade 3 meningiomas. While this marker is overall rare in meningiomas, its relationship to other CDKN2A alterations on a transcriptomic ...Aldape, Kenneth, Barnholtz-Sloan, Jill, Behling, Felix, Boutros, Paul C, Brandner, Sebastian, Bunda, Severa, Cohen-Gadol, Aaron, Dogan, Helin, Gao, Andrew, Hoffman, Elgin, International Consortium on Meningiomas (ICOM), Kaloti, Ramneet, Liu, Jeff, Nassiri, Farshad, Patil, Vikas, Raleigh, David R, Sahm, Felix, Skardelly, Marco, Tabatabai, Ghazaleh, Tatagiba, Marcos, Wang, Justin Z, Yakubov, Rebecca, Yefet, Leeor S, Zadeh, Gelareh +23 morecore
