Results 31 to 40 of about 212,774 (309)

Description of a new species of the genus Eperopeus Mills, 1967 (Crustacea, Amphipoda, Pardaliscidae) from the Clarion-Clipperton Zone, Central Pacific Ocean [PDF]

ZooKeys
A new species of the previously monotypic genus Eperopeus within the family Pardaliscidae is described from the Clarion-Clipperton Zone in the Pacific Ocean. An updated diagnosis of Eperopeus and a key to distinguish the two species is provided.
Tammy Horton, Georgina Valls Domedel, Eva C. D. Stewart, Ed A. Hendrycks   +3 more
doaj   +3 more sources

The Naomi Cook Book: A Narrative of Canadian Jewish Integration

Canadian Jewish Studies, 2020
Canadian Jewish integration was a social process that took place in the political sphere, but was also driven by everyday practices such as preparing and consuming food.
Gesa Trojan
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Revision of the world species of Piogaster Perkins (Hymenoptera, Ichneumonidae, Pimplinae), ectoparasitoids of jumping spiders (Araneae, Salticidae) with a description of one new species [PDF]

Journal of Hymenoptera Research
The world species of Piogaster Perkins are revised including the description of a new species: Piogaster variegata Bass, Bennett & Schwarzfeld, sp. nov. from Alberta, Canada. The new species is described and the seven previously known species are
Amber Bass, Andrew M. R. Bennett, Tamara Spasojevic, Marla Schwarzfeld   +3 more
doaj   +3 more sources

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

A revision of the parasitoid wasp genus Dolichogenidea Viereck (Hymenoptera, Braconidae) in the Neotropical region, with the description of 102 new species [PDF]

ZooKeys
The parasitoid wasp genus Dolichogenidea is currently the second most speciose within the subfamily Microgastrinae (Hymenoptera: Braconidae), with 366 world species known so far, but with hundreds awaiting to be described.
Jose L. Fernandez-Triana, Caroline Boudreault, James B. Whitfield, Amelie Höcherl, M. Alex Smith, Winnifred Hallwachs, Daniel H. Janzen   +6 more
doaj   +3 more sources

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Activist Unbelief in Canadian History

Secularism and Nonreligion, 2018
Canada has a long history of religious unbelief. This paper offers a social historical survey of its organized, activist forms. The radical thought of the Enlightenment was imported in the late eighteenth century, which saw Voltairean deists like Fleury ...
Elliot Hanowski
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source