Results 201 to 210 of about 4,028,214 (240)

Effect of maintaining apical patency with a CM instrument on apical transportation and centering ability. [PDF]

Braz Oral Res
Santos CCD, Díaz Zamalloa SI, Gavini G, Chilvarquer I, Caldeira CL.   +4 more
europepmc   +1 more source

ViTAMIn‐O: Democratizing Computer Vision‐Based Machine Learning for Stem Cell Research

Advanced Intelligent Systems, EarlyView.
This study introduces a fully open generalist computer vision model for predicting the differentiation outcomes of stem cell‐based model systems, together with its code‐free deployment platform, ColabViTAMIn‐O. It is benchmarked against various architectures, datasets, and training protocols.
Ferhat Hamurcu, Markus Breunig, Arpad Varga, Bianka Bosch, Jessica Lindenmayer, Anjan T. Kanakappady, Kevin Achberger, Natalia Pashkovskaia, Alexander Kleger, Stefan Liebau, Stefanie Klingenstein, Moritz Klingenstein   +11 more
wiley   +1 more source

Deep Learning Classification of Pancreatic Cancer Cells Over a Progression of Epithelial to Mesenchymal States by Deformability Cytometry Under Microfluidic Viscoelastic Flows

Advanced Intelligent Systems, EarlyView.
Cancer cells progressively spread over intermediate epithelial‐to‐mesenchymal transition states that cause nuclear enlargement and circular redistribution of filamentous vimentin are classified by deformability cytometry coupled to a multi‐region deep learning model with convolutional feature extraction and attention‐based regional aggregation.
Javad Jarmoshti, Hanyuan Gao, Negin Zeinali, Abdullah‐Bin Siddique, Sara J. Adair, Todd W. Bauer, Matthew J. Lazzara, Xiaoxuan Yang, Nathan S. Swami   +8 more
wiley   +1 more source

Impact of Downward Load and Rotational Kinematics on Root Canal Instrumentation with a Heat-Treated Nickel-Titanium Rotary Instrument. [PDF]

Materials (Basel)
Yamamoto R, Maki K, Kimura S, Omori S, Hirano K, Ebihara A, Yahata Y, Okiji T.   +7 more
europepmc   +1 more source

AI‐Powered 3D Liver Fat Volumetric Map for Clinical‐Grade Steatosis Assessment From Cross‐Modality MRI

Advanced Intelligent Systems, EarlyView.
An automated, AI‐powered system generates a 3D liver fat volumetric map for precise fat fraction quantification from MRI. By overcoming manual analysis constraints, it provides high‐fidelity spatial characterization of steatosis. This graphical abstract highlights a clinically robust framework that enables efficient, anatomically informed assessment ...
Bincan Deng, Yingyun Gong, Xiao Wang, Xinxi Wang, Dingding Chen, Chen Xuan, Qing Xu, Hongwen Zhou, Yuwen Cui, Manuel Doblare   +9 more
wiley   +1 more source

Evaluation of Centering Ability in Artificially Curved Canals with Three Thermomechanically Treated NiTi Instruments: Blue, Pink and Gold. [PDF]

Iran Endod J
Félix A, Aranguren J, Navarrete N, Pérez AR.   +3 more
europepmc   +1 more source

TTC21B: From Modifier to Causative Gene in Joubert Syndrome

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Biallelic pathogenic variants in TTC21B, encoding the retrograde intraflagellar transport protein IFT139, are a known cause of renal and skeletal ciliopathies. Single heterozygous variants in this gene were found to be enriched in a cohort of patients with various ciliopathy phenotypes, including three individuals with Joubert syndrome (JS), a
Valentina Serpieri, Fulvio D'Abrusco, Anna Pichiecchio, Thouraya Ben Younes, Ichraf Kraoua, Enza Maria Valente   +5 more
wiley   +1 more source

Downsizing Electrophilic MAX‐Derived Helical Zipper Peptides to Covalently Bind and Degrade Oncogenic MYC

Angewandte Chemie, EarlyView.
Oncogenic MYC is a transcription factor that is difficult to inhibit. However, precise positioning of an acrylamide electrophile in MAX to covalently bond to the unique Cys438 in MYC, enabled shortening and optimizing of MAX‐derived, helix‐constrained peptides with high‐affinity and selectivity.
Aline Dantas de Araujo, Lei Luo, Mahan Azad, Miao Yu, Jody M. Mason, Junxian Lim, Timothy A. Hill, David P. Fairlie   +7 more
wiley   +2 more sources

Histological analysis of the spatio‐temporal development of porcine knee cartilage in embryonic and early postnatal stages

Animal Models and Experimental Medicine, EarlyView.
This study dynamically charts the developmental process of the knee joint cartilage from the embryonic stage through to postnatal life, revealing key developmental events including the origin of knee joint development, chondrification, primary ossification, secondary ossification, formation of the cartilage cancal, and formation of the growth plate. It
Yan Nie, Kai Wang, Xuewen Wang, Jinzhu Jing, Zhen Liang, Guoqiang Yan, Wen Feng Guo, Meng Zhang, Wei Zhang, Lei Xiang   +9 more
wiley   +1 more source

A DNA G‐Quadruplex‐Targeting Ligand Suppresses c‐MYC Expression: Implications for Gemcitabine‑Resistant Pancreatic Cancer

Angewandte Chemie, EarlyView.
PQB‐4, a fluorescent small‐molecule ligand that targets c‐MYC DNA G‐quadruplexes (G4s), showed marked synergy with gemcitabine in resistant PANC‐1 cells (CI = 0.027). In vivo, the ligand reduced tumor weight by 44% in a PANC‐1 xenograft model. These results highlight the therapeutic potential of c‐MYC DNA G4‐targeting ligands for treating gemcitabine ...
Bo‐Xin Zheng, Ya‐Kun Wang, Ze‐Xin Chen, Yi‐Wen Meng, Meng‐Ting She, Jia‐Peng Dong, Yingying Zheng, Yao‐Xun Zeng, Wen‐De Zheng, Wei Long, Wing‐Leung Wong   +10 more
wiley   +2 more sources