Results 61 to 70 of about 4,028,214 (240)

Anorectal Dysfunction in Systemic Sclerosis: Clinical Phenotypes and Functional Patterns

Arthritis Care &Research, EarlyView.
Objective The aim of this study was to characterize specific physiologic defects in anorectal dysfunction in systemic sclerosis (SSc) using anorectal manometry (ARM), evaluate associations with gastrointestinal (GI) and extraintestinal clinical phenotypes, and explore potential serologic markers for risk stratification.
Timothy Kaniecki, Alireza Amindarolzarbi, Tsion Abdi, John Clarke, Michael Hughes, Ami A. Shah, Zsuzsanna H. McMahan   +6 more
wiley   +1 more source

Utilizing the Metastability of Spidroins as a Strategy for Improving Mechanical Properties of Biomimetic Spider Silk Fibers

Advanced Functional Materials, EarlyView.
Phase transitions are central for the assembly of recombinant silk proteins into fibers. Soluble protein can transition into condensed states such as condensates and gels. These states are metastable and evolve in a time‐dependent way. Metastability depends on the protein sequence, and this relationship can be used to enhance the mechanical properties ...
Fred‐Eric Sammalisto, Topias Lankinen, Celine Tallroth, Rafael A. Lara, Matilda Backholm, Markus B. Linder   +5 more
wiley   +1 more source

A Nonlinear Organic Low‐Frequency Sound Sensor Based on Electrochemical Coupling in a Solidified Gel Membrane

Advanced Functional Materials, EarlyView.
A novel nonlinear infrasound sensor concept based on a free‐standing ion conductive gel membrane is introduced. Acoustic signals are directly transduced into an electrical signal using an internal application mechanisms (gating). The nonlinearity might be used for neuromorphic in‐sensor computing. ABSTRACT Measuring low‐frequency or infrasound acoustic
Maarten Mittmann, Carsten Habenicht, Andreas Hofacker, Richard Kantelberg, Stefan Jacob, Karl Leo, Hans Kleemann   +6 more
wiley   +1 more source

Macrophage–Fibroblast Crosstalk Governs Tumor Mechanics, as Revealed by Spatiotemporal Force Mapping in 3D Spheroids

Advanced Healthcare Materials, EarlyView.
This study shows crosstalk among tumor cells, fibroblasts, and macrophages alters the physical forces inside 3D tumor spheroids. Incorporating deformable microparticles in 3D tumor spheroids, the researchers mapped mechanical stresses spatially and with respect to tumor growth (temporally).
Kunal P. Pednekar, Daan Vorselen, Jai Prakash   +2 more
wiley   +1 more source

Shaping ability of HyFlex EDM and ProTaper Gold files with or without using glide path files: An in vitro study

Saudi Endodontic Journal
Introduction: The necessity of using a glide path before the canal preparation is inconclusive. Therefore, this study aimed to assess the shaping ability of two rotary systems in the maxillary first molars’ first mesiobuccal canal (MB1), with or without ...
Maryam Gharechahi, Harir Ahmadi, Maryam Forghanirad, Melika Hoseinzadeh, Anahita Nouri   +4 more
doaj   +1 more source

Comparison of shaping ability of ProTaper Next and 2Shape nickel–titanium files in simulated severe curved canals

Giornale Italiano di Endodonzia, 2018
Aim: To evaluate the centering ability of ProTaper Next (PTN) and 2Shape (TS) nickel–titanium (NiTi) instruments in terms of maintaining the original root canal configuration in a simulated tooth with severe curvature.
Simone Staffoli, Taha Özyürek, Avi Hadad, Alex Lvovsky, Michael Solomonov, Hadas Azizi, Joe Ben Itzhak, Maurizo Bossù, Nicola M. Grande, Gianluca Plotino, Antonella Polimeni   +10 more
doaj   +1 more source

Bioprinted Stiffness‑Tunable Pancreatic Microniches to Decode Early Tumor Initiation Mechanisms

Advanced Healthcare Materials, EarlyView.
Stiffness‐tunable GelMA microniches generated by microvalve bioprinting preserve wild‐type acinar identity while revealing a nonlinear, Kras‐dependent response to matrix mechanics. Intermediate stiffness promotes acinar‐to‐ductal metaplasia and proliferation, defining a permissive mechanical window.
Aurelien Mazet, Charles Handschin, Theo Desigaux, Nathalie Dusserre, Marie‐Laure Stachowicz, Shane Fennell, Malou Lea, Silvia Arcucci, Benoît Thibault, Jean‐Christophe Fricain, Julie Guillermet‐Guibert, Hugo Oliveira   +11 more
wiley   +1 more source

A 3D‐Printed Model of Human Lactation

Advanced Healthcare Materials, EarlyView.
Breastfeeding supports infant and maternal health, yet in vitro models that mimic human lactation remain scarce. Here, light‐based 3D printing creates high‐resolution, alveoli‐inspired microwells that guide breast cells into polarized microtissues. The printed scaffolds embed slow‐release prolactin microcrystals to deliver hormonal cues, enabling human
Amelia Hasenauer, Marcy Zenobi‐Wong
wiley   +1 more source

Evaluation of Pressure Distribution against Root Canal Walls of NiTi Rotary Instruments by Finite Element Analysis

Applied Sciences, 2020
The aim of this study was to evaluate the contact pressure distribution of two different nickel-titanium (NiTi) endodontic rotary instruments against the root canal walls and to virtually predict their centering ability during shaping with finite element
Giorgia Carpegna, Mario Alovisi, Davide Salvatore Paolino, Andrea Marchetti, Umberto Gibello, Nicola Scotti, Damiano Pasqualini, Alessandro Scattina, Giorgio Chiandussi, Elio Berutti   +9 more
doaj   +1 more source

A Novel 3D Model Co‐Culturing Breast Cancer Cells in Direct Contact with Patient‐Derived Mature Adipocytes Demonstrates Cell‐Type Specific Alterations in Phenotype and Chemosensitivity

Advanced Healthcare Materials, EarlyView.
A novel 3D GelMA co‐culture model enabled sustained direct contact between patient‐derived mature adipocytes and breast cancer cells, revealing subtype‐specific interactions. MDA‐MB‐231 co‐culture caused adipocyte perilipin‐1 loss and reduced chemotherapy responsiveness, while MCF7 cells showed partial epithelial‐mesenchymal transition; both cell lines
Jessika A. Wise, Margaret J. Currie, Helen R. Morrin, Gretel S. Major, Tim B. F. Woodfield, Khoon S. Lim, Elisabeth Phillips   +6 more
wiley   +1 more source