Results 171 to 180 of about 59,343,436 (261)

Lactate‐H3K18la‐RPL11 Axis Drives Gemcitabine Resistance in Pancreatic Cancer by Integrating Protein Synthesis and DNA Damage Repair

Advanced Science, EarlyView.
A lactate‐H3K18la epigenetic axis upregulates RPL11 to drive gemcitabine resistance in pancreatic cancer. RPL11 orchestrates chemoresistance through a dual, compartmentalized role: enhancing cytoplasmic protein synthesis via EEF1A1 stabilization and promoting nuclear DNA damage repair by co‐activating PARP14, thus ensuring robust cell survival ...
Lijun Zhao, Jianzhong Cao, Wenyue Liu, Xuyun Li, Haolin Zhang, Xiaofang Zhang, Shiyang Shi, Huilong Yin, Junjie Li, Angang Yang, Rui Zhang   +10 more
wiley   +1 more source

Along Canal Street Cleveland Drawing

One black and white photographic print of a pen and ink drawing of Canal Street near the Ohio and Erie Canal in Cleveland in Cuyahoga County, Ohio. Several boats and buildings can be seen lining the canal.
Canal Society of Ohio
core  

CausalCellInfer: Prioritizing Cell‐Type‐Specific Disease Associations From Genetically Predicted Transcriptomes in Biobank Cohorts

Advanced Science, EarlyView.
Bulk and genotype‐imputed transcriptomes obscure the cellular drivers of complex disease. CausalCellInfer resolves them by integrating invariant marker selection, deep learning deconvolution, and regularized matrix completion. Applied to ∼500 000 UK Biobank participants across 29 traits, it uncovers hallmark cell‐type proportion shifts, including ...
Liangying Yin, Yujia Shi, Ruoyu Zhang, Yong Xiang, Jinghong Qiu, Pak‐Chung Sham, Hon‐Cheong So   +6 more
wiley   +1 more source

Canal Boat Wooden Rudder

One black and white negative of a closeup of the wooden rudder of a canal boat, probably the Monticello II recreated canal boat on the Ohio and Erie Canal in Roscoe Village in Coshocton County ...
Canal Society of Ohio
core  

NCLX Inhibition plus Ca2+ Delivery Potentiates Electroporation and Antitumor Immunity in Pancreatic Ductal Adenocarcinoma

Advanced Science, EarlyView.
Electroporation combined with NCLX inhibition and Ca2+ delivery induces mitochondrial Ca2+ overload in PDAC cells, triggering pyroptosis, DAMP release, and antitumor immune activation. Simultaneously, suppression of tumor‐derived SPP1 weakens SPP1–CD44 signaling and remodels macrophages toward an antitumor phenotype, thereby enhancing CD8+ T‐cell ...
Chuanbing Zhao, Long He, Yu Lu, Zanglong Deng, Hongzhen Wei, Yunpeng Zhang, Ming Yang, Tao Yin   +7 more
wiley   +1 more source

Unidentified Canal Lock Remains 4

One black and white photographic slide of an unidentified canal lock on the canal, probably the Ohio and Erie Canal in eastern Ohio. The lock gate is closed and water sits between the lock walls.
Canal Society of Ohio
core  

[From text to scene: legal devices and care trajectories in the adoption of children with disabilities]. [PDF]

Cad Saude Publica
Medeiros LSP, Abreu TF, Lourenção LG, Gomes GC, Bonow CA.   +4 more
europepmc   +1 more source

ZMIZ2–DUX4–LGR5 Signaling Axis Maintains Stemness Properties and Facilitates Docetaxel Resistance in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
This study identifies ZMIZ2 as a therapeutic target for docetaxel‐resistant triple‐negative breast cancer, sustaining cancer stemness‐associated properties and docetaxel resistance. ZMIZ2 upregulation enhances DUX4‐mediated LGR5 activation through the SWI/SNF components BRG1 and BAF57.
Xueting Gan, Shulei Sun, Ran Hu, Yuheng Feng, Xinhao Wu, Fangqi Liu, Xuyong Lin, Xiupeng Zhang, Xuezhu Rong, Qiang Han   +9 more
wiley   +1 more source

Canal in Massillon

One black and white photographic slide of a line of canal boats docked in the Ohio and Erie Canal in Massillon in Stark County, Ohio.
Canal Society of Ohio
core  

Prevalence and factors associated with severe pre-operative pain among patients presenting for non-surgical root canal treatment in the national dental PBRN PREDICT endodontic study. [PDF]

J Dent
Mungia R, Funkhouser E, Law AS, Nixdorf DR, Lindquist K, Caprio DS, Fellows JL, Gilbert GH, National Dental PBRN Collaborative Group (The National Dental PBRN Collaborative Group comprises practitioners, faculty, and staff investigators who contributed to this network activity. A list of these persons is at;http://www.nationaldentalpbrn.org/collaborative-group.php).   +10 more
europepmc   +1 more source