Results 161 to 170 of about 7,241,930 (347)

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

IL‐4/STAT6‐signaling Influences Local Inflammation and Regeneration Processes During Acute Pancreatitis and Promotes Fibrosis by a Direct Activation of Pancreatic Fibroblasts During Chronic Pancreatitis

Advanced Science, EarlyView.
IL‐4/IL‐13/STAT6 signaling plays a crucial for the suppression of pro‐inflammation during acute pancreatitis and supports acinar cell regeneration but has only minor impact on fibrogenesis during chronic form of the disease. IL‐4/IL‐13 induce the expression of certain collagens directly in pancreatic fibroblasts via STAT6 activation, whereas ...
ElSheikh H, Salvers A, Piesker J, Buchholz S, Lange R, Ameling S, Steil L, Hammer E, Homuth G, Völker U, Bröker BM, Weiss FU, Sendler M, Glaubitz J   +13 more
wiley   +1 more source

Challenges in long-oval canal cleaning: effects of instrumentation kinematics and ultrasonic irrigation. [PDF]

Braz Dent J
Busquim SSK, Freire LG, Scardini IL, Santos MD.   +3 more
europepmc   +1 more source

Elevator‐Like Hollow Channels in Porous Scaffolds Accelerate Vascularized Bone Regeneration via NETs‐Fibrin‐Mediated Macrophage Recruitment

Advanced Science, EarlyView.
This study demonstrates that how hollow‐channel scaffolds promote vascularized bone regeneration via an immunomodulatory mechanism. The channel structures facilitate the formation of a neutrophil extracellular traps‐fibrin scaffold that recruits vascular endothelial growth factor A (VEGF‐A)‐secreting M2 macrophages to drive angiogenesis. Combining this
Guifang Wang, Rongpu Liu, Huijing Ma, Shuhan Duan, Guangzheng Yang, LingXi Meng, Yuqin Qiao, Dongqiang Song, Wenjie Zhang   +8 more
wiley   +1 more source

Effect of luting materials and root third on glass fiber posts bonding strength after hydrothermal aging. [PDF]

PLoS One
Pinto STP, de Moura Oliveira CR, Tanomaru-Filho M, Reis JMDSN.   +3 more
europepmc   +1 more source

S3RL: Enhancing Spatial Single‐Cell Transcriptomics With Separable Representation Learning

Advanced Science, EarlyView.
Separable Spatial Representation Learning (S3RL) is introduced to enhance the reconstruction of spatial transcriptomic landscapes by disentangling spatial structure and gene expression semantics. By integrating multimodal inputs with graph‐based representation learning and hyperspherical prototype modeling, S3RL enables high‐fidelity spatial domain ...
Laiyi Fu, Penglei Wang, Gaoyuan Xu, Jitao Lu, Qinke Peng, Danyang Wu, Hequan Sun   +6 more
wiley   +1 more source

Micro-CT Evaluation of Dentin Preservation by ProTaper Gold and VDW.Rotate in Oval Mandibular Incisors. [PDF]

ScientificWorldJournal
de Sousa WV, da Cunha Isaltino M, Velozo C, de Andrade Silva S, de Almeida Souto Montenegro L, Dantas HV, de Sousa FB, Albuquerque D.   +7 more
europepmc   +1 more source

A Comparative Study of Temperature Variations in Incisor Root Surfaces During Root Canal Preparation Using Various Rotary Systems and Irrigation Protocols

Mihai Paven, Adrian-George Marinescu, Osama Abuabboud, Laura-Elena Cîrligeriu, Luminiţa Nica, Vlad Tiberiu Alexa, Ruxandra Sava-Roşianu, Atena Găluşcan, Roxana Oancea   +8 more
openalex   +1 more source

EXAMINATION OF THE PATIENT BY A MIDWIFE (PARAMEDIC), INCLUDING OBTAINING BIOLOGICAL MATERIAL FROM THE SURFACE OF THE CERVIX (EXTERNAL UTERINE PHARYNX) AND FROM THE CERVICAL CANAL FOR CYTOLOGICAL EXAMINATION AS PART OF THE FIRST STAGE OF MEDICAL EXAMINATION

, 2023
О. М. Драпкина, R. N. Shepel, I. I. Almazova, L. Yu. Drozdova, R. R. Abdrakhmanov   +4 more
openalex   +1 more source

Targeting IL27RA Enhances Immunotherapy in Triple‐Negative Breast Cancer by Modulating Tumor Cells and the Tumor Microenvironment

Advanced Science, EarlyView.
IL27RA upregulation drives immune evasion in TNBC by suppressing MHC‐I expression and reprogramming T/NK‐cell states, establishing an immune‐excluded tumor phenotype. Targeting this epithelial‐intrinsic IL27RA–PI3K/AKT axis offers a promising strategy to overcome immunotherapy resistance.
Jiachi Xu, Qian Long, Meirong Zhou, Qitong Chen, Jing Peng, Qingchun Liang, Danhua Zhang, Hui Zhou, Wenjun Yi   +8 more
wiley   +1 more source