Results 111 to 120 of about 3,865,485 (280)
FEBS Open Bio, EarlyView.TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao +10 more
wiley +1 more source
Tra correttezza e intolleranza. Radici, forme e compatibilità costituzionale della “Cancel Culture”
Museum, Materials and DiscussionsThe essay analyses the legal admissibility of Cancel Culture. The analysis, distinguishing the consideration of words and actions, starts from the requests for identity politics and the emphasis on political correctness.
Daniele Donati
doaj +1 more source
In vitro generation of regulatory T cells: A challenging tool for studying immune aging in humans
FEBS Open Bio, EarlyView.In vitro induction of human regulatory T cells using standard protocols generates suppressive, Foxp3‐expressing CD4+ T cells independently of TGF‐β supplementation and donor age. Regulatory T (Treg) cells play a key role in immune tolerance and homeostasis.
Lynn Muller +3 more
wiley +1 more source
Critical Discourse Analysis of Social Justice Campaign “Cancel Culture” in the Arab Social Media
University of Chitral Journal of Linguistics and LiteratureCancel culture refers to public backlash through social media in response to actions or statements made by individuals, groups, or organizations, which are considered offensive, harmful, or contrary to social norms or public sentiments.
Sami Hussein A. Ahmed +2 more
doaj
Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level
Aging and Cancer, EarlyView.This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley +1 more source
How Socioeconomic Status Affects Cancel Culture Propensity
Business: 2nd Place (The Ohio State University Edward F. Hayes Advanced Research Forum)Cancel Culture has become prevalent on social media platforms in recent years, which has caused devastating losses to brands.
Shen, Mingnan
core +1 more source
RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu +21 more
wiley +1 more source
«Non si può più ridere di niente?»: quando lo spirito attacca le donne
BetweenPortiamo ulteriormente avanti la riflessione sulla Cancel Culture, stavolta con un dialogo tra Clotilde Bertoni e Corrado Confalonieri: relativo in particolare a due argomenti, la questione di genere, e i vari aspetti della comicità e dell’umorismo.
Clotilde Bertoni, Corrado Confalonieri
doaj +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective The prognosis of glioblastoma (GBM) remains highly unfavorable, largely due to high tumor heterogeneity and an immunosuppressive microenvironment. However, the functional role of PANoptosis in this context is poorly understood. Methods Patients were stratified via K‐means clustering. A risk score model was constructed using prognosis‐
Langfei Tian +6 more
wiley +1 more source