Results 251 to 260 of about 15,351,209 (418)
Analysis of comprehensive genomic profiling of solid tumors with a novel assay for broad analysis in clinical diagnostics
Molecular Oncology, EarlyView.In molecular cancer diagnostics, comprehensive genomic profiling (CGP) is going to replace the small NGS panels since it provides all clinically relevant somatic variants as well as genomic biomarkers with clinical value. Here, we compared two CGP assays and demonstrate that the choice for diagnostic implementation will depend on the specific ...Guy Froyen, Pieter‐Jan Volders, Ellen Geerdens, Severine Berden, Joni Van der Meulen, Aaron De Cock, Stefanie Vermeire, Jacques Van Huysse, Marie de Barsy, Gabriela Beniuga, Wendy W. J. de Leng, Anne M. L. Jansen, Imke Demers, Zeliha Ozgur, Hendrikus Jan Dubbink, Ernst‐Jan M. Speel, Wilfred F. J. van IJcken, Brigitte Maes +17 morewiley +1 more sourceResponse to neoadjuvant chemotherapy in early breast cancers is associated with epithelial–mesenchymal transition and tumor‐infiltrating lymphocytes
Molecular Oncology, EarlyView.Epithelial–mesenchymal transition (EMT) and tumor‐infiltrating lymphocytes (TILs) are associated with early breast cancer response to neoadjuvant chemotherapy (NAC). This study evaluated EMT and TIL shifts, with immunofluorescence and RNA sequencing, at diagnosis and in residual tumors as potential biomarkers associated with treatment response.Françoise Derouane, Jérôme Ambroise, Cédric van Marcke, Mieke Van Bockstal, Martine Berlière, Christine Galant, Hélène Dano, Médina Lougué, Elena Benidovskaya, Guy Jerusalem, Vincent Bours, Claire Josse, Jérôme Thiry, Aurélie Daumerie, Caroline Bouzin, Cyril Corbet, François P. Duhoux +16 morewiley +1 more sourceGlobal, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-years for 32 Cancer Groups, 1990 to 2015: A Systematic Analysis for the Global Burden of Disease Study
JAMA Oncology, 2017 C. Fitzmaurice, Christine Allen, Ryan Barber, L. Barregard, Z. Bhutta, H. Brenner, D. Dicker, Odgerel Chimed-Orchir, R. Dandona, L. Dandona, T. Fleming, M. Forouzanfar, Jamie Hancock, Roderick J Hay, Rachel Hunter-Merrill, Chantal K Huynh, H. Hosgood, C. Johnson, J. Jonas, J. Khubchandani, G. Kumar, Michael Kutz, Q. Lan, H. Larson, Xiaofeng Liang, Stephen S. Lim, Alan D. Lopez, Michael F. MacIntyre, L. Marczak, N. Marquez, A. Mokdad, Christine Pinho, F. Pourmalek, J. Salomon, J. Sanabria, Logan Sandar, B. Sartorius, S. Schwartz, K. Shackelford, K. Shibuya, J. Stanaway, C. Steiner, Jiandong Sun, Ken Takahashi, S. Vollset, T. Vos, Joseph A Wagner, Haidong Wang, R. Westerman, H. Zeeb, Leo Zoeckler, F. Abd-Allah, M. Ahmed, S. Alabed, N. Alam, S. Aldhahri, Girma Alem, Mulubirhan Assefa Alemayohu, R. Ali, Rajaa Al-Raddadi, Azmeraw T. Amare, Y. Amoako, A. Artaman, H. Asayesh, N. Atnafu, A. Awasthi, H. Saleem, A. Barać, Neeraj Bedi, I. Benseñor, A. Berhane, E. Bernabé, B. Betsu, A. Binagwaho, D. Boneya, Ismael Campos-Nonato, C. Castañeda-Orjuela, F. Catalá-López, P. Chiang, C. Chibueze, Abdulaal Chitheer, J. Choi, B. Cowie, S. Damtew, J. D. das Neves, S. Dey, S. Dharmaratne, P. Dhillon, E. Ding, T. Driscoll, D. Ekwueme, A. Endries, M. Farvid, F. Farzadfar, João Fernandes, F. Fischer, Tsegaye Tewelde G/hiwot, A. Gebru, S. Gopalani, A. Hailu, M. Horino, N. Horita, A. Husseini, I. Huybrechts, M. Inoue, F. Islami, M. Jakovljevic, S. James, Mehdi Javanbakht, S. Jee, A. Kasaeian, Muktar Sano Kedir, Y. Khader, Y. Khang, Daniel H. Kim, J. Leigh, S. Linn, R. Lunevicius, Hassan Magdy Abd El Razek, R. Malekzadeh, D. Malta, W. Marcenes, D. Markos, Y. Melaku, K. G. Meles, W. Mendoza, Desalegn Tadese Mengiste, T. Meretoja, T. Miller, K. Mohammad, A. Mohammadi, S. Mohammed, M. Moradi-Lakeh, G. Nagel, D. Nand, Q. L. Le Nguyen, Sandra Nolte, F. Ogbo, K. Oladimeji, Eyal Oren, Mahesh Pa, Eun‐Kee Park, David M Pereira, D. Plass, M. Qorbani, A. Radfar, Anwar Rafay, Mahfuzar Rahman, S. Rana, K. Søreide, Maheswar Satpathy, M. Sawhney, S. Sepanlou, M. Shaikh, Jun She, I. Shiue, H. Shore, M. Shrime, S. So, S. Soneji, V. Stathopoulou, K. Stroumpoulis, M. Sufiyan, Bryan L. Sykes, R. Tabarés-Seisdedos, Fentaw Tadese, B. Tedla, G. Tessema, J. S. Thakur, B. Tran, K. Ukwaja, B. Uzochukwu, V. Vlassov, E. Weiderpass, Mamo Wubshet Terefe, Henock G. Yebyo, H. H. Yimam, N. Yonemoto, M. Younis, Chuanhua Yu, Z. Zaidi, M. Zaki, Z. M. Zenebe, C. Murray, M. Naghavi +184 moresemanticscholar +1 more sourceMolecular and functional profiling unravels targetable vulnerabilities in colorectal cancer
Molecular Oncology, EarlyView.We used whole exome and RNA‐sequencing to profile divergent genomic and transcriptomic landscapes of microsatellite stable (MSS) and microsatellite instable (MSI) colorectal cancer. Alterations were classified using a computational score for integrative cancer variant annotation and prioritization.Efstathios‐Iason Vlachavas, Konstantinos Voutetakis, Vivian Kosmidou, Spyridon Tsikalakis, Spyridon Roditis, Konstantinos Pateas, Ryangguk Kim, Kymberleigh Pagel, Stephan Wolf, Gregor Warsow, Antonia Dimitrakopoulou‐Strauss, Georgios N. Zografos, Alexander Pintzas, Johannes Betge, Olga Papadodima, Stefan Wiemann +15 morewiley +1 more sourceMultiplex single‐cell profiling of putative cancer stem cell markers ALDH1, SOX9, SOX2, CD44, CD133 and CD15 in endometrial cancer
Molecular Oncology, EarlyView.Cancer stem cells are associated with aggressive disease, but a deep characterization of such markers is lacking in endometrial cancer. This study uses imaging mass cytometry to explore putative cancer stem cell markers in endometrial tumors and corresponding organoid models.Hilde E. Lien, Marta E. Hjelmeland, Hege F. Berg, Rose M. Gold, Kathrine Woie, Lars A. Akslen, Ingfrid S. Haldorsen, Camilla Krakstad +7 morewiley +1 more source
