Results 71 to 80 of about 10,935,890 (352)

Environmental management of business processes

Management : Journal of Contemporary Management Issues, 2000
Since the decision-makers in enterprises will accept the goals of environmental management only if they are motivated enough, comprehensible and useful tools should be generated to support environmentally oriented business decision-making.
Vesna Čančer
doaj  

Novel and unscrutinized immune entities of the zebrafish gut

FEBS Letters, EarlyView.
Understudied cells of the zebrafish immune system include bona fide immune cells and epithelial (‐derived) cells with immune functions. Research focusing on zebrafish cells which demonstrate similarities to mammalian immune cell counterparts may help us understand the pathologies in which they are implicated. Currently available and advanced tools make
Audrey Inge Schytz Andersen‐Civil, Marine Mantel, Julia Soh, Serge Mostowy, Sylvia Brugman, Gilles Claude Vanwalleghem   +5 more
wiley   +1 more source

Complement in Cancer and Cancer Immunotherapy

Archivum Immunologiae et Therapiae Experimentalis, 2011
Recently, there has been an increase of interest in the use of biological or immune-based therapies for patients with malignancies. This has been informed by the deeper understanding of the crosstalk between the host immune system and malignant tumours, as well as the potential advantages of immunotherapy-high specificity and less toxicity compared to ...
Laurence Towner, Martin Kolev, Rossen M. Donev   +2 more
openaire   +5 more sources

Signatures of mutational processes in human cancer

Nature, 2013
All cancers are caused by somatic mutations; however, understanding of the biological processes generating these mutations is limited. The catalogue of somatic mutations from a cancer genome bears the signatures of the mutational processes that have been
Ludmil B. Alexandrov, S. Nik-Zainal, D. Wedge, S. Aparicio, S. Behjati, A. Biankin, G. Bignell, N. Bolli, Å. Borg, A. Børresen-Dale, S. Boyault, B. Burkhardt, A. Butler, C. Caldas, Helen R Davies, C. Desmedt, R. Eils, J. Eyfjörd, J. Foekens, M. Greaves, F. Hosoda, B. Hutter, Tomislav Ilicic, S. Imbeaud, Marcin Imielinsk, N. Jäger, David T. W. Jones, David C. Jones, S. Knappskog, M. Kool, S. Lakhani, C. López-Otín, Sancha Martin, N. Munshi, Hiromi Nakamura, P. Northcott, M. Pajic, E. Papaemmanuil, A. Paradiso, J. Pearson, X. Puente, K. Raine, Manasa Ramakrishna, A. Richardson, J. Richter, P. Rosenstiel, M. Schlesner, T. Schumacher, P. Span, J. Teague, Y. Totoki, A. Tutt, R. Valdés-Mas, Marit M. van Buuren, Laura van ’t Veer, A. Vincent-Salomon, N. Waddell, L. Yates, J. Zucman‐Rossi, P. Futreal, U. McDermott, P. Lichter, M. Meyerson, S. Grimmond, R. Siebert, E. Campo, T. Shibata, S. Pfister, P. Campbell, M. Stratton   +69 more
semanticscholar   +1 more source

From lactation to malignancy: A comparison between healthy and cancerous breast gland at single‐cell resolution reveals new issues for tumorigenesis

FEBS Letters, EarlyView.
Single‐cell RNA sequencing reveals an opposite role of SLPI in basal tumors based on metastatic spread, along with shared activation of specific regulons in cancer cells and mature luminal lactocytes, as well as downregulation of MALAT1 and NEAT1 in the latter.
Pietro Ancona, Carlo M. Bergamini, Carlo Ferrari, Stefano Volinia, Nicoletta Bianchi   +4 more
wiley   +1 more source

Cancer Microenvironment and Cancer Vaccine [PDF]

Cancer Microenvironment, 2012
The cancer microenvironment is constituted of non-transformed host stromal cells such as endothelial cells, fibroblasts, various immune cells, and a complex extra-cellular matrix secreted by both the normal and neoplastic cells embedded in it. The importance of the microenvironment and its potential in cancer therapy is just being established.
Zhen-Yu Ding, Yu-Quan Wei, Xue-Lin Zou
openaire   +3 more sources

Field cancerization in breast cancer

The Journal of Pathology, 2022
AbstractBreast cancer affects one in seven women worldwide during their lifetime. Widespread mammographic screening programs and education campaigns allow for early detection of the disease, often during its asymptomatic phase. Current practice in treatment and recurrence monitoring is based primarily on pathological evaluations but can also encompass ...
Emanuela Gadaleta, Graeme J Thorn, Helen Ross‐Adams, Louise J Jones, Claude Chelala   +4 more
openaire   +3 more sources

Cancer cell death induced by the NAD antimetabolite Vacor discloses the antitumor potential of SARM1

FEBS Letters, EarlyView.
Vacor, a compound converted into the toxic metabolite Vacor adenine dinucleotide (VAD) by the nicotinamide salvage pathway enzymes NAMPT and NMNAT2, exhibits antitumor activity by inducing rapid and complete NAD depletion. We report that Vacor toxicity is limited to cell lines expressing high levels of SARM1, a NAD glycohydrolase.
Giuseppe Ranieri, Andrea Lapucci, Giuseppe Orsomando, Nadia Raffaelli, Alberto Chiarugi, Daniela Buonvicino   +5 more
wiley   +1 more source

Tension in Cancer [PDF]

International Journal of Molecular Sciences, 2016
Integrins represent a large family of cell receptors that mediate adhesion to the extracellular matrix (ECM), thereby modulating a variety of cellular functions that are required for proliferation, migration, malignant conversion and invasiveness. During tumorigenesis the conversion of a tumor cell from sessile, stationary phenotype to an invasive ...
Löffek, Stefanie, Franzke, Claus-Werner, Helfrich, Iris   +2 more
openaire   +6 more sources

Iodoterapia do Carcinoma Diferenciado da Tireóide

Revista Brasileira de Cancerologia, 2002
Protocolo de tratamento com iodo radioativo utilizado pelo INCA, elaborado em 1981, em conjunto com o Hospital dos Servidores do Estado, com algumas atualizações.
Instituto Nacional de Câncer
doaj   +1 more source