Results 141 to 150 of about 3,139,231 (313)
Neoadjuvant short-course radiotherapy followed by camrelizumab and chemotherapy for locally advanced rectal cancer: 3-year survival from a phase 2 study. [PDF]
BMC MedLin Z, Zhang P, Cai M, Li G, Liu T, Cai K, Wang J, Liu J, Liu H, Zhang W, Gao J, Wu C, Wang L, Wang Z, Hou Z, Kou H, Tao K, Zhang T. +17 moreeuropepmc +1 more sourceAdditional file 3 of Interaction of lncRNA MIR100HG with hnRNPA2B1 facilitates m6A-dependent stabilization of TCF7L2 mRNA and colorectal cancer progression
, 2022 Hao Liu, Danxiu Li, Lina Sun, Hongqiang Qin, Ahui Fan, Lingnan Meng, Ramona Graves‐Deal, Sarah E. Glass, Jeffrey L. Franklin, Qi Liu, Jing Wang, Timothy J. Yeatman, Hao Guo, Hong Zong, Shuilin Jin, Zhiyu Chen, Ting Deng, Ying Fang, Cunxi Li, John Karijolich, James G. Patton, X Wang, Yongzhan Nie, Daiming Fan, Robert J. Coffey, Xiaodi Zhao, Yuanyuan Lu +26 moreopenalex +1 more sourceEffective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet +17 morewiley +1 more sourceSubmucosal Saline Injection Followed by Endoscopic Ultrasound versus Endoscopic Ultrasound Only for Distinguishing between T1a and T1b Esophageal Cancer: A Single-Blind, Superiority, Phase 3, Randomized Controlled Trial
, 2018 Jian-Jun Li, Longjun He, Chuanbo Xie, Zixian Wang, Yin Li, Yitai Xiao, Xiaoyan Gao, Hongbo Shan, Linna Luo, Liming Chen, Guangyu Luo, Ping Yang, Shuo-Chun Zeng, Guoliang Xu, Rui‐Hua Xu +14 moreopenalex +1 more sourceExploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair +17 morewiley +1 more sourceP1212: RATIONALLY DESIGNED CHIMERIC PI3K-BET BROMODOMAIN INHIBITORS ELICIT CURATIVE RESPONSES IN MYC-DRIVEN LYMPHOMA
HemaSphere, 2023 Danielle H. Oh, Xiao MA, Jackson He, Conor Kearney, Simon J. Hogg, Andrea Newbold, Peter Fraser, Ian G. Jennings, Daniella Brasacchio, Olivia Susanto, Chun Yew Fong, Mark A. Dawson, Emily Gruber, Lev Kats, Ricky W. Johnstone, Philip E. Thompson, Jake Shortt +16 moredoaj +1 more source